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| 1 | DOG1是一种敏感和特异性的胃肠道间质瘤的标记物显示文摘 | Espinosa I Lee C H Kim M K 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，3： | 117 |
| 2 | 利用铅同位素比值判断丹参不同产地来源显示文摘建立了用微柱流动注射与电感耦合等离子体质谱联用的铅同位素比值测量方法。利用铅与 5 磺基 8 羟基喹啉的螯合反应在线分离测定丹参样品中的铅同位素比值 ,并利用铅同位素比值的分布进行中药丹参产地来源的研究。实验结果表明 ,相同地区来源的丹参样品其铅同位素比值分布相对集中 ,而不同地区来源的丹参 ,铅的同位素比值则有明显的区别。因此 。 | 黄志勇 杨妙峰 庄峙厦 王小如 Frank S C Lee | 2003 | 分析化学2003，31，9： | 30 |
| 3 | 加速溶剂萃取-高效液相色谱-电喷雾飞行时间质谱联用分析莲子心中生物碱显示文摘建立了加速溶剂萃取-高效液相色谱-电喷雾飞行时间质谱(ASE-HPLC-DAD-ESI-TOF/MS)联用技术分析莲子心中生物碱类化合物的方法。采用ASE法对药材进行提取,萃取温度为100℃,压力为9646kPa,时间为10min。采用HPLC-DAD-ESI-TOF/MS联用技术对其中的化学成分进行了分离鉴定,HPLC采用AgilentEclipseXDB-C18色谱柱;流动相为0.1%三乙胺溶液,用氨水调pH=8.0(A),色谱纯乙腈(B),梯度洗脱;进样量为20μL,流速:1.0mL/min;检测波长:282nm。ESI-TOF/MS采用正离子电离模式,毛细管电压:4500V;喷雾气压:310.05kPa;干燥气(N2)流速:10.0L/min;干燥气温度:350℃,破碎电压:150V。鉴定了其中的6种生物碱分别为:前荷叶碱、莲心季铵碱、莲心碱、异莲心碱、荷叶碱和甲基莲心碱。 | 李文龙 陈军辉 殷月芬 王小如 Frank S C Lee | 2008 | 分析化学2008，36，1： | 24 |
| 4 | 氮化镓功率晶体管三电平驱动技术显示文摘作为第三代半导体材料的典型代表,宽禁带半导体氮化镓(GaN)材料具有许多硅材料所不具备的优异性能,是高频、高压、高温和大功率应用的优良半导体材料,无论在民用或是军事领域都具有广阔的应用前景。随着GaN技术的进步,大直径硅(Si)基GaN外延技术逐步成熟并向商用化方向发展。2010年以来,多家国际著名半导体厂商相继推出GaN功率晶体管器件。与硅半导体功率器件一样,合理的驱动方式也是GaN功率晶体管优越性能得以体现的重要保障。本文将以GaN功率器件在同步整流Buck变换器中的应用为例,提出一种三电平的驱动方式,以充分发挥GaN功率晶体管器件的优越性。实验结果表明,本文提出的三电平驱动方式可以有效提高变换器的效率。 | 任小永 David Reusch 季澍 穆明凯 Fred C Lee | 2013 | 电工技术学报2013，28，5： | 19 |
| 5 | 气相色谱法在中草药及其制剂中痕量有机氯类农药残留分析上的应用进展显示文摘综述了中草药及其制剂中有机氯类农药残留的气相色谱分析技术,包括样品前处理方法,气相色谱分离分析及确证鉴定技术,对近几年来该领域研究进展进行了总结和讨论。 | 徐晓琴 胡广林 王小如 LEE F S C | 2004 | 分析测试学报2004，23，4： | 15 |
| 6 | The American Heart Association’s Get With the Guidelines(GWTG)-Stroke development and impact on stroke care显示文摘The American Heart Association’s Get With the Guidelines(GWTG)-Stroke programme has changed stroke care delivery in the USA since its establishment in 2003.GWTG is a voluntary registry and continuous quality improvement initiative that collects data on patient characteristics,hospital adherence to guidelines and inpatient outcomes.Implementation of the programme saw increased provision of evidence-based care and improved patient outcomes.This review will describe the development of the programme and discuss the impact on stroke outcomes and transformation of stroke care delivery that followed its implementation. | Cora H Ormseth Kevin N Sheth Jeffrey L Saver Gregg C Fonarow Lee H Schwamm | 2017 | Stroke & Vascular Neurology2017，2，2： | 15 |
| 7 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 8 | 开放手术和经皮螺钉2种内固定方式联合外侧腰椎间融合术(LLIF)治疗成人退变性脊柱侧弯的效果比较显示文摘成人退变性脊柱侧弯(adultdegenerativescoliosis,ADS)老年人常见,50岁以上人群发病率约为6%。采用椎间融合术治疗ADS可获得有效椎间融合,同时纠正畸形。 | Attenello J Chang C Lee YP 陈恩良 吴增晖 | 2018 | 中国骨科临床与基础研究杂志2018，10，3： | 14 |
| 9 | 基因表达分析表明p63是骨巨细胞瘤的一种诊断用标记显示文摘 | Lee C H Espinosa I Jensen K C 饶秋(摘译) | 2008 | 临床与实验病理学杂志2008，24，4： | 13 |
| 10 | 推荐以“EBV相关肺癌”术语替代和扩展肺淋巴上皮瘤样癌的组织学谱系显示文摘肺淋巴上皮瘤样癌(LELC)是一种罕见的EBV相关性癌,其组织学特征为癌细胞呈合体细胞样生长,伴显著的淋巴细胞浸润,组织学上与未分化型鼻咽癌难以区分。研究发现LELC亦可显示非经典组织学形态且缺乏显著的淋巴细胞浸润。作者选取61例肺LELC病例进行全面临床病理分析,并使用免疫组化分析软件对浸润淋巴细胞进行自动定量分析,发现肺LELC形态学上存在连续性谱系,呈现从富于淋巴细胞浸润的经典型未分化LELC至极少淋巴细胞浸润的非经典型组织学形态。 | Yeh Y C Kao H L Lee K L | 2019 | 临床与实验病理学杂志2019，35，5： | 12 |
