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| 1 | The phytoconstituents and the comparative effects of aqueous extract of Irvingia gabonensis seeds and proviron on the biochemical parameters of male guinea pigs显示文摘Objective:To investigate the phytochemical screening and the effects of the aqueous extracts of the seeds of Irvingia gabonensis on the biochemical parameters of male guinea pigs.Methods: The biochemical parameters were assayed using Randox Diagnostic kits,Phenolphthalein method and colorimetric method.The phytochemical screening was carried out using standard procedures.Results:Phytochemical investigations revealed the presence of flavonoids,tannins, carbohydrate,alkaloids,terpenoids,steroids,volatile oils,saponins and cardiac glycosides.The aqueous extract of Irvingia gabonensis seeds(SO - 400 mg/kg) caused a statistically significant(P< 0.05 ANOVA) decrease in the levels of total cholesterol,urea,uric acid,total protein,prostatic, alkaline,and acid phosphatases.The highest reduction effect was obtained with uric acid at 400 mg/kg of Irvingia gabonensis extract while the least effect was observed in total cholesterol. These effects were dose- and time- dependent.Conclusions:This shows that the seeds of Irvingia gabonensis have hepatoprotective,nephroprotective and cardio protective properties.The study therefore,supports the claims on the use of the seeds of this plant by traditional medicine practitioners as a hepatoprotective and nephroprotective agent Although further studies need to be done to isolate,identify and characterize the active principles in the seeds of this plant. | Obianime AW Uche FI | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，2： | 3 |
| 2 | Is onchocerciasis elimination in Africa feasible by 2025:a perspective based on lessons learnt from the African control programmes显示文摘Background:Onchocerciasis is found predominantly in Africa where large scale vector control started in 1974.Registration and donation of ivermectin by Merck&Co in 1987 enabled mass treatment with ivermectin in all endemic countries in Africa and the Americas.Although elimination of onchocerciasis with ivermectin was considered feasible only in the Americas,recently it has been shown possible in Africa too,necessitating fundamental changes in technical and operational approaches and procedures.Main body:The American programme(OEPA)operating in onchocerciasis epidemiological settings similar to the mild end of the complex epidemiology of onchocerciasis in Africa,has succeeded in eliminating onchocerciasis from 4 of its 6 endemic countries.This was achieved through biannual mass treatment with ivermectin of 85%of the eligible population,and monitoring and evaluation using serological tests in children and entomological tests.The first African programme(OCP)had a head start of nearly two decades.It employed vector control and accumulated lots of knowledge on the dynamics of onchocerciasis elimination over a wide range of epidemiological settings in the vast expanse of its core area.OCP made extensive use of modelling and operationalised elimination indicators for entomological evaluation and epidemiological evaluation using skin snip procedures.The successor African programme(APOC)employed mainly ivermectin treatment.Initially its objective was to control onchocerciasis as a public health problem but that objective was later expanded to include the elimination of onchocerciasis where feasible.Building on the experience with onchocerciasis elimination of the OCP,APOC has leveraged OCP’s vast modelling experience and has developed operational procedures and indicators for evaluating progress towards elimination and stopping ivermectin mass treatment of onchocerciasis in the complex African setting.Conclusions:Following the closure of APOC in 2015,implementation of onchocerciasis elimination in Africa appears to overlook all the experience that has been accumulated by the African programmes.It is employing predominantly American processes that were developed in a dissimilar setting from the complex African onchocerciasis setting.This is impeding progress towards decisions to stop intervention in many areas that have reached the elimination point.This article summarizes lessons learned in Africa and their importance for achieving elimination in Africa by 2025. | Yankum Dadzie Uche V.Amazigo Boakye A.Boatin Azodoga Seketeli | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 3 | Phytochemical constituents,analgesic and anti-inflammatory effects of methanol extract of Triumfetta rhomboidea leaves in animal models显示文摘Objective:To investigate the analgesic and anti-inflammatory effects of the methanolic extract of the leaves of Triumfetta rhomboidea on mice and rats respectively.And to screen the phytochemical constituent of the extract. Methods:The analgesic effect was determined by acetic acid-induced writhing test in mice.While the anti-inflammatory activity