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| 1 | CT对土三七致肝窦阻塞综合征的诊断价值显示文摘目的分析土三七致肝窦阻塞综合征的CT表现与特征,探讨CT对该病的诊断价值。方法回顾性分析12例肝窦阻塞综合征的临床及影像资料,患者均有服用中药土三七史。所有病例均行CT平扫及三期增强扫描。结果 CT平扫均发现腹水12例,肝脏肿大及胆囊壁增厚9例。CT动态增强扫描显示肝脏呈斑片状、类地图状强化,可以见到低灌注区。所有病例三支肝静脉主干和下腔静脉肝段均无闭塞。结论腹水、肝脏斑片状强化、肝小静脉的狭窄是肝窦阻塞综合征主要征象。结合患病前服用土三七的病史及CT表现,诊断应考虑肝窦阻塞综合征。 | 牛磊 王明皓 王永康 袁永胜 蔡培 | 2019 | 医学影像学杂志2019，29，4： | 10 |
| 2 | Reliable experimental model of hepatic veno-occlusive disease caused by monocrotaline显示文摘BACKGROUND:Hepatic veno-occlusive disease(HVOD)is a severe complication of chemotherapy before hematopoietic stem cell transplantation and dietary ingestion of pyrrolizidine alkaloids.Many experimental models were established to study its mechanisms or therapy,but few are ideal.This work aimed at evaluating a rat model of HVOD induced by monocrotaline to help advance research into this disease. METHODS:Thirty-two male rats were randomly classified into 5 groups,and PBS or monocrotaline was administered (100 mg/kg or 160 mg/kg).They were sacrificed on day 7(groups A,B and D)or day 10(groups C and E).Blood samples were collected to determine liver enzyme concentrations.The weight of the liver and body and the amount of ascites were measured.Histopathological changes of liver tissue on light microscopy were assessed by a modified Deleve scoring system.The positivity of proliferating cell nuclear antigen(PCNA)was estimated. RESULTS:The rats that were treated with 160 mg/kg monocrotaline presented with severe clinical symptoms (including two deaths)and the histopathological picture of HVOD.On the other hand,the rats that were fed with 100 mg/kg monocrotaline had milder and reversible manifestations.Comparison of the rats sacrificed on day 10 with those sacrificed on day 7 showed that the positivity of PCNA increased,especially that of hepatocytes.CONCLUSIONS:Monocrotaline induces acute,dose- dependent HVOD in rats.The model is potentially reversible with a low dose,but reliable and irreversible with a higher dose.The modified scoring system seems to be more accurate than the traditional one in reflecting the histopathology of HVOD.The enhancement of PCNA positivity may be associated with hepatic tissue undergoing recovery. | | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 1 |
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