| 11 | Endothelial progenitor cell differentiation using cryopreserved,umbilical cord blood-derived mononuclear cells显示文摘瞄准:调查 umbilicalcord 血(UCB ) 的 endothelial 区别潜力,我们导致了 endothelial 祖先房间(EPC ) 的区别 fromcryopreserved 导出 UCB 的 mononuclear 房间(MNC ).Methods:从 cryopreserved UCB 和 peripheralblood ( PB )的 MNC 在与为由 RT-PCR ,流动 cytometry ,和 immunocytochemistry analysis.The 的 14 d.EPC werecharacterized 的 endothelial 房间生长补充中等的 M199 是有教养的增长 ofdifferentiated EPC 被3-( 4,5-dimethylthiazol-2-yl )学习 -2,5-diphenyl-tetrazolium 溴化物( MTT )试金,并且脉管的 endothelial 生长因素( VEGF )集中用 导出UCB 的 EPC 的 ELISAkit.Characteristics 被测量与 导出PB 的 EPC.Res 的那些相比 numberof 塑造回合的房间泛泛地在 24 h 文化以后被纳入底部,并且 塑造numerousspindle 的房间开始在 d 上从塑造回合的出现了 7 个 .Those 房间 expressedendothelial 标记例如, Flt-l/VEGFR-1 , ecNOS , VE-cadherin , von Willebrand 因素,并且从 PB 和 UCB 的 EPC 的 endothelial 标记的 secretedVEGF.The 模式没证明 VEGF 的增长和分泌物的 strikingdifferences.The 结果也是 similar.Conclusion :与 endothelialcells.Those EPC 的质量在 -196 ° C 存储进房间的 Wesuccessfully 有教养的 UCB 房间能由激活提高 angiogenesis 的邻近的 endothelial cellsand 被用于 angiogenic 治疗学。 | Jun-ho JANG Sun-kyung KIM Jeong-eun CHOI Young-jin KIM Hyun-woo LEE Seok-yun KANG Joon-seong PARK Jin-hyuk CHOI Ho-yeong LIM Hugh C KIM | 2007 | Acta Pharmacologica Sinica2007，28，3： | 11 |
| 12 | Traveling wave effect on the seismic response of a steel arch bridge subjected to near fault ground motions显示文摘In the 1990s, several major earthquakes occurred throughout the world, with a common observation that near fault ground motion (NFGM) characteristics had a distinct impact on causing damage to civil engineering structures that could not be predicted by using far field ground motions. Since then, seismic responses of structures under NFGMs have been extensively examined, with most of the studies focusing on structures with relatively short fundamental periods, where the traveling wave effect does not need to be considered. However, for long span bridges, especially arch bridges, the traveling wave (only time delay considered) effect may be very distinct and is therefore important. In this paper, the results from a case study on the seismic response of a steel arch bridge under selected NFGMs is presented by considering the traveling wave effect with variable apparent velocities. The effects of fling step and long period pulses of NFGMs on the seismic responses of the arch bridge are also discussed. | 徐艳 George C Lee | 2007 | Earthquake Engineering and Engineering Vibration2007，6，3： | 11 |
| 13 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 14 | Endoscopic ultrasound-guided techniques for diagnosing pancreatic mass lesions: Can we do better?显示文摘The diagnostic approach to a possible pancreatic mass lesion relies first upon various non-invasive imaging modalities, including computed tomography, ultrasound, and magnetic resonance imaging techniques. Once a suspect lesion has been identified, tissue acquisition for characterization of the lesion is often paramount in developing an individualized therapeutic approach. Given the high prevalence and mortality associated with pancreatic cancer, an ideal approach to diagnosing pancreatic mass lesions would be safe, highly sensitive, and reproducible across various practice settings. Tools, in addition to radiologic imaging, currently employed in the initial evaluation of a patient with a pancreatic mass lesion include serum tumor markers, endoscopic retrograde cholangiopancreatography, and endoscopic ultrasound-guided fine needle aspiration(EUS-FNA). EUS-FNA has grown to become the gold standard in tissue diagnosis of pancreatic lesions. | Andrew C Storm Linda S Lee | 2016 | World Journal of Gastroenterology2016，22，39： | 10 |
| 15 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 16 | 铁限制条件下东海原甲藻分泌铁载体显示文摘在铁限制条件下,进行东海原甲藻分泌铁载体的动态研究。对藻类在富铁与缺铁条件下生长状况、生长过程中分泌铁载体的情况以及海藻接种量对铁载体分泌的影响进行了连续观测,结果表明:东海原甲藻在缺铁条件下生长状况远不如在富铁条件下;随着藻类的生长,分泌铁载体不断增多,达指数生长期时,其分泌量也达到了最大值,之后藻类的生长和铁载体分泌都呈现下降趋势;高接种量东海原甲藻能分泌较多的铁载体,并在较短时间到达峰值。 | 王颜萍 何鹰 郑晓玲 陈发荣 李瑞香 Lee Frank S C 王小如 | 2005 | 生态学报2005，25，10： | 10 |
