|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Mechanisms of action of arsenic trioxide 显示文摘 | Miller WH Jr Schipper HM Lee JS | 2002 | Cancer Res2002，62，14： | 2 |
| 3 | Predictors of incident diabetes, metabolic syndrome in middle- aged adults: a 10 -year follow- up study from Kinmen, Taiwan 显示文摘 | Sheu WH Chuang SY Lee WJ | 2006 | Diabetes Research and Clinical Practice2006，45，1： | 1 |
| 4 | Association between sleep quality and physical fitness in female young adults 显示文摘 | Lee A J Lin WH | 2007 | The Journal Of Sports Medicine And Physical Fitness2007，47，4： | 1 |
| 5 | Exposure to chronic high glu- cose induces beta-cell apoptosis through decreased interaction of glu- cokinase with mitochondria: down regulation of glucokinase in pancreatic beta-cell显示文摘 | Kim WH Lee JW Suh YH | 2005 | Diabetes2005，54，9： | 1 |
| 6 | All-trans retinoic acid in- hibits type 1 diabetes by T regulatory (Treg)-dependent sup- pression of interferon-gamma-producing T-cells without af- fecting Th17 cells显示文摘 | Van YH Lee WH Ortiz S | 2009 | Diabetes2009，58，1： | 1 |
| 7 | Prognosticators determining survival subsequent to distant metastasis from nasopharyngeal carcinoma 显示文摘 | Teo PM Kwan WH Lee WY | 1996 | Cancer1996，77，： | 1 |
| 8 | Role of mitogen-activated protein kinase kinase in Porphyromonas gingivalis- induced myocardial cell hypertrophy and apoptosis 显示文摘 | Lee SD Chang SH Kuo WH | 2006 | Eur J Oral Sci2006，114，： | 1 |
| 9 | Genes involved with folate uptake and distri- bution and their association with colorectal cancer risk显示文摘 | Figueiredo JC Levine AJ Lee WH Lonti DV Poynter JN Campbell PT | 2010 | Cancer Causes Control2010，21，4： | 1 |
| 10 | Risk factors of treatment failure in diabet- ic foot ulcer patients显示文摘 | Lee KM Kim WH Lee JH | 2013 | Arch Plast Surg2013，40，2： | 1 |
| 11 | Preliminary results of a random- ized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group 显示文摘 | Lee AW Lau WH Tung SY | 2005 | J Clin Onco12005，23，28： | 1 |
| 12 | Incidence and risk factors of breast cancer lymphoedema显示文摘 | Park JH Lee WH Chung HS | | 0，，11： | 1 |
| 13 | Cyclooxygenase-2 expression in human thyroid disease显示文摘 | Lee K J Jung YS Kim WH | 2008 | J Endocrinol Invest2008，31，2： | 1 |
| 14 | Relationship between autoantibody clustering and clinical subsets in SLE: clus- ter and ssociation analyses in Hong Kong Chinese 显示文摘 | Li PH Wong WH Lee TL | 2013 | Rheumatology (Oxford)2013，52，2： | 1 |
| 15 | A Korean herbal medicine,Panax notoginseng,prevents liver fibrosis and hepatic microvascular dysfunction in rats显示文摘 | Park WH Lee SK Kim CH | 2005 | Life Sci2005，76，15： | 1 |
| 16 | Interferon -alpha induces the growth inhibition of human T - cell leukaemia line Jurkat through p38alpha and p38beta 显示文摘 | Lee WH Liu FH Lee YL | 2010 | J Biochem2010，147，5： | 1 |
| 17 | Isolation and properties of a blood coagulation factor Ⅹ activator from the venom of king cobra( Ophiophagus hannah )显示文摘 | Lee WH Zhang Y Wang WY | 1995 | Toxicon1995，33，10： | 1 |
| 18 | Cloning and characterization of a blood coagulation factor Ⅸ - binding protein from the venom of Trimeresurus stejnegeri 显示文摘 | Lee WH Zhuang QY Zhang Y | 2003 | Toxicon2003，41，7： | 1 |
| 19 | A novel chemokine,Leukotactin-1,induces chemotaxis,pro-atherogenic cytokines,and tissue factor expression in atherosclerosis显示文摘 | Lee WH Kim SH Jeong EM Choi YH Kim DI Lee B | 2002 | Atherosclerosis2002，161，2： | 1 |
| 20 | Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage显示文摘 | Yun J Lee WH | 2003 | Mol Cell Biol2003，23，20： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员