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| 1 | A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice显示文摘The Wnt signaling pathway plays key roles in differentiation and development and alterations in this signaling pathway are causally associated with numerous human diseases.While several laboratories were examining roles for Wnt signaling in skeletal development during the 1990s,interest in the pathway rose exponentially when three key papers were published in 2001-2002.One report found that loss of the Wnt co-receptor,Low-density lipoprotein related protein-5(LRP5),was the underlying genetic cause of the syndrome Osteoporosis pseudoglioma(OPPG).OPPG is characterized by early-onset osteoporosis causing increased susceptibility to debilitating fractures.Shortly thereafter,two groups reported that individuals carrying a specific point mutation in LRP5(G171V)develop high-bone mass.Subsequent to this,the causative mechanisms for these observations heightened the need to understand the mechanisms by which Wnt signaling controlled bone development and homeostasis and encouraged significant investment from biotechnology and pharmaceutical companies to develop methods to activate Wnt signaling to increase bone mass to treat osteoporosis and other bone disease.In this review,we will briefly summarize the cellular mechanisms underlying Wnt signaling and discuss the observations related to OPPG and the high-bone mass disorders that heightened the appreciation of the role of Wnt signaling in normal bone development and homeostasis.We will then present a comprehensive overview of the core components of the pathway with an emphasis on the phenotypes associated with mice carrying genetically engineered mutations in these genes and clinical observations that further link alterations in the pathway to changes in human bone. | Kevin A.Maupin Casey J.Droscha Bart O.Williams | 2013 | Bone Research2013，1，1： | 18 |
| 2 | DEP结构域的结构与功能显示文摘DEP结构域首次在Dishevelled、EGL-10和Pleckstrin三种蛋白质中发现,是一个高度保守的蛋白结构域。过去20年的研究表明,DEP结构域存在于许多信号蛋白中,并参与了信号转导、细胞极性确立和小分子信号激活等生命活动过程,特别是在GPCR信号转导和Wnt信号通路中起着至关重要的作用。本文将结合最新研究进展,以及通过生物信息学的数据挖掘,对DEP结构域的结构和功能进行简要概述。 | 王心睿 杨红 廖之君 | 2015 | 生命的化学2015，35，2： | 4 |
| 3 | Wnt信号膜质转导的机制显示文摘Wnt信号通路是一条高度保守的信号转导通路,在生物体多个发育过程以及一系列疾病发生中发挥重要作用。Wnt信号通路重要的生物学功能和复杂的信号转导调控网络引起了人们广泛和持续的研究兴趣。介绍了经典Wnt信号通路信号转导的分子框架,结合自身实验室新的研究发现,重点阐述Wnt信号由细胞膜上向细胞质内转导的机制。 | 贾莹莹 李林 | 2015 | 生命科学2015，27，7： | 0 |
| 4 | 癌蛋白DEPDC1B的研究进展显示文摘含有DEP结构域的蛋白质1B(DEPDC1B)高表达于多种恶性肿瘤组织及细胞,其作为癌蛋白参与了多种癌症的发生发展进程,调控了不同的恶性生物学行为,包括促进肿瘤细胞的侵袭、迁移和增殖以及抑制细胞凋亡等,这与其含有的DEP、Rho GAP等结构域的功能密切相关。本文主要结合癌蛋白DEPDC1B的结构域组成,探讨其与癌症发生发展及治疗的关系,旨在为深入研究DEPDC1B在癌症中的作用机制及潜在的抗癌疗法提供参考依据。 | 李则明 黄国锦 王晴晴 | 2023 | 医学新知2023，33，5： | 0 |
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