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| 1 | 氧化磷酸化与糖酵解:精子以何种途径获取能量?显示文摘精子为高度特异性的细胞,提供精子重要功能的主要能源一一三磷酸腺苷(ATP)主要通过两种代谢途径形成,即糖酵解和氧化磷酸化(OXPHOS)。ATP除了在精子的头部和鞭毛的主段通过糖酵解的方式产生外,在线粒体主要通过OXPHOS的方式产生。然而,在精子成功受精的过程中主要以何种方式产生ATP具有很大的差异性。与糖酵解相比,线粒体呼吸被认为是一种更有效的ATP合成代谢过程。然而,研究表明ATP从线粒体到精子鞭毛末端的扩散电位不足以支持精子的运动,这表明糖酵解是精子尾部区域主要的获能方式。多项研究表明虽然糖酵解是鞭毛产生ATP的主要方式,但是,精子运动所需要的能量主要还是来自于线粒体的呼吸。有些研究表明当糖酵解受到抑制的时候,精子仍能维持其正常的运动和功能,虽然目前尚未明确这种运动是否能持续足够长的时间,是否能够达到有效受精。本文主要目的是对哺乳动物精子能量的代谢进行综述,分析人类精子在受精的过程中以何种ATP代谢途径作为主要的能量供应方式。 | Stefan S du Plessis Ashok Agarwal Gayatri Mohanty Michelle van der Linde | 2015 | Asian Journal of Andrology2015，17，2： | 19 |
| 2 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 3 | 雏鸡成功运输的关键问题显示文摘家禽的健康和生产力在不同生产环境中会表现出较大的变化。了解可导致这种差异的条件及其影响,有助于协调为获得更佳生产性能的支出。良好的开端必不可少,易受攻击的1日龄雏鸡对这些复杂条件的反应会有所不同。繁殖包括遗传和育种;种蛋包括重量、贮存时间和胚胎所处发育状态,因此每一个标明的因子是一个组合体。 | 王晶晶(译) 邹建忠(校) 靳文广(制图表) Gerrit van der Linde | 2016 | 国外畜牧学(猪与禽)2016，36，9： | 4 |
| 4 | Green and competitive:ending the stalemate显示文摘 | Poter M E Van der Linde C | 1995 | Harverd Business Review1995，73，5： | 1 |
| 5 | To ward a new conception of the environment-competitiveness relationship显示文摘 | MICHAEL E PORTER CLASSS VAN DER LINDE | 1995 | Journal of Economic Perspectives1995，9，4： | 1 |
| 6 | Toward a New Conception of the Environment Competitiveness Relationship显示文摘 | Porter M.E Van Der Linde | | 0，，04： | 1 |
| 7 | Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis显示文摘 | van der Linde D Konings EE Slager MA | 2011 | J Am Coil Cardiol2011，58，21： | 1 |
| 8 | Birthprevalence of congenital heart disease worldwide: asystematic review and meta-analysis 显示文摘 | van der Linde D Konings EE Slager MA | 2011 | J Am Coll Cardiol2011，58，21： | 1 |
| 9 | Toward A New Conception of Environ- ment Competitiveness Relationship显示文摘 | Porter M E Van Der Linde C | 1995 | Journal Of Economic Perspec- tives1995，，4： | 1 |
| 10 | Toward a new conception of the environment-competitiveness relation ship显示文摘 | Porter M E van der Linde C | 1995 | Journal of Economics Perspectives1995，9，： | 1 |
| 11 | Greenand Competitive:Ending the Stalemate 显示文摘 | Poter M E Van der Lind C | 1995 | Harvard Busines Review1995，75，5： | 1 |
| 12 | Towards a New Conception of the Environment Competitiveness Relationship显示文摘 | PORTER M A VAN DER LINDE C | 1995 | Journal of Economic Perspective1995，9，4： | 1 |
| 13 | Toward a new conception of the en- vironmentk-competitiveness relationship显示文摘 | Porter M E Van der Linde C | 1995 | The Journal of Eco- nomic Perspectives1995，9，4： | 1 |
| 14 | Propagation of shoots and bulb growth of tulip in vitro 显示文摘 | Hulscher M Krijgsheld H T van der Linde P C G | 1992 | Acta Horticuhurae1992，325，： | 1 |
| 15 | Powder coatings technology: new developments at the turn of the century 显示文摘 | MISEV T A VAN DER LINDE R | 1998 | Progress in Organic Coatings1998，，34： | 1 |
| 16 | Genetic and clini- cal analysis of a large Dutch Gilles de la Tourette family 显示文摘 | Verkerk A J Cath DC van der Linde HC | 2006 | Mol Psychiatry2006，11，10： | 1 |
| 17 | Toward a New Conception of the Environment Competitiveness Relationship 显示文摘 | Porter M E Van der Linde C | 1995 | The Journal of Economic Perspectives1995，，： | 1 |
| 18 | Toward a New Conce- ption of the Environment- Competitiveness Relationship 显示文摘 | PORTER M E VAN DER LINDE C | 1995 | Journal of Economic Perspectives1995，9，4： | 1 |
| 19 | Toward a New Conception of the Environment--Competitiveness Relationship显示文摘 | Porter M E Van Der Linde C | 1995 | Journal of Economic Perspectives1995，9，4： | 1 |
| 20 | Bayesian measures of model complexity and fit (with discussion) 显示文摘 | Spiegelhalter D J Best N G Carlin B P and Van der Linde A | 2002 | Journal of the Royal Statistical Society (Series B)2002，64，4： | 1 |
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