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| 1 | Cerebrospinal fluid phosphorylated tau,visinin-like protein-1,and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease显示文摘Background:Visinin-like protein-1(VILIP-1)and chitinase-3-like protein 1(CHI3L1 or YKL-40)in cerebrospinal fluid(CSF)are newly discovered markers indicating neuronal damage and microglial activation,respectively.Phosphorylated tau(p-tau)reflects the neuropathology of Alzheimer’s disease(AD)and is useful as diagnostic markers for AD.However,it is unknown whether these biomarkers have similar or complementary information in AD.Methods:We stratified 121 participants from the Alzheimer’s Disease Neuroimaging Initiative(ADNI)database into cognitively normal(CN),stable mild cognitive impairment(sMCI),progressive MCI(pMCI),and dementia due to AD.Analysis of covariance(ANOVA)and chi-square analyses,Spearman correlation,and logistic regression models were performed to test the demographic,associations between biomarkers,and diagnostic accuracies,respectively.Linear mixed-effects models were used to evaluate the effects of CSF amyloid-β(Aβ)on above biomarkers within diagnostic groups,the combination of diagnostic group and Aβstatus as predictor,and CSF biomarkers as predictors of AD features,including cognition measured by Mini–Mental State Examination(MMSE)and brain structure and white matter hyperintensity(WMH)measured by magnetic resonance imaging(MRI).Results:P-tau,VILIP-1,and YKL-40 were all predictors of AD diagnosis,but combinations of biomarkers did not improve the diagnostic accuracy(AUC 0.924 for p-tau,VILIP-1,and YKL-40)compared to p-tau(AUC 0.922).P-tau and VILIP-1 were highly correlated(r=0.639,p<0.001)and strongly associated with Aβpathology across clinical stages of AD,while YKL-40 was correlated with Aβpathology in CN and AD groups.VILIP-1 was associated with acceleration of cognitive decline,hippocampal atrophy,and expansion of ventricles in longitudinal analyses.YKL-40 was associated with hippocampal atrophy at baseline and follow-up,while p-tau was only associated with worsening WMH at baseline.Conclusions:CSF levels of p-tau,VILIP-1,and YKL-40 may have utility for discriminating between cognitively normal subjects and patients with AD.Increased levels of both VILIP-1 and YKL-40 may be associated with disease degeneration.These CSF biomarkers should be considered for future assessment in the characterization of the natural history of AD. | Hua Zhang Kok Pin Ng Joseph Therriault Min Su Kang Tharick APascoal Pedro Rosa-Neto Serge Gauthier the Alzheimer’s Disease Neuroimaging Initiative | 2018 | Translational Neurodegeneration2018，7，1： | 5 |
| 2 | MR影像体素形态学的阿尔茨海默病自动分类方法显示文摘为了确定轻度认知功能障碍(MCI)与阿尔茨海默病(AD)患者发生萎缩的重要脑区,实现正常老年人(NC)对照组、MCI与AD三组人群的分类,选择了178名被试的脑部MR影像,利用体素形态学与方差分析方法,考察NC,MCI与AD三组人群的MR影像中灰质体积差异;然后,采用递归特征消去法对特征进行降维;最后,利用线性支持向量机对这3种人群进行分类.实验结果表明,MCI组与NC组、MCI组与AD组、AD组与NC组的平均分类准确率分别为(90.2±1.3)%,(74.7±0.9)%,100%.对分类产生重要影响的脑区包括海马、海马旁回、杏仁核、梭状回和嗅皮层等.所提方法不仅能有效揭示NC,MCI,AD三组人群的脑灰质差异,阐明MCI患者与AD患者脑区发生萎缩的过程与特性,而且能准确区分这3组人群,具有显著的临床应用价值. | 郭圣文 池敏越 岑桂英 匡翠立 牛传筱 赖春任 吴效明 The Alzheimer's Disease Neuroimaging Initiative (ADNI) | 2015 | 东南大学学报(自然科学版)2015，45，2： | 4 |
| 3 | Alzheimer's disease progression model based on integrated biomarkers and clinical measures显示文摘 | Yue QIU Liang LI Tian-yan ZHOU Wei LU Alzheimer's Disease Neuroimaging Initiative | 2014 | Acta Pharmacologica Sinica2014，35，9： | 2 |
| 4 | 阿尔茨海默病的血液生物标志物:一项基于中国多中心的横断面和纵向研究显示文摘阿尔茨海默病(AD)的生物标志物在血液中含量可能因种族、老年性疾病与各种环境风险因素等不同而存在差异,尚缺乏系统性的研究来评估AD生物标志物在中国老年及AD患者人群中的变化以及是否具有准确预测脑内淀粉样蛋白沉积的能力.本工作为一项多中心纵向队列研究,共纳入来自全国各地6个不同临床中心的817个血液样本.研究测量了多个国际上通用的AD生物标志物,包括β-淀粉样蛋白40与42、磷酸化Tau(pTau)蛋白、总Tau蛋白、神经纤维丝轻链(NFL)和胶质纤维酸性蛋白(GFAP),并使用淀粉样斑块PET示踪剂和核磁结构影像对受试者进行综合评估.研究发现,APOE基因型与血浆pTau或血清GFAP组合的预测模型对脑内淀粉样斑块的沉积状态具有较好的区分能力.此外,研究还发现GFAP基线水平越高的患者其神经退行性变的速度越快.本研究结果基于多中心数据,论证了AD血液生物标志物在中国汉族人群中的实用性和应用前景,提示了血液pTau和GFAP是检测AD早期症状的有效指标,为我国AD的早期诊断和治疗提供了参考. | 高峰 戴林斌 王琼 刘畅 邓克学 程昭昭 吕心怡 吴燕 张子伊 陶青青 袁晶 李世平 王越 苏娅 程忻 倪俊 吴志英 张舒婷 施炯 申勇 China Aging and Neurodegenerative Initiative(CANDI)Consortium | 2023 | Science Bulletin2023，68，16： | 2 |
