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| 1 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 2 | Evaluation of the dynamics environment of an asteroid: applications to 433 eros显示文摘 | Scheeres D J Williams B G Miler J K | 2000 | Journal of Guidance Control and Dynamics2000，23，3： | 2 |
| 3 | Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension显示文摘 | Scheer FA Van Montfrans GA Van Someren E J | 2004 | J Hypertens2004，43，2： | 1 |
| 4 | Control of hovering spacecraft using altimetry 显示文摘 | SAWAI S SCHEERES D J BROSCHART S B | 2002 | Journal of Guidance Control and Dynamics2002，25，4： | 1 |
| 5 | The effects of supplier fairness on vulnerable resellers显示文摘 | KUMAR N SCHEER L K STEENKAMP J E M | 1995 | Journal of Marketing Research1995，32，2： | 1 |
| 6 | Effects of particle shape on particle identification and scatter predictions 显示文摘 | Scheer C A Ivakhnenko V Stover J C | 2001 | Intl Soc Optical Eng2001，4449，： | 1 |
| 7 | Modeling and optimization of short Yb3+ sensitized Er^3+-doped fiber amplifiers显示文摘 | NILSSON J SCHEER P JASKORZYNSKA B | 1994 | IEEE Photonics Technology Leters1994，6，3： | 1 |
| 8 | Boundedness of spacecraft hovering under dead-band control in time- invariant systems 显示文摘 | BROSCHART S B SCHEERES D J | 2007 | Journal of Guidance Control and Dynamics2007，30，2： | 1 |
| 9 | The Debt of Gratitude: Dissociating Gratitude and Indebtedness 显示文摘 | WATKINS P C SCHEER J OVNICEK M | 2006 | Cognition and Emotion2006，20，2： | 1 |
| 10 | Physiological and anatomic evidence for regulation of the heart by suprachiasmatio nu- cleus in rats 显示文摘 | Scheer FA Ter Horst GJ van Der Vliet J | 2001 | Am J Physiol Heart Circ Physiol2001，280，： | 1 |
| 11 | The effects ofsupplier fairness on vulnerable resellers 显示文摘 | KUMAR N SCHEER L K STEENKAMP J B | 1995 | Journal of Market-ing Research1995，32，1： | 1 |
| 12 | Control of Hov- ering Spacecraft Near Small Bodies: Application to Asteroid 25143 Itokawa 显示文摘 | BROSCHART S B SCHEERES D J | 2005 | Journal of Guidance Control and Dynamics2005，28，2： | 1 |
| 13 | Adverse metabolic and cardiovascular consequences of circadian misalignment 显示文摘 | Scheer F A J L Hilton M F Mantzoros C S | 2009 | Proc Natl Acad Sci U S A2009，106，11： | 1 |
| 14 | Control of Hovering Spacecraft Near Small Bodies:Application to Asteroid 25143 Itokawa显示文摘 | Broschart S B Scheeres D J | 2005 | Journal of Guidance Control and Dynamics2005，28，2： | 1 |
| 15 | The impact of particle morphology on the melting characteristics of matrixembedded Pb nanocrystals显示文摘 | Rosner H Scheer P Weissmuller J | 2003 | Philos Mag Lett2003，83，8： | 1 |
| 16 | The impact of particle morphology on the melting characteristics of matrix- embedded Pb nanocrystals显示文摘 | Rosner H Scheer P Weissmuller J | 2003 | Philosophical Magazine Letters2003，83，8： | 1 |
| 17 | The effects of trust and interdependence on relationship commit- ment; a transatlantic study显示文摘 | GEYSKENS I STEENKAMP J B SCHEER L K | 1996 | International Journal of Re- search in Marketing1996，13，4： | 1 |
| 18 | Con- trol of Hovering Spacecraft Using Altimetry 显示文摘 | SAWAI S SCHEERES D J BROSCHART S B | 2002 | Journal of Guidance Control and Dynamics2002，25，4： | 1 |
| 19 | Control of Hovering Spacecraft Using Altimetry显示文摘 | Sawaim S Scheeres D J Brnschart S B | 2002 | Journal of Guidance Control and Dynamics2002，25，4： | 1 |
| 20 | Polypeptide hormones 显示文摘 | Ryan C A Pearce G Scheer J | 2002 | The Plant Cell2002，14，： | 1 |
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