was determined by egg albumin-induced oedema of the rat paw.Phytochemical screening was done by standard procedures.Results:Triumfetta rhomboidea leaf extract(50 -400 mg/kg) caused a statistically significant inhibition on the egg albumin-induced eodema or inflammation in Wister albino rats with P<0.001(ANOVA).This effect was higher than the observed effect with Piroxicam(0.5 mg/kg) which was used as a standard.The effect was also dose-dependent.Furthermore,Triumfetta rhomboidea extract caused a statistically significant reduction in the number of acetic acid-induced writhing in mice,with P<0.001(ANOVA).These effects were also does-dependent and greater than the analgesic effects by paracetamol which was used as a reference drug.Phytochemical screening revealed the presence of flavonoids,steroids, triterpenoids alkaloids,tannins and saponins in Truimfetta rhomboidea leaf extract.Conclusion:Triumfetta rhomboidea can be recommended for acute inflammatory disorders and diseases associated with pains.This also supports its traditional use as an anti-snake bite and anti-cancer or anti-tumor agent.Further study is on the way to find out the mechanism of its action and also to isolate,identify and characterize the active principle responsible for these effects in this plant. | Uche FI Okunna BU | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，5： | 2 |
| 4 | Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Uche I.Ezeh Paul J.Turek Renee A.Reijo Amander T.Clark | 2005 | Cancer2005，，10： | 2 |
| 5 | Environmental impact of water supply and water use in a Mediterranean water stressed region显示文摘 | Uche J Martínez-Gracia A Círez F | 2014 | Journal of Cleaner Production2014，，4： | 1 |
| 6 | Thermoeconomic optimization of a dual purpose power and desalination plant显示文摘 | Javier Uche Luis Serra Antonio Valero | 2001 | Desalination2001，136，： | 1 |
| 7 | Gene therapy of hepatocarcinoma:a long way from the concept to the therapeutical impact显示文摘 | GEROLAMI R UCH R BRECHOT C | 2003 | Can Gene Ther2003，10，9： | 1 |
| 8 | Simulation and thermoeconomic analysis of different configuration of gas turbine(GT)-based dual-purpose power and desalination plants(DPPDP)and hybrid plants(HP)显示文摘 | Thibaut Rensonnet Javier Uche Luis Serra | 2007 | Energy2007，32，： | 1 |
| 9 | Comparison of heat transfer coefficient correlations for thermal desalination units显示文摘 | Javier Uche Javier Artal Luis Serra | 2002 | Desalination2002，152，： | 1 |
| 10 | The value of a urine protein-to-creatinine ratio assessment in a single voided urine specimen in prediction of 24-hour proteinuria in pregnancy induced hypertension显示文摘 | Skweres T Preis K Ciepuch R | 2006 | Ginekol Pol2006，77，6： | 1 |
| 11 | Morbidity and mortality amongst infants of diabetic mothers admitted into a special care baby unit in Port Harcourt, Nigeria显示文摘 | Peace IO Tamunopriye J Uche CO | 2010 | hall J Pediat2010，36，77： | 1 |
| 12 | Life cycle assessment of MSF,MED and RO desalination technologies显示文摘 | Raluy G Serra L Uche J | 2006 | Energy2006，31，13： | 1 |
| 13 | 经皮冠状动脉介入后阻塞性睡眠呼吸暂停与心血管事件的关系显示文摘目前关于阻塞性睡眠呼吸暂停(obstructive sleepapnea,OSA)对冠状动脉疾病患者的预后意义的大型队列研究数据匮乏。该研究假设OSA可预测行经皮冠状动脉介入治疗(percutaneous coronary intervention.PCI)患者未来主要不良心脏和脑血管事件(major adverse cardiac and cerebrovascularevents,MACCE)。方法:睡眠及支架研究是一项前瞻性、多中心注册研究,纳入2011年12月和2014年4月来自5个国家经PCI治疗成功的患者1748例。 | Lee CH Sethi R Li R Ho HH Hein T Jim MH Loo G Koo CY Gao XF Chandra S Yang XX Furlan SF Ge Z Mundhekar A Zhang WW Ucha CH Kharwar RB Chan PF Chen SL Chan MY Richards A Tan HC Ong TH Roldan G Tai BC Drager LF Zhang JJ 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 1 |
| 14 | Life cycle assessment of MSF,MED and RO desalination technologies 显示文摘 | Raluy G Serra L Uche J | 2006 | Energy2006，31，13： | 1 |
| 15 | Annexin I is an endogenous ligand that mediates apoptotic cell engulfment显示文摘 | ARUR S UCHE U E REZAUL K | 2003 | Developmental Cell2003，4，4： | 1 |
| 16 | Hepatoma cell-specific ganciclovir-mediated toxicity of a lentivirally transduced HSV-TKEGFP fusion protein gone placed under the control of rat alpha-fetoprotein gone regulatory sequences显示文摘 | Uch R Gerolami R Faivre J | | 0，，9： | 1 |
| 17 | Attenuation of Hippocampal llbeta-Hydroxy-steroid Dehydrogenase Type 1 by Chronic Psychosocial Stress in the Tree Shrew显示文摘 | Jamieson PM uchs E lugge G | 1997 | Stress1997，2，2： | 1 |
| 18 | Thermoeconomic optimization of a dualpurpose and desalination plant显示文摘 | Uche J Serra L Valero A | 2001 | Desalination2001，136，： | 1 |
| 19 | Herpes simplex virus thymidine kinase-mediated suicide gene therapy for hepatoeellular carcinoma using HIV-1-derived lentiviral vectors显示文摘 | Gerolami R Uch R Faivre J | 2004 | J Hepatol2004，40，2： | 1 |
| 20 | Herpes simplex virus thymidine kinase-mediated suicide gene therapy for hepatocellular carcinoma using HIV-1-derived lentiviral vectors显示文摘 | Gerolami R Uch R Faivre J | 2004 | J Hepatol2004，40，2： | 1 |
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