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| 1 | 糖皮质激素诱导的高血糖及糖尿病研究进展显示文摘由于强大有效的抗炎和免疫抑制作用,糖皮质激素(glucocorticoids, GCs)广泛应用于临床,是治疗风湿免疫病和血液系统等疾病的主要药物之一。诱导高血糖及糖尿病是糖皮质激素最常见副作用之一。如处理不及时会导致原发病控制不佳,增加感染风险,导致高渗性昏迷、酮症酸中毒,延长住院时间及增加死亡率等。对于需要接受中高剂量GCs治疗或已有糖尿病危险因素的患者,建议进行血糖筛查及更严格的血糖控制。GCs对葡萄糖代谢的影响复杂,机制尚未完全清楚,目前认为主要通过增加胰岛素抵抗、增加肝糖异生和诱导胰岛β细胞功能障碍,导致血糖升高。治疗方式主要包括应用口服药物及胰岛素治疗。本文对GCs诱导的高血糖及糖尿病相关机制及诊治进展进行综述。 | 关艳春 唐旖阳 马骁 方美云 | 2022 | 大连医科大学学报2022，44，2： | 9 |
| 2 | 利拉鲁肽联合胰岛素和二甲双胍治疗1例多发性硬化症的类固醇糖尿病患者显示文摘长期大量使用糖皮质激素治疗各种疾病容易导致继发性类固醇糖尿病。新诊断的糖尿病患者中,使用糖皮质激素的患者发病率是未使用糖皮质激素的2~3倍。长期大量使用糖皮质激素可能导致脂肪向心性堆积,胰岛素抵抗,糖调节异常及脂代谢异常。 | 陈晔 张久丹 王坚 | 2014 | 中华内分泌代谢杂志2014，30，3： | 6 |
| 3 | Sitagliptin counteracts seasonal fluctuation of glycemic control显示文摘AIM:To assess the effect of sitagliptin therapy on seasonal fluctuation of glycemic control in Japanese type 2 diabetic patients.METHODS:Participating patients(age:29-80 years) had been treated with conventional oral antidiabetic agents and/or diet and exercise therapy for over 6 mo.From December 2009,35 patients were additionally prescribed oral sitagliptin starting from 50 mg once daily,while 19 patients taking-glucosidase inhibitors were switched to sitagliptin.Twenty-four patients who refused sitagliptin formed the control group.Changes of mean monthly hemoglobin A 1c(HbA 1c) during the 'winter holiday season' were compared between groups using Student's t-test(2008-2009 vs 2009-2010).Statistical significance was accepted at P < 0.05.Multivariate analysis was performed to assess whether sitagliptin use was associated with deterioration or improvement of glycemic control.RESULTS:Both add-on sitagliptin and switching from-glucosidase inhibitors to sitagliptin prevented the seasonal deterioration of glycemic control and tended to improve HbA 1c.Multivariate analysis revealed that both adding and switching to sitagliptin were negatively correlated with deterioration of glycemic control.In 44 patients who continued sitagliptin therapy for another year,elevation of HbA 1c was suppressed without adverse effects.CONCLUSION:Sitagliptin is a suitable oral agent for preventing deterioration of glycemic control during the winter holiday season. | Tomohiro Matsuhashi Motoaki Sano Keiichi Fukuda Shun Kohsaka Yoshihiko Suzuki | 2012 | World Journal of Diabetes2012，3，6： | 1 |
| 4 | 肠促胰素治疗类固醇糖尿病的进展显示文摘类固醇糖尿病是一种特殊类型糖尿病,其发病机制可能与肠促胰素作用受损有关。基于肠促胰素的治疗能提高类固醇糖尿病患者的肠促胰素效应,可能对其治疗有益。笔者对基于肠促胰素治疗类固醇糖尿病的个案报道及临床研究进行了总结。 | 张妲 杨彩哲 关小宏 | 2016 | 临床药物治疗杂志2016，14，2： | 1 |
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