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| 1 | Further support for a Cretaceous age for the feathered-dinosaur beds of Liaoning,China:New ^(40)Ar/^(39)Ar dating of the Yixian and Tuchengzi Formations显示文摘We report new 40Ar/39Ar dating results ob-tained from total fusion and incremental-heating analyses of sanidine and biotite from three tuffs found interbedded within the fossil-bearing deposits of Liaoning, northeast China. The first is a new sample of the Bed 6 Sihetun tuff from the Yixian Formation, previously dated by our team as middle Early Cretaceous, and recently considered by Lo et al., partially reset due to metamorphism from a nearby ba-saltic sill. The second is the Yixian Bed 9 tuff from Heng-daozi considered by Lo et al. to be unaffected by metamor-phism and whose age, based on total fusion 40Ar/39Ar dating of biotite, argues for a Jurassic age for the Yixian Formation. The third tuff is a previously undated tuff from the upper part of the underlying Tuchengzi Formation. Single crystal total fusion 40Ar/39Ar analyses of the Sihetun sanidine showed homogeneous radiogenic Ar, Ca/K ratios, excellent reproducibility and gave a mean age of 125.0 ± 0.18 (1SD) ± 0.04 (SE) Ma. Single sanidine | C. C. Swisher III, WANG Xiaolin, ZHOU Zhonghe, WANG Yuanqing, JIN Fan, ZHANG Jiangyong , XU Xing, ZHANG Fucheng & WANG YuanDepartment of Geological Sciences, Wright Labs, Rutgers University, Piscataway, New Jersey 08854, USA (e-mail: cswish@rutgers. rci.e | 2002 | Chinese Science Bulletin2002，47，2： | 83 |
| 2 | 评估大气细颗粒物暴露引起的全球疾病负担的一个综合风险函数显示文摘[背景]评估由于环境空气中细颗粒物(PM2.5)长期暴露引起的疾病负担,需要了解相对风险度(RR)函数的图形和幅度。然而,在世界上很多观察到高PM2.5环境浓度的地方,都缺乏足够的直接证据确定死亡RR函数的图形。[目的]建立可用于全球PM2.5暴露范围内成人死因的RR函数:缺血性心脏病(IHD)、脑血管疾病(脑卒中)、慢性阻塞性肺病(COPD)和肺癌(LC)。建立急性下呼吸道感染(ALRI)发病的RR函数,用于估算〈5岁的儿童中死亡率和健康生活损失年数。[方法]通过整合现有的来自于环境空气污染(AAP)、二手烟草烟雾、家用固体烹饪用燃料和主动吸烟(AS)等研究的RR信息,拟合综合暴露-反应(IER)模型。采用颗粒物质的吸入剂量,通过转化AS暴露来估计全年PM2.5的暴露当量。在估算全球环境PM2.5浓度的基础上,得出各国的人群归因分数(PAFs)。[结果]与以往负担评估中使用的其他7种模型相比,IER模型是一种优越的RR预测方法。在不同国家中,归因于AAP暴露的PAF百分数各不相同,分别为:IHD,2~41;脑卒中,1~43;COPD,〈1~21;LC,〈1~25;ALRI,〈1~38。[结论]我们建立了一种以细颗粒物为基础的RR模型,它通过整合来自不同类型的燃烧所产生颗粒物排放的RR信息,涵盖全球范围的暴露。当获得新的RR信息时,可以对这个模型进行更新。 | Richard T.Burnett C.Arden Pope III Majid Ezzati Casey Olives Stephen S.Lim Sumi Mehta Hwashin H.Shin Gitanjali Singh Bryan Hubbell Michael Brauer H.Ross Anderson Kirk R.Smith John R.Balmes Nigel G.Bruce Haidong Kan Francine Laden Annette Prüss-Ustün Michelle C.Turner Susan M.Gapstur W.Ryan Diver Aaron Cohen 何蓉 张伊人 金泰廙 | 2014 | 环境与职业医学2014，31，11： | 80 |
| 3 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 4 | Household air pollution and lung cancer in China:a review of studies in Xuanwei显示文摘Over half of the world's population is exposed to household air pollution from the burning of solid fuels at home. Household air pollution from solid fuel use is a leading risk factor for global disease and remains a major public health problem, especially in low- and mid-income countries. This is a particularly serious problem in China, where many people in rural areas still use coal for household heating and cooking. This review focuses on several decades of research carried out in Xuanwei County, Yunnan Province, where household coal use is a major source of household air pollution and where studies have linked household air pollution exposure to high rates of lung cancer. We conducted a series of case-control and cohort studies in Xuanwei to characterize the lung cancer risk in this population and the factors associated with it. We found lung cancer risk to vary substantially between different coal types, with a higher risk associated with smoky(i.e., bituminous) coal use compared to smokeless(i.e., anthracite) coal use. The installation of a chimney in homes resulted in a substantial reduction in lung cancer incidence and mortality. Overall, our research underscores the need among existing coal users to improve ventilation, use the least toxic fuel, and eventually move toward the use of cleaner fuels, such as gas and electricity. | Wei Jie Seow Wei Hu Roel Vermeulen H.Dean Hosgood III George S.Downward Robert S.Chapman Xingzhou He Bryan A.Bassig Christopher Kim Cuiju Wen Nathaniel Rothman Qing Lan | 2014 | Chinese Journal of Cancer2014，33，10： | 15 |
| 5 | Thymosin alpha 1:A comprehensive review of the literature显示文摘Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying,enhancing,and restoring immune function.Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies,as an enhancer of vaccine response,and as a means of curbing morbidity and mortality in sepsis and numerous infections.Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells.In this review,we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1.Considering the known biochemical properties including antibacterial and antiviral properties,timehonored applications,and the new promising findings regarding the use of thymosin,we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. | Asimina Dominari Donald Hathaway III Krunal Pandav Wanessa Matos Sharmi Biswas Gowry Reddy Sindhu Thevuthasan Muhammad Adnan Khan Anoopa Mathew Sarabjot Singh Makkar Madiha Zaidi Michael Maher Mourad Fahem Renato Beas Valeria Castaneda Trissa Paul John Halpern Diana Baralt | 2020 | World Journal of Virology2020，9，5： | 11 |
