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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Determining Lyapunov exponents from a time series 显示文摘 | Wolf A J Swift B Swinney H L | 1985 | Physica D1985，16，3： | 2 |
| 4 | Determining Lyapunov Exponents from a Time Series显示文摘 | Wolf A Swift J B Swinney H L | 1985 | Physica1985，16，： | 2 |
| 5 | 艾滋病血清学诊断新方法——免疫斑点法的建立显示文摘运用基因重组技术在大肠杆菌生产出有诊断意义的人免疫缺损病毒(HIV)蛋白,将其初步提纯,再用快速蛋白液相层析技术进一步纯化,即可直接点样至硝酸纤维膜,用来检测HIV抗体。实验显示,这种免疫斑点法(Immunodot assay,IDA)的敏感性与间接免疫荧光法(IIF)相同,而特异性比它高,与蛋白印迹法(WB)相近。由于IDA试剂成本比IIF低,可用于HIV抗体检测的初筛。与IIF相比,IDA法具有假阳性率低、试剂稳定性高、操作简便和不需要昂贵的荧光显微镜等优点。因而是一种适合在基层应用的方法。 | 邵一鸣 曾毅 韩孟杰 Wolf H | 1990 | 病毒学报1990，6，3： | 2 |
| 6 | Quantitative structure-activity relationships and mixture-toxicity studies of alcohols and chlorohydrocarbons: reproducibility of effects on growth and reproduction of Daphnia magna 显示文摘 | Wolf De W Canton J H Deneer J W | 1988 | Aquatic Toxicology1988，12，1： | 1 |
| 7 | 显示文摘 | Marcus J A M | 1994 | J Organomet Chem1994，482，： | 1 |
| 8 | Series resistance effects on solar cell measurements显示文摘 | Wolf M Rauschenbacht H | 1962 | Advanced Energy Conversion1962，3，： | 1 |
| 9 | Determining Lyapunov exponents from a time series显示文摘 | Wolf A Swift J Swinney H | 1985 | Physical D1985，16，3： | 1 |
| 10 | Early expression of angiogenesis factor in acute myocardial ischemia and infarction显示文摘 | Lee S H Wolf P L Escudero R | 2000 | N Engl J Med2000，342，9： | 1 |
| 11 | Heat shock protein70 inhibits apoptosis by preven - ring recruitment of procaspase - 9 to the Apf - 1 apoptosome显示文摘 | Becre H M Wolf B B Green D R | 2000 | Nat Cell Biol2000，2，： | 1 |
| 12 | Time-space Multiscale Analysis by Use of Tensor Product Wavelets and Its Application to Hydrology and GRACE Data 显示文摘 | Nutz H Wolf K | 2008 | Studia Geophysica et Geodaetica2008，52，3： | 1 |
| 13 | The antigenic index: a novel algo- rithm for predicting antigenic determinants显示文摘 | Jameson B A Wolf H | 1988 | Cornput Ap- plBiosci1988，4，1： | 1 |
| 14 | Wave scattering by a canyon of arbitrary shape in a layered half space显示文摘 | Vogt R F Wolf J P Bachmann H | 1988 | Earthquake Engineering and Structural Dynamics1988，16，： | 1 |
| 15 | Rates of nucleotide substitution vary greatly among plant mitochondrial,chloroplast and nuclear DNAs显示文摘 | WOLFE K H LI W H SHARP P M | 1987 | Proc Natl Acad Sci USA1987，84，5： | 1 |
| 16 | The antigenic index:a novel algorithmfor predicting antigenic determinants显示文摘 | Jameson B A Wolf H | 1988 | Comput Appl Biosci1988，4，1： | 1 |
| 17 | Determining Lyapunov exponents from a time series显示文摘 | Wolf A Swift J Swinney H | 1985 | Physica D1985，16，3： | 1 |
| 18 | Rheumatoid Arthritis: Evaluation of Hypervascular and Fibrous Pannus with Dynamic MR Imaging Enhanced with Gd-DTPA显示文摘 | Konig H Sieper J Wolf KJ | 1990 | Radiology1990，176，2： | 1 |
| 19 | Water and Solutions at Negative Pressure: Raman Spectroscopic Study to - 80 Megapascals显示文摘 | Green J L Durben D J Wolf G H | | Science0，249，4969： | 1 |
| 20 | Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA显示文摘 | Wolf A Shimer G H Meehan T | 1987 | Biochemistry1987，26，20： | 1 |
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