| 17 | Molecular targets in the treatment of alcoholic hepatitis显示文摘Alcohol related costs to health and society are high. One of the most serious complications of alcohol misuse to the individual is the development of alcoholic hepatitis (AH), a clinical syndrome of jaundice and progressive inflammatory liver injury in patients with a history of recent heavy alcohol use. It has a poor outcome and few existing successful therapies. The use of glucocorticoids in patients with severe AH is still controversial and there remains a group of patients with glucocorticoid-resistant disease. However, as our understanding of the pathogenesis of the condition improves there are opportunities to develop new targeted therapies with specific actions to control liver inflammation without having a detrimental effect on the immune system as a whole. In this article we review the molecular mechanisms of AH concentrating on the activation of the innate and adaptive immune response. We consider existing treatments including glucocorticoids, anti-tumor necrosis factor therapy and pentoxifylline and their limitations. Using our knowledge of the disease pathogenesis we discuss possible novel therapeutic approaches. New targets include pro-inflammatory cytokines such as interleukin (IL)-17, chemokines and their receptors (for example IL-8, CXCL9 and CXCR3) and augmentation of anti-inflam- matory molecules such as IL-10 and IL-22. And there is also future potential to consider combination therapy to selectively modulate the immune response and gain control of disease. | Ashwin D Dhanda Richard WL Lee Peter L Collins C Anne McCune | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 18 | 开关电容PWM DC-DC电压调节模块显示文摘介绍了一种开关电容PWM DC-DC电压调节模块,该变换器是开关电容变换器和PWM变换器的结合,具有如下优点:①开关管的零电压开关(Zero-Voltage-Switching,ZVS);②运用自耦变压器实现同步整流管(Synchronous Rectifier,SR)的自驱动,减小了驱动损耗和体二极管导通损耗;③变压器漏感对效率的影响小,可以使用常规的分立式变压器,从而降低成本;④变换器是单相的,结构简单,应用灵活。在理论分析的基础上,搭建了一台四相700kHz 1.2V/130AVRM原理样机验证了理论分析的正确性。 | 曹文静 金科 Ming Xu F C Lee | 2012 | 电工技术学报2012，27，10： | 8 |
| 19 | 层状边坡渐进破裂与失稳过程数值模拟探讨显示文摘运用岩石破裂与失稳过程分析RFPA2D系统 ,以含层理弱层边坡的渐进破裂与失稳分析为例 ,通过对边坡渐进破裂与失稳发生孕育机制及其锚固控制规律的数值模拟 ,数值模拟再现了含层理弱层和锚固边坡渐进破坏与失稳的发生、发展过程。模拟结果表明 。 | 芮勇勤 贺春宁 王惠勇 陈宇亮 Yue Z Q Lee C F 唐春安 | 2002 | 长沙交通学院学报2002，18，3： | 7 |
| 20 | Murine lung eosinophil activation and chemokine production in allergic airway inflammation显示文摘Eosinophils play important roles in asthma and lung infections.Murine models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these diseases.However,little is known about tissue eosinophils in homeostasis.In addition,little data on eosinophil chemokine production during allergic airway inflammation are available.In this study,the properties and functions of homeostatic and activated eosinophils were compared.Eosinophils from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell proliferation.However,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine proteins.Eosinophil intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal degranulation.Lung eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c expression.They were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed lungs.Eosinophil production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation. | C Edward Rose Jr Joanne A Lannigan Paul Kim James J Lee Shu Man Fu Sun-sang J Sung | 2010 | Cellular & Molecular Immunology2010，7，5： | 6 |
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