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| 1 | Bile acid interactions with cholangiocytes显示文摘Cholangiocytes 在他们的顶端的膜暴露于胆汁酸的高集中。为胆汁酸的选择 transporter,顶端的钠胆汁酸 Cotransporter (ASBT )( 也叫作 Ibat;基因名字 Slc10a2 ) 在 cholangiocyte 上是局部性的顶端的膜。在 basolateral 膜上,四个运输系统被识别了(t-ASBT,多药抵抗(MDR ) 3,一个未辩别出的阴离子 exchanger 系统和器官的溶质 transporter (Ost ) 异侧 transporter, Ostalpha-Ostbeta。一起,这些单向性地搬运 ers 从管的胆汁的行动胆汁酸到发行量。cholangiocytes 吸收的胆汁酸为重新分泌物经由仙子胆管丛再循环回到 hepatocytes 进胆汁。这再循环在 hepatocytes 和 cholangiocytes 之间的胆汁酸被叫作 cholehepatic 分流小径。最近的研究建议 cholehepatic 分流小径可以由于额外的肝的阻塞在胆汁酸并且到改编的全面肝胆管运输作出贡献到长期的胆汁郁积。ASBT 被腺苷 3' 尖锐地调整, 5'-monophosphate (营地) 依赖者易位到顶端的膜并且由 phosphorylation 依赖的 ubiquitination 和 proteasome 降级。ASBT 被变化长期地响应胆汁的胆汁酸集中和煽动性的 cytokines 在基因表示调整。cholangiocyte ASBT 的另一潜在的功能是允许 cholangiocytes 取样胆汁的胆汁酸以便激活细胞内部的表明小径。在细胞内部的钙,蛋白质激酶 C (PKC ) , phosphoinositide 3-kinase (PI3K ) ,激活 mitogen 的蛋白质(地图) 激酶和细胞外的调整信号的蛋白质激酶(英皇家空军之阶级最低之兵) 的胆汁酸扳机变化细胞内部的信号。胆汁酸显著地改变 cholangiocyte 分泌物,增长和幸存。不同胆汁酸在 cholangiocyte 上有微分效果细胞内部发信号,并且在一些例子,扳机反对在 cholangiocyte 上完成分泌物,增长和幸存。在这些之上基于概念和观察, cholangiocyte 被建议了是为在肝的胆汁酸的原则目标房间。 | Xuefeng Xia Heather Francis Shannon Glaser Gianfranco Alpini Gene LeSage | 2006 | World Journal of Gastroenterology2006，12，22： | 16 |
| 2 | Heterogeneity of the intrahepatic biliary epithelium显示文摘这评论的目的是在 apoptotic,增生的和分泌活动与变化构画出与胆汁的上皮的词法异质和对肝胃肠激素和肽和肝损伤的不同大小的胆汁管的异构的 pathophysiological 回答有关的最近的调查结果。因为胆汁的上皮细胞(cholangiocytes ) 是人的 cholangiopathies 的目标的识别,胆汁的功能的知识很快正在增加,它被胆汁管的增长 / 损坏在尺寸的一个小范围以内描绘。胆汁的上皮的唯一的解剖,形态学,神经分布和血管形成与在胆汁的树的不同区域以内的 cholangiocytes 的功能一致。在活体内模型[例如,胆汁管结扎( BDL ),部分肝切除术,胆汁酸,四氯化碳( CCl4 )或 alpha-naphthylisothiocyanate ( ANIT )喂]并且在活体内试验性的工具[例如,刚孤立小、大的 cholangiocytes 或肝内胆汁管单位( IBDU )和小、大的鼠科的 cholangiocytes 的主要文化]允许我们表明肝内的胆汁的上皮的词法、功能的异质。这些模型表明了微分分泌活动和异构的 apoptotic 和不同的大小的管的增生的回答。类似于限制为特定的大小的管的 cholangiocyte 增长 / 损害的动物模型,在人的肝疾病,胆汁管损坏支配特定的大小的胆汁管。与肝内的胆汁的上皮的功能的异质有关的未来研究可以与 cholangiopathies 为病人揭示新 pathophysiological 治疗。 | Shannon Glaser Heather Francis Sharon DeMorrow Gene LeSage Giammarco Fava Marco Marzioni Julie Venter Gianfranco Alpini | 2006 | World Journal of Gastroenterology2006，12，22： | 5 |
| 3 | Audit pricing and nature of controlling shareholders:Evidence from France显示文摘This study examines whether auditors are employed as a monitoring mechanism to mitigate agency problems arising from different types of controlling shareholders. In a context of concentrated ownership and poor investor protection, controlling shareholders can easily expropriate wealth from minority shareholders and profit from private benefits of control. However, this agency conflict has been rarely studied, as the most commonly assumed agency conflict occurs between managers and shareholders. Using an audit fee model derived from Simunic(1980), we study the impact of the nature of controlling shareholders on audit fees in French listed firms. Our results show:(1) a negative relationship between audit fees and government shareholdings;(2) a positive relationship between audit fees and institutional shareholdings; and(3) no relationship between audit fees and family shareholdings. These results illustrate the mixed effects of the nature of ownership on audit fees. | Chiraz Ben Ali Cdric Lesage | 2013 | China Journal of Accounting Research2013，，1： | 3 |
