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| 1 | Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia显示文摘BACKGROUND In recent years,increasing evidence of second neoplasms associated with gastrointestinal stromal tumors(GIST)has been found.Numerous case reports,mostly retrospective studies and a few reviews,have been published.To our knowledge,however,no systematic review or meta-analysis of the existing data has been performed so far.AIM To prepare a compilation,as complete as possible,of all reported second tumor entities that have been described in association with GIST and to systematically analyze the published studies with regard to frequency,localization,and types of GIST-associated neoplasms.METHODS The MEDLINE and EBSCO databases were searched for a combination of the keywords GIST/secondary,synchronous,coincident/tumor,neoplasm,and relevant publications were selected by two independent authors.RESULTS Initially,3042 publications were found.After deletion of duplicates,1631 remained,and 130 papers were selected;22 of these were original studies with a minimum of 20 patients,and 108 were case reports.In the 22 selected studies,comprising a total number of 12050 patients,an overall rate of GIST-associated neoplasias of 20%could be calculated.Most second neoplasias were found in the gastrointestinal tract(32%)and in the male and female urogenital tract(30%).The specific risk scores of GISTs associated with other tumors were significantly lower than those without associated neoplasias.CONCLUSION In this first systematic review,we could confirm previously reported findings of a more than coincidental association between GIST and other neoplasias.The question whether there is an underlying causal association will need further investigation.Our data suggest that even GIST with a very low risk of disease progression should prompt screening for second neoplasia and subsequent frequent controls or extended staging. | Johanna Waidhauser Anne Bornemann Martin Trepel Bruno Markl | 2019 | World Journal of Gastroenterology2019，25，30： | 10 |
| 2 | 腹腔镜与开腹胃楔形切除术治疗胃间质瘤患者的临床疗效及安全性对比研究显示文摘目的 分析腹腔镜与开腹胃楔形切除术治疗胃间质瘤(GIST)患者的临床疗效及安全性.方法 抽取2014年3月至2015年64例GSIT患者,根据手术方式不同分为对照和研究组,每组32例.研究组行腹腔镜胃楔形切除术,对照组实施开腹手术,术后1年对两组患者进行随访.对比两组围术期相关指标水平、营养状况相关指标(前白蛋白、转铁蛋白、白蛋白)水平变化情况,并统计两组并发症发生率及疾病复发率.结果 研究组住院时间、切口长度、术中出血量、术后摄食时间、肛门排气时间均明显少于对照组,差异有统计学意义(P〈0.05),两组手术用时比较差异未见统计学意义(P〉0.05);术前两组前白蛋白、转铁蛋白、白蛋白水平比较差异未见统计学意义(P〉0.05),术后研究组前白蛋白[(0.11±0.04)g/L]、转铁蛋白[(0.65±0.29)g/L]明显高于对照组[(0.06±0.03)、(0.48±0.28)g/L],差异有统计学意义(P〈0.05);研究组并发症发生率(12.51%)明显低于对照组(43.76%),差异有统计学意义(P〈0.05);研究组疾病复发率(3.13%)与对照组(6.25%)比较差异未见统计学意义(P〉0.05).结论 采用腹腔镜胃楔形切除术治疗胃间质瘤效果显著,创伤小、手术用时及术后机体功能康复用时较少,可改善术后营养状况,且并发症发生率较低,远期预后较好,值得推广运用. | 邓跃文 | 2017 | 中国实用医刊2017，44，7： | 6 |
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