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| 1 | Percutaneous ethanol injection, radiofrequency and their combination in treatment of hepatocellular carcinoma显示文摘AIM: To evaluate the therapeutic effect and the indication of percutaneous ethanol injection (PEI),radiofrequency ablation (RFA) and their combination in treatment of hepatocellular carcinoma (HCC).METHODS: Two hundred and fifty-five patients with HCC received treatment of PEI, RFA or their combination.Group1 (< 3 cm in diameter, n=85) was treated with PEI,group2 (< 3 cm in diameter, n=153) with RFA. Group3(>3 cm in diameter, n=86) was divided into two groups.Group 3a (n=34) was treated with RFA, while group 3b(n=52) was treated with RFA for 2 wk after transcatheter arterial chemoembolization or PEI. Contrast-enhanced sonography was performed for 61 patients before and after RFA. Liver function and serum alpha-fetoprotein (AFP) were measured for all patients. Changes of the lesions on ultrasound and contrast-enhanced CT/MRI were evaluated for assessing the therapeutic responses.The 1-, 2-, 3- and 5-year survival rates were recorded after treatment.RESULTS: In group 1, the complete necrosis rate of lesions after 1 mo was 77.6% (66/85). The level of AFP declined conspicuously after 1 mo. The 1-, 2-, 3- and 5-year survival rate after treatment was 80.0% (52/65),60.4% (32/53), 52.5% (21/40) and 33.3% (7/21),respectively. In group 2, the complete necrosis rate of lesions after 1 moh was 92.2% (141/153). The level of AFP decreased conspicuously after 1 mo. The 1-, 2-,3- and 5-year survival rate after treatment was 94.6%(88/93), 73.2% (52/71), 63.5% (33/52) and 46.4%(13/28), respectively. In group 3a, the complete necrosis rate of lesions after 1 mo was 23.5% (8/34). AFP dropped down to the normal level in only one patient after 1 mo. The 1-, 2- and 3-year survival rate after treatment was 47.6% (10/21), 42.9% (6/14) and 27.3%(3/11), respectively. Only one patient was still alive after 5 years. In group 3b, the complete necrosis rate of lesions after 1 mo was 57.7% (30/52). The level of AFP decreased after 1 mo. The 1-, 2-, 3- and 5-year survival rate after treatment was 68.6% (24/35), 46.2% (12/26),36.8% (7/19) and 27.3% (3/11), respectively.CONCLUSION: The therapeutic effect of RFA on small HCC is better than that of PEI. Small HCC is the optimal indication of RFA. For recurrent HCC (diameter>3 cm),the combined treatment of RFA and PEI/ACE should be used. | Bao-Ming Luo Yan-Ling Wen Hai-Yun Yang Hui Zhi Xiao-Yun Xiao Bing Ou Jing-Sheng Pan Jian-Hong Ma | 2005 | World Journal of Gastroenterology2005，11，40： | 15 |
