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| 1 | Transcription Factors Ets2 and Sp1 Act Synergistically with Histone Acetyltrans-ferase p300 in Activating Human Interleukin-12 p40 Promoter显示文摘对研究控制 interleukin (IL ) 的合成的规章的机制有可观的兴趣在 T-helper-1 房间的区别起一个中央作用的 -12, 。在这研究,我们执行了设计阐明的一系列短暂 transfection 实验在 IL-12 倡导者特定的抄写因素(Ets2 和 Sp1 ) 之间的功能的关系并且嘘在 IL-12 规定的一 acetylation 修正由 p300 调停了并且各种各样嘘一 deacetylases (HDAC ) 。在这份报告介绍的结果证明抄写因素 Ets2 和 Sp1 与 p300 synergistically 行动了激活人的 IL-12 倡导者。hist p300 的一项 acetyltransferase (帽子) 活动为这协作效果被要求,因为侵入人体气管粘膜的病菌 E1A 蛋白质禁止了协同作用。相反地, HDAC 镇压了抄写因素的协作效果并且嘘 IL-12 的激活上的一 acetylation,当 p300 能修正它时。这些数据显示了那 Ets2, Sp1 在人的 IL-12 表示的规定与 p300 一致地并且 synergistically 工作了。 | Hai-Jing SUN Xin XU Xiu-Li WANG Liang WEI Fen LI Jun LU Bai-Qu HUANG | 2006 | Acta Biochimica et Biophysica Sinica2006，38，3： | 2 |
| 2 | Structure and functions of transcriptional coactivators p300/CBP and their roles in regulation of interleukin gene expression显示文摘p300/CBP are versatile transcriptional coacti- vators that participate in many physiological processes, in- cluding cell cycle control, differentiation and apoptosis. p300/CBP possess histone acetyltransferase (HAT) activity and they are involved in transcriptional regulation by acety- lating histone and nonhistone proteins. Moreover, they act as protein bridges connecting specific transcription factors to the basal transcription machinery and provide a scaffold to integrate multiple transcription cofactors. Several studies suggest that p300/CBP may serve as tumor suppressors since mutations or translocations in p300/Cbp genes have been observed in a number of cancers. Furthermore, in many neurodegenerative diseases, inhibition of p300/CBP function may be one of the underlying causes of cytotoxicity. Several studies have demonstrated that p300/CBP are implicated in the regulation of many interleukin genes. This review focuses on the structures and functions of p300/CBP and their roles in the regulation of interleukin genes based on the work per- formed in our laboratory. | SHAOYangguang ZHANGGuoping LUJun HUANGBaiqu | 2004 | Chinese Science Bulletin2004，49，24： | 1 |
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