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| 1 | Characteristics of general distribution of hepatitis B virus genotypes in China显示文摘BACKGROUND:Based on differences in the virus nucleotide sequence,hepatitis B virus(HBV)genotypes are presently divided into genotypes A-H.The geographic distributions of HBV genotypes differ in countries and regions.To determine the general characteristics of their distributions in the mainland of China,we reviewed articles on HBV genotypes published in China. METHODS:The Wanfang Database and the CNKI Database were searched for original articles involving HBV in China,and then the data from the articles were classified according to genotype and latitude and analyzed using SPSS 11.0. RESULTS:The main HBV genotypes were C,B and BC, and their rates were 50.99%,35.58%,6.07%,respectively; other genotypes were rare.There was a negative correlation between latitude and the rate of genotype B (r=-0.782,P<0.01),while a positive correlation existed between latitude and the rate of genotype C(r=0.646, P<0.01).No correlation was observed between latitude and the rates of other genotypes(r=0.294,P>0.05). CONCLUSIONS:In China,HBV genotype C predominates, followed by genotype C and mixed genotype BC;genotypes A,D and others are rare.With an increasing latitude,the distribution of genotype B decreases gradually,while that of genotype C tends to increase.The other genotypes do not show any changes. | Zhu, Chang-Tai Dong, Chun-Lei | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，4： | 32 |
| 2 | Hepatitis C virus genotypes, HLA-DRB alleles and their response to interferon-α and ribavirin in patients with chronic hepatitis C显示文摘BACKGROUND: Hepatitis C virus (HCV) is a worldwide common disease. Some predictive factors influencing the response to interferon alpha (IFN-α) therapy have been identified, but the conclusions differ in various counties and areas. The aim of this study was to study the associa- tions between HCV genotypes, HLA-DRB alleles and their response to IFN-α and ribavirin in Chinese patients with chronic hepatitis C in Northeast China. METHODS: HCV genotypes of 113 patients with HCV were investigated. Gene chips were used to analyze the fre- quency of HLA-DRB in 25 of these patients and their re- sponse to IFN-α and ribavirin. The associations of HCV genotypes, HLA-DRB alleles and their response to IFN-α and ribavirin were also studied. RESULTS: The response rates differed in several types of HCV, with HCV 2b being the highest (57.78% ), HCV 1a and 2a lower (46.15% and 47.62% ) and HCV 1b the low- est (11.76% ). The response rates to IFN-α and ribavirin in patients with DRB1 07 were higher than those with DRB1 04. Sex, HCV type and HLA-DRB were all related to the response. Most female patients with HCV 2b and HLA- DRB1 07 presented complete response, whereas male pa- tients with HCV 1b and HLA-DRB1 04 usually demon- strated no response. DRB1 07 allele and HCV 2b were the factors closely related to the response. CONCLUSIONS: The response rate of HCV 1b may be the lowest even IFN-α and ribavirin are combined in treat- ment. Not only virus but also the host plays an important role in anti-virus therapy. Thus, it is necessary to adjust the host’s immune status to accelerate the clearance of HCV. | Jian Jiao and Jiang-Bin Wang Changchun, China Digestive Department, China-Japan Union Hospital, Jilin University, Changchun 130031 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 2 |
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