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| 1 | Does aspirin or non-aspirin non-steroidal anti-inflammatory drug use prevent colorectal cancer in inflammatory bowel disease?显示文摘AIM: To determine whether aspirin or non-aspirin nonsteroidal anti-inflammatory drugs(NA-NSAIDs) prevent colorectal cancer(CRC) in patients with inflammatory bowel disease(IBD).METHODS: We performed a systematic review and meta-analysis. We searched for articles reporting the risk of CRC in patients with IBD related to aspirin or NANSAID use. Pooled odds ratios(OR) and 95%CIs were determined using a random-effects model. Publication bias was assessed using Funnel plots and Egger's test. Heterogeneity was assessed using Cochran's Q and the I2 statistic.RESULTS: Eight studies involving 14917 patients and 3 studies involving 1282 patients provided data on the risk of CRC in patients with IBD taking NA-NSAIDs and aspirin respectively. The pooled OR of developing CRC after exposure to NA-NSAIDs in patients with IBD was 0.80(95%CI: 0.39-1.21) and after exposure to aspirin it was 0.66(95%CI: 0.06-1.39). There was significant heterogeneity(I2 > 50%) between the studies. There was no change in the effect estimates on subgroup a na ly s e s o f t he po pulat io n s t udie d o r w he t he r adjustment or matching was performed.CONCLUSION: There is a lack of high quality evidence on this important clinical topic. From the available evidence NA-NSAID or aspirin use does not appear to be chemopreventative for CRC in patients with IBD. | Nick E Burr Mark A Hull Venkataraman Subramanian | 2016 | World Journal of Gastroenterology2016，22，13： | 6 |
| 2 | 炎症性肠病相关性大肠癌显示文摘炎症性肠病(Inflammatory bowel disease,IBD)包括克罗恩病(Crohn,sdisease,CD)和溃疡性结肠炎(ulcerative colitis),目前病因未明,起病慢,病程长,临床表现多样,治愈困难,且被公认与大肠癌关系密切。对IBD患者的直结肠镜监测,有利于及早发现癌性病变并及时救治。本文就IBD相关性大肠癌(IBD—as—sociated colorectal cancer IBD—CRC)的危险因素、分子病理学研究进展、内镜监测及预防作一综述。 | 黄梅芳 程利 | 2012 | 医学新知2012，22，2： | 0 |
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