| 5 | Support for research towards understanding the population health vulnerabilities to vector-borne diseases:increasing resilience under climate change conditions in Africa显示文摘Background:Diseases transmitted to humans by vectors account for 17%of all infectious diseases and remain significant public health problems.Through the years,great strides have been taken towards combatting vectorborne diseases(VBDs),most notably through large scale and coordinated control programmes,which have contributed to the decline of the global mortality attributed to VBDs.However,with environmental changes,including climate change,the impact on VBDs is anticipated to be significant,in terms of VBD-related hazards,vulnerabilities and exposure.While there is growing awareness on the vulnerability of the African continent to VBDs in the context of climate change,there is still a paucity of research being undertaken in this area,and impeding the formulation of evidence-based health policy change.Main body:One way in which the gap in knowledge and evidence can be filled is for donor institutions to support research in this area.The collaboration between the WHO Special Programme for Research and Training in Tropical Diseases(TDR)and the International Centre for Research and Development(IDRC)builds on more than 10 years of partnership in research capacity-building in the field of tropical diseases.From this partnership was born yet another research initiative on VBDs and the impact of climate change in the Sahel and sub-Saharan Africa.This paper lists the projects supported under this research initiative and provides a brief on some of the policy and good practice recommendations emerging from the ongoing implementation of the research projects.Conclusion:Data generated from the research initiative are expected to be uptaken by stakeholders(including communities,policy makers,public health practitioners and other relevant partners)to contribute to a better understanding of the impacts of social,environmental and climate change on VBDs(i.e.the nature of the hazard,vulnerabilities,exposure),and improve the ability of African countries to adapt to and reduce the effects of these changes in ways that benefit their most vulnerable populations. | Bernadette Ramirez on behalf of the TDR-IDRC Research Initiative on Vector Borne Diseases and Climate Change | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 6 | Aberrant functional connectivity network in subjective memory complaint individuals relates to pathological biomarkers显示文摘Background:Individuals with subjective memory complaints(SMC)feature a higher risk of cognitive decline and clinical progression of Alzheimer’s disease(AD).However,the pathological mechanism underlying SMC remains unclear.We aimed to assess the intrinsic connectivity network and its relationship with AD-related pathologies in SMC individuals.Methods:We included 44 SMC individuals and 40 normal controls who underwent both resting-state functional MRI and positron emission tomography(PET).Based on graph theory approaches,we detected local and global functional connectivity across the whole brain by using degree centrality(DC)and eigenvector centrality(EC)respectively.Additionally,we analyzed amyloid deposition and tauopathy via florbetapir-PET imaging and cerebrospinal fluid(CSF)data.The voxel-wise two-sample T-test analysis was used to examine between-group differences in the intrinsic functional network and cerebral