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| 1 | 欧洲肿瘤内科协会对宫颈癌的诊断、治疗和随访所制定的临床实践指南显示文摘2010年底,在意大利米兰召开了欧洲肿瘤年会。会上推出了常见妇科肿瘤的诊治指南。这些指南与国际妇产科联盟(FIGO)、美国国立综合癌症网(NCCN)等的指南有一些差异,但细腻周全,有其特点和重要参考价值。现邀请北京协和医院杨华博士翻译,《国际妇产科学杂志》主编郎景和教授审校,依宫颈癌、子宫内膜癌、卵巢上皮癌、非卵巢上皮癌顺序陆续发表,以飨读者。指南均发表于欧洲肿瘤协会(European Society forMedical Oncology,ESMO)主办的肿瘤年刊 Annals of Oncology,2010,21(Suppl 5)。 | Haie-Meder C Morice P Castiglione M On Behalf of the ESMO Guidelines Working Group 杨华 郎景和 | 2011 | 国际妇产科学杂志2011，38，1： | 21 |
| 2 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 3 | Thrombin activation and liver inflammation in advanced hepatitis C virus infection显示文摘Hepatitis C virus(HCV) infection is associated with increased thrombotic risk. Several mechanisms are involved including direct endothelial damage by the HCV virus, with activation of tissue factor, altered fibrinolysis and increased platelet aggregation and activation. In advanced stages, chronic HCV infection may evolve to liver cirrhosis, a condition in which alterations in the portal microcirculation may also ultimately lead to thrombin activation, platelet aggregation, and clot formation. Therefore in advanced HCV liver disease there is an increased prevalence of thrombotic phenomena in portal vein radicles. Increased thrombin formation may activate hepatic stellate cells and promote liver fibrosis. In addition, ischemic changes derived from vascular occlusion by microthrombi favor the so called parenchymal extinction, a process that promotes collapse of hepatocytes and the formation of gross fibrous tracts. These reasons may explain why advanced HCV infection may evolve more rapidly to end-stage liver disease than other forms of cirrhosis. | Emilio González-Reimers Geraldine Quintero-Platt Candelaria Martín-González Onán Pérez-Hernández Lucía Romero-Acevedo Francisco Santolaria-Fernández | 2016 | World Journal of Gastroenterology2016，22，18： | 5 |
| 4 | Liver steatosis in hepatitis C patients显示文摘There is controversy regarding some aspects of hepatitis C virus(HCV) infection-associated liver steatosis,and their relationship with body fat stores. It has classically been found that HCV,especially genotype 3,exerts direct metabolic effects which lead to liver steatosis. This supports the existence of a so called viral steatosis and a metabolic steatosis,whichwould affect HCV patients who are also obese or diabetics. In fact,several genotypes exert metabolic effects which overlap with some of those observed in the metabolic syndrome. In this review we will analyse the pathogenic pathways involved in the development of steatosis in HCV patients. Several cytokines and adipokines also become activated and are involved in 'pure' steatosic effects,in addition to inflammation. They are probably responsible for the evolution of simple steatosis to steatohepatitis,making it difficult to explain why such alterations only affect a proportion of steatosic patients. | Emilio González-Reimers Geraldine Quintero-Platt Melchor Rodríguez-Gaspar Remedios Alemán-Valls Onán Pérez-Hernández Francisco Santolaria-Fernández | 2015 | World Journal of Hepatology2015，7，10： | 3 |
| 5 | Adipokines,cytokines and body fat stores in hepatitis Cvirus liver steatosis显示文摘AIM: To identify patients with or without liver steatosis and its severity in treatment-na?ve patients affected by hepatitis C virus(HCV) infection.METHODS: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body(by densitometry), hormones [insulin, homeostatic model assessment(HOMA)], adipokines(resistin, adiponectin, leptin), and cytokines(tumor necrosis factor α, interleukin-6).RESULTS: Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunkfat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and resistin.CONCLUSION: Steatosis in HCV infection is common(67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines. | emilio gonzález-reimers javier lópez-prieto geraldine quintero-platt ricardo pelazas-gonzález m remedios alemán-valls onán pérez-hernández m joséde-la-vega-prieto m angeles gómez-rodríguez candelaria martín-gonzález francisco santolaria-fernández | 2016 | World Journal of Hepatology2016，8，1： | 2 |
| 6 | 显示文摘 | Mirror on the Wall: You're Omnidirectional After All | 1998 | Science1998，282，： | 1 |
| 7 | Use of inhaled nitric oxide in preterm infants 显示文摘 | Kumar P Committee on Fetus and Newborn American Academy of Pedia-trics | 2014 | Pediatrics2014，133，1： | 1 |
| 8 | 显示文摘 | Khandelwal AK Nigam VK Vidyarthi AS Ghosh P Evaluation of various ions and compounds on nitrilase produced from Streptomyces sp | 2010 | Artif Cell Blood Sub2010，38，1： | 1 |
| 9 | 显示文摘 | Seth M L Raychaudhuri S P Investigations on the relationship of new brinjal mosaic virus and its vector Aphis gossypii Glov | 1977 | Acta Botanica Indica1977，5，2： | 1 |
| 10 | Hydrothermal Syntheses and Structures of the Terpyridine Vanadates3, ,and 显示文摘 | Harman P J Zubieta J Structural Influences of Oqrganonitrogen Ligands on Vanadium Oxide Solids | 2000 | Inorg Chem2000，39，15： | 1 |
| 11 | Treatment late effects in long-term survivors of pediatric sarcoma显示文摘 | MANSKY P ARAI A STRAI-I'ON P | 2007 | Pediatr Blood Cancer2007，48，2： | 1 |
| 12 | Synthesis and Characterization of Bis(ether an- hydride)s显示文摘 | Hsiao S H Huang Polyimides based on P C | 1997 | Journal of Polymer Research1997，4，7： | 1 |
| 13 | Area operators for edge detection显示文摘 | Aci'on S T Mukherjee D P | 2000 | Pattern Recognition Letters2000，21，8： | 1 |
| 14 | Analysis of the POLDER(Polarization and Directionality of the Earth's Reflectances) Airborne Instrument Observations over Land Surfaces显示文摘 | Deuzé J L Bréon F M Deschamps P Y | 1993 | Remote Sens Environ1993，45，： | 1 |
| 15 | The Great Crash, the oil price shock, and the Unit root Hypothesis 显示文摘 | Pert'on P | 1989 | Econometriea1989，57，6： | 1 |
| 16 | Catalytic epoxidation of α-pinene over bifunctional mesoporous molecular sieves 显示文摘 | On D T Kapoor M P Joshi P N | 1997 | CatalLett1997，44，34： | 1 |
| 17 | Is the increased risk ofpreterm birth following excision for cervical intraepithelialneoplasia restricted to the first birth post treatment- 显示文摘 | Casta觡on A Landy R Brocklehurst P | 2015 | BJOG2015，122，9： | 1 |
| 18 | Polarized Reflectance of Bare Soils and Vegetation:Measurements and Models显示文摘 | Bréon F M Tanré D Lecomte P | 1995 | IEEE Transactions on Geoscience and Remote Sensing1995，33，2： | 1 |
| 19 | Capillary flow in triangular grooves显示文摘 | AYYASWAMY P S CATI'ON I EDWARDS D K | 1974 | J Applied Mechanics1974，41，： | 1 |
| 20 | Guidelines on myocardial revascularization显示文摘 | The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) Wijns W Kolh P Danchin N | 2010 | Eur Heart J2010，31，20： | 1 |
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