| 4 | Glutamate receptor subunit expression in primary neuronal and secondary glial cultures 显示文摘 | Janssens N Lesage AS | 2001 | J Neurochem2001，77，6： | 2 |
| 5 | Glutamate receptor subunit expression in primary neuronal and secondary glial cultures显示文摘 | JANSSENS N LESAGE AS | 2001 | J Neurethem2001，77，6： | 1 |
| 6 | Expasyl: protocol for use with fixed prosthesis显示文摘 | Patric Lesage | 2002 | Clinic2002，23，2： | 1 |
| 7 | Time trends in mortality asso- ciated with depression:Findings from the Stirling Count study 显示文摘 | Murphy J M Gilman S E Lesage A | 2010 | Canadian Journal of Psychiatry2010，55，12： | 1 |
| 8 | Using Home Buyers,Re-vealed Preferences to Define the Urban-rural Fringe显示文摘 | LeSage J P Charles J S | 2008 | Joumal of Geographical Systems2008，10，1： | 1 |
| 9 | Spatial growthregressions: Model specification, estimation andinterpretation显示文摘 | LESAGE J P FISCHER M M | 2007 | Spatial Economic Analysis2007，3，3： | 1 |
| 10 | Management of Cancer Pain 显示文摘 | Lesage P | 1999 | Lancet1999，353，： | 1 |
| 11 | Clinical stress as- sessment using a visual analogue scale显示文摘 | Lesage FX Berjot S Deschamps F | 2012 | Occup Med (Lond)2012，62，8： | 1 |
| 12 | Mechanical Behaviour of a Fuel Cell Stack Under Vibrating Conditions Linked to Aircraft Applications Part h Experimental显示文摘 | ROUSS V LESAGE P BI~GOT S | 2008 | International Journal of Hydrogen Energy2008，，33： | 1 |
| 13 | Homonuclear dipolar decoupling in solid-state NMR using continuous phase modulation显示文摘 | Sakellariou D Lesage A Hodgkinson P | 2000 | Chem Phys Lett2000，319，： | 1 |
| 14 | Selection of Pycnoporus cinnabarinus strains for laccase production显示文摘 | Herpoel I Moukha S Lesage - Messen L | 2000 | FEMS Microbol2000，183，： | 1 |
| 15 | Localization of TREK-1,a two-pore-domain K^+ channel in the peripheral vestibular system of mouse and rat显示文摘 | Nicolas MT Lesage F Reyes R | 2004 | Brain Res2004，1017，12： | 1 |
| 16 | What genetics tells us about the causes and mechanisms of Parkinson' s disease显示文摘 | Corti O Lesage S Brice A | 2011 | Physiol Rev2011，91，4： | 1 |
| 17 | Algebraic Determination of the Structure Function of Dynamic Fault Trees 显示文摘 | Merle G Roussel J M Lesage J J | 2011 | Reliability Engineering & System Safety2011，96，2： | 1 |
| 18 | Molecular and functional properties of two- pore-domain potassium channels 显示文摘 | Lesage F Lazdunski M | 2000 | Am J Physiol Renal Physiol2000，279，5： | 1 |
| 19 | Accumulation of metals in the sediment and reed biomass of a combined constructed wetland treating domestic wastewater显示文摘 | Lesage E Rousseau D P L Meers E | 2007 | Water Air and Soil Pollution2007，183，： | 1 |
| 20 | Accumulation of metals in the sediment and reed biomass of a combined constructed wetland treating domestic wastewater显示文摘 | Lesage E Rousseau D P L Meers E | 2007 | Water Air & Soil Pollution2007，183，14： | 1 |
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