amyloid deposition.Then,we correlated these network metrics with pathological results.Results:The SMC individuals showed higher DC in the bilateral hippocampus(HP)and left fusiform gyrus and lower DC in the inferior parietal region than controls.Across all subjects,the DC of the bilateral HP and left fusiform gyrus was positively associated with total tau and phosphorylated tau181.However,no significant between-group difference existed in EC and cerebral amyloid deposition.Conclusion:We found impaired local,but not global,intrinsic connectivity networks in SMC individuals.Given the relationships between DC value and tau level,we hypothesized that functional changes in SMC individuals might relate to pathological biomarkers. | Kaicheng Li Xiao Luo Qingze Zeng Yeerfan Jiaerken Xiaojun Xu Peiyu Huang Zhujing Shen Jingjing Xu Chao Wang Jiong Zhou Min-Ming Zhang the Alzheimer’s Disease Neuroimaging Initiative | 2018 | Translational Neurodegeneration2018，7，1： | 2 |
| 7 | Risk and benefits of estrogen plus progestin in healthy postmenopausal women principal results form the women' s health initiative randomized cotrolled trial显示文摘 | | 2002 | JAMA2002，288，3： | 1 |
| 8 | Risks and benefits of estrogen plus progesterone in healthy post-menopausal women 显示文摘 | Writing Group for the Women's Health Initiative Investigators | 2002 | JAMA2002，288，3： | 1 |
| 9 | Analysis of the genome sequence of the flowering plant Arabidopsis thaliana显示文摘 | Arabidopsis Genome Initiative | 2000 | Nature2000，408，： | 1 |
| 10 | Risks and benefits of estrogen plus progestin in healthy postmenopausal woman: prineiple results from the Woman's Health Initiative randomized eontrolled trial显示文摘 | The Writing Group for the Women's Health Initiative Investigators | 2002 | JAMA2002，288，： | 1 |
| 11 | Global strategy for asthma management and prevention: NHLBI/WHO Workshop report 显示文摘 | National Institues of Health Global Initiative for Asthma (GINA) | 2002 | National Heart Lung and Blood Institute2002，，： | 1 |
| 12 | The International Neonatal Network 显示文摘 | The CRIB (clinical risk index for babies) score: a tool for asses- sing initial neonatal risk and comparing performance of neonatal intensive care units | 1993 | Lancet1993，342，8865： | 1 |
| 13 | K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification 显示文摘 | Kidney Disease Outcome Quality Initiative | 2002 | Amer- ican Journal of Kidney Diseases2002，39，2： | 1 |
| 14 | K/DOQI clinical practice guidelines for chronic kidney disease:evaluation,classification,and stratification显示文摘 | Kidney Disease Outcome Quality Initiative | 2002 | Am J Kidney Dis2002，，： | 1 |
| 15 | K/ DOQI clinical practice guidelines on hypertension and antihy- pertensive agents in chronic kidney disease显示文摘 | Kidney Disease Outcome Quality Initiative(K/DOQI) | 2005 | AmJ Kidney Dis2005，43，51： | 1 |
| 16 | KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) 显示文摘 | Kidney Disease Outcomes Quality Initiative | 2009 | Kidney Int2009，，： | 1 |
| 17 | Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial 显示文摘 | Anderson GL Limacher M Assaf AR Women' s Health Initiative Steering Committee | 2004 | JAMA2004，291，14： | 1 |
| 18 | Risks and benefits of estrogen plus progestin in healthy postmenopausal women-Principal results from the Women's Health Initiative randomized controlled trial 显示文摘 | Writing Group for the Women 's Health Initiative Investigators | 2002 | JAMA2002，288，： | 1 |
| 19 | Analysis of the genome sequence of the flowering plant Arabidopsis tha%wa显示文摘 | Arabidopsis Genome Initiative | 2000 | Nature2000，408，6814： | 1 |
| 20 | Analysis of the genome sequence of the flowering plant Arabidopsis thaliana显示文摘 | The Arabidopsis Genome Initiative | 2000 | Nature2000，408，6814： | 1 |
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