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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Patients'priorities for medical care显示文摘 | Fletcher R H O'Malley M S Earp J A | 1983 | Medical Care1983，21，2： | 1 |
| 3 | TCP Vegas: New techniques for congestion detection and avoidance显示文摘 | O'MALLEY S PETERSON L L | 1994 | Computer Communication Review1994，24，4： | 1 |
| 4 | Image-based gating of intravascular ultrasound pullback sequences显示文摘 | O'Malley SM Granada JF Carlier S | 2008 | IEEE Transactions on Information Technology in Biomedicine2008，12，3： | 1 |
| 5 | Using GC-MS/ Combustion/IRMS to determine the^13 C/^12 C ratios of individual hydrocarbons produced from the combustion of biomass materials--application to biomass burning 显示文摘 | O'Malley V P Burke R A Schlotzhauer W S | 1997 | Organic Geochemistry1997，27，78： | 1 |
| 6 | The x-Kernel: A platform for accessing internet resourees 显示文摘 | L L Peterson N C Hutchinson S W O'Malley H C Rao | 1990 | IEEE Computer (S0018-9162)1990，23，5： | 1 |
| 7 | Topoisomerase Ⅱ alpha and responsiveness of breast cancer to adjuvant chemotherapy显示文摘 | O′Malley FP Chia S Tu D | 2009 | J Natl Cancer Inst2009，101，9： | 1 |
| 8 | Research enrichment:evaluation of structured research in the curriculum for dental medicine students as part of the vertical and horizontal integration of biomedical training and discovery显示文摘 | Kingsley K O'Malley S Stewart T | 2008 | BMC Med Educ2008，8，： | 1 |
| 9 | The need to retrieve the dropped stone during laparoscopic cholecystcomy显示文摘 | Johnston S D Malley F K McEntee B B | 1994 | AM J Surg1994，167，： | 1 |
| 10 | TCP Vegas: New techniques for congestion detection and avoidance 显示文摘 | BRAKMO L S O'MALLEY S W PETERSON L | 1994 | IEEE/ACM Transactions on Networking1994，24，4： | 1 |
| 11 | Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression显示文摘 | Gosselin R D Gibney S O′Malley D | 2009 | Neuroscience2009，159，： | 1 |
| 12 | Sudden hearing loss显示文摘 | MATTHEW O' MALLEY DAVID S | 2008 | Otolaryngol Clin North Am2008，41，3： | 1 |
| 13 | MR urography显示文摘 | HUSSAIN S O′MALLEY M JARA H | 1997 | Magn Reson Imaging Clin N Aam1997，5，1： | 1 |
| 14 | The need to retrieve the dropped stone during laparoscopic cholecystecmy 显示文摘 | Johnston S Malley K McEntee G | 1994 | Am J Surg1994，167，6： | 1 |
| 15 | Using GC-MS/Combustion/IR MS to determine the 13C/12C ratios of individual hydrocarbons produced from the combustion of biomass materials-application to biomass burning显示文摘 | O'Malley V P Burke R A Schlotzhauer W S | 1997 | Organic Geochemistry1997，27，78： | 1 |
| 16 | Parabolic and hyperbolic flexure hinges: flexibility, mo- tion precision and stress characterization based on compliance closed-form equations 显示文摘 | LOBONTIU N PAINE J S N MALLEY E O | 2002 | Precis Eng2002，26，： | 1 |
| 17 | Irradiation of human tubule epithelial cells alters the expression of gene products associated with the synthesis and degredation of extracellular matrix显示文摘 | Malley Y Wei S | 2000 | Radiat Biol2000，76，： | 1 |
| 18 | Portal vein gas resulting from ingestion of hydrogen peroxide 显示文摘 | Ghai S O'Malley ME | 2003 | A JR Am J Roentgenol2003，181，11： | 1 |
| 19 | Assessment of bio- markers of protein anabolism in skeletal muscle during the life span of the rat : sarcopenia despite elevated protein synthesis 显示文摘 | Kimball S R O' Malley J P Anthony J C | 2004 | Am J Physiol Endocrinol Metab2004，287，4： | 1 |
| 20 | Secondgeneration tetracycline-regulatable promoter: repositioned tet operator elements optimize transactivator synergy while shorter minimal promoter offers tight basal leakiness 显示文摘 | Agha-Mohammadi S O' Malley M Etemad A | 2004 | J Gene Med2004，6，7： | 1 |
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