| 2 | Cerebral and pulmonary embolisms after transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘A cerebral lipiodol embolism is an extremely rare complication of transcatheter arterial chemoem bolization for hepatocellular carcinoma. We present a case of cerebral lipiodol embolism that occurred afte the third arterial chemoembolization, report the clinica and radiological findings, and review the medica literature. | Chang Soo Choi Ki Hoon Kim Geom Seog Seo Eun Young Cho Hyo Jeong Oh Suck Chei Choi Tae Hyeon Kim Haak Cheoul Kim Byung Suk Roh | 2008 | World Journal of Gastroenterology2008，14，30： | 10 |
| 3 | 肝动脉化疗栓塞治疗中碘油用量的现状与研究进展显示文摘肝动脉化疗栓塞治疗已成为不可切除性肝癌的重要治疗方法,而到目前为止,碘化油的应用剂量尚无客观标准,多依靠术者的经验而定。本文分析了常规TACE与超常规剂量TACE的优劣,并对碘油剂量术前量化的可行性展开综述。 | 杨永波 程红岩 | 2012 | 介入放射学杂志2012，21，4： | 9 |
| 4 | 肝细胞癌周围微小病灶的影像诊断与介入治疗显示文摘目的:探讨肝细胞癌病灶周围微小病灶的影像诊断及介入治疗效果。方法:由两名有经验的放射学医生共同回顾性分析80例肝细胞癌病灶周围微小病灶的螺旋CT及血管造影表现,并达成一致意见。所有病例均行经肝动脉化疗栓塞治疗。结果:80例肝癌患者经螺旋CT或/和DSA造影发现病灶周围微小病灶者37例,其中微小病灶只分布于主灶周围1cm范围内者21例。经肝动脉化疗栓塞治疗可栓塞肝细胞癌周围的微小病灶。结论:肝细胞癌病灶周围的微小病灶存在较为广泛,术前准确诊断有利于指导经肝动脉化疗栓塞治疗。 | 戚跃勇 邹利光 王细文 孙清荣 郝萍 刘卫金 周波 | 2006 | 现代肿瘤医学2006，14，12： | 8 |
| 5 | 原发性肝癌经肝动脉化疗栓塞术后16层螺旋CT表现与血清AFP变化相关性分析显示文摘目的探讨原发性肝细胞性肝癌(HCC)介入治疗后16层螺旋CT表现与血清甲胎蛋白(AFP)含量变化的关系。方法对42例HCC患者,均行经导管肝动脉化疗栓塞术(TACE),术后3~4周行上腹部平扫及双期增强扫描,观察碘油沉积范围和肿瘤强化范围,并同时测定患者血清AFP水平并计算治疗前后其下降百分率,使用统计软件分析两者的相关性。结果42例HCC患者TACE术后,肿瘤强化范围0%~100%不等,其中<25%5例,25%~50%15例,>50%22例,与患者血清AFP含量下降百分率呈负相关(r=-0.776,P<0.05)。碘油沉积范围0%~100%不等,其中无碘油沉积4例,<25%12例,25%~50%16例,>50%10例,与血清AFP含量下降百分率呈正相关(r=0.907,P<0.05)。结论HCC患者TACE后16层螺旋CT表现与血清AFP含量下降百分率具相关性,可以作为介入治疗效果的评价指标。 | 邓瑜萍 卢武胜 喻俊林 郭应坤 李媛 杨志刚 | 2008 | 实用放射学杂志2008，24，10： | 5 |
| 6 | 原发性肝癌肝动脉灌注化疗栓塞治疗后碘化油沉积与CT灌注参数的相关性显示文摘目的探讨原发性肝癌(primary hepatic carcinoma,PHC)肝动脉灌注化疗栓塞(transcatheter arterial chenloenlbolization,TACE)后病灶碘化油(lipiodol,LPD)沉积与CT灌注参数的相关性。方法PHC27例,男性23例,女性4例。年龄28~70(50.9±10.9)岁。所有病例均接受TACE治疗,于TACE治疗前1周内进行肝脏CT灌注扫描。将获得的图像信息传到丁作站,采用灌注软件进行图像分析,计算各灌注参数(斜率法),包括肝动脉灌注量(hepatic arterial pedusion,HAP)、肝门静脉灌注量(hepatic portal perfusion,HPP)、总肝灌注量(total liver perfusion,TLP)和肝动脉灌注指数(hepatic arterial perfusion index,HAPI)。1个月后常规CT扫描,了解病灶LPD沉积情况。采用SPSS12.0统计软件对病灶CT灌注参数与LPD沉积的相关性进行Spearman等级相关分析。结果PHC在TACE治疗后其LPD沉积与CT灌注参数HAP和TLP相关(r=0.771,P=0.000;r=0.565,P=0.002),与HPP和HAPI无相关性(r=0.263,P=0.184;r=0.175,P=0.383)。结论CT灌注成像可用于PHC介入治疗病例的选择及预后的评价。 | 杨林 张小明 董国礼 翟昭华 官泳松 周翔平 | 2008 | 第三军医大学学报2008，30，20： | 4 |
| 7 | 化疗栓塞前后用多层螺旋CT评价肝癌血供显示文摘 | 官泳松 胡颖 贺庆 | 2007 | 放射学实践2007，22，8： | 2 |
| 8 | 肝癌HIF-1α表达与多排CT血供分型的相关性研究与临床意义显示文摘目的:研究肝癌多排CT血供分型与缺氧诱导因子-1α(HIF-1α)表达水平的相关性。材料和方法:对34例手术病理证实的肝癌术前行多排螺旋CT双期扫描观察血供分型,免疫组化SP法检测肝癌Edmondson-Steiner分级对应的HIF-1α和VEGF表达水平,将两者进行对比分析。结果:肝动脉供血型中HIF-1α表达强阳性和阳性最高,其次为肝动脉和门静脉双重供血型者。门静脉供血型和少血供型表达水平最低(P<0.001)。随Edmondson-Steiner分级增高,HIF-1α表达增高(P<0.05)。结论:多排CT双期扫描能够反映肝癌血供分型和血管生成,一定程度上推测HIF-1α表达水平和组织学分级,有利于包括抗血管生成治疗肿瘤方案的选择及预后评估。 | 解云川 周翔平 | 2008 | 中国临床医学影像杂志2008，19，5： | 1 |
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