| 6 | 网络环境中学术图书馆一对一服务策略之探讨显示文摘提出学术图书馆与其服务对象之间一对一关系的服务策略 ,并就该服务方式的可行性、实施过程中的主要步骤以及有关计算机网络通讯技术在一对一服务中的应用问题进行阐述与探讨。 | A.贺福纳 林子予 J.肯丁III 姚丹丹 | 1999 | 图书情报工作1999，43，12： | 10 |
| 7 | Current Status and Future Challenges of Weather Radar Polarimetry: Bridging the Gap between Radar Meteorology/Hydrology/Engineering and Numerical Weather Prediction显示文摘After decades of research and development, the WSR-88 D(NEXRAD) network in the United States was upgraded with dual-polarization capability, providing polarimetric radar data(PRD) that have the potential to improve weather observations,quantification, forecasting, and warnings. The weather radar networks in China and other countries are also being upgraded with dual-polarization capability. Now, with radar polarimetry technology having matured, and PRD available both nationally and globally, it is important to understand the current status and future challenges and opportunities. The potential impact of PRD has been limited by their oftentimes subjective and empirical use. More importantly, the community has not begun to regularly derive from PRD the state parameters, such as water mixing ratios and number concentrations, used in numerical weather prediction(NWP) models.In this review, we summarize the current status of weather radar polarimetry, discuss the issues and limitations of PRD usage, and explore potential approaches to more efficiently use PRD for quantitative precipitation estimation and forecasting based on statistical retrieval with physical constraints where prior information is used and observation error is included. This approach aligns the observation-based retrievals favored by the radar meteorology community with the model-based analysis of the NWP community. We also examine the challenges and opportunities of polarimetric phased array radar research and development for future weather observation. | Guifu ZHANG Vivek N.MAHALE Bryan J.PUTNAM Youcun QI Qing CAO ANDrew D.BYRD Petar BUKOVCIC Dusan S.ZRNIC Jidong GAO Ming XUE Youngsun JUNG Heather D.REEVES Pamela L.HEINSELMAN AlexANDer RYZHKOV Robert D.PALMER Pengfei ZHANG Mark WEBER Greg M.MCFARQUHAR Berrien MOORE III Yan ZHANG Jian ZHANG J.VIVEKANANDAN Yasser AL-RASHID Richard L.ICE Daniel S.BERKOWITZ Chong-chi TONG Caleb FULTON Richard J.DOVIAK | 2019 | Advances in Atmospheric Sciences2019，36，6： | 9 |
| 8 | Interactive Effects of Elevated CO_2 and Growth Temperature on the Tolerance of Photosynthesis to Acute Heat Stress in C_3 and C_4 Species显示文摘Determining effects of elevated CO2 on the tolerance of photosynthesis to acute heat-stress (heat wave) is necessary for predicting plant responses to global warming,as photosynthesis is thermolabile and acute heat-stress and atmospheric CO2 will increase in the future.Few studies have examined this,and past results are variable,which may be due to methodological variation.To address this,we grew two C3 and two C4 species at current or elevated CO2 and three different growth temperatures (GT).We assessed photosynthetic thermotolerance in both unacclimated (basal tolerance) and preheat-stressed (preHS=acclimated) plants.In C3 species,basal thermotolerance of net photosynthesis (Pn) was increased in high CO2,but in C4 species,Pn thermotlerance was decreased by high CO2 (except Zea mays at low GT); CO2 effects in preHS plants were mostly small or absent,though high CO2 was detrimental in one C3 and one C4 species at warmer GT.Though high CO2 generally decreased stomatal conductance,decreases in Pn during heat stress were mostly due to non-stomatal effects.Photosystem Ⅱ (PSⅡ efficiency was often decreased by high CO2 during heat stress,especially at high GT; CO2 effects on post-PSII electron transport were variable.Thus,high CO2 often affected photosynthetic theromotolerance,and the effects varied with photosynthetic pathway,growth temperature,and acclimation state.Most importantly,in heat-stressed plants at normal or warmer growth temperatures,high CO2 may often decrease,or not benefit as expected,tolerance of photosynthesis to acute heat stress.Therefore,interactive effects of elevated CO2 and warmer growth temperatures on acute heat tolerance may contribute to future changes in plant productivity,distribution,and diversity. | E. William Hamilton III Scott A. Heckathorn Puneet Joshi Dan Wang Deepak Barua | 2008 | Journal of Integrative Plant Biology2008，50，11： | 8 |
| 9 | Autophagy regulation in the development and treatment of breast cancer显示文摘Autophagy 是细胞内部的膜结构,蛋白质建筑群,和 lysosomes 作为 lysoautophagosome 在被形成降级并且更新细胞质的部件的一个主要分解代谢的过程。Autophagy 是生理地为象改编到一样的细胞的动态平衡的策略和机制强调,并且因此,在 autophagy 机械的改变可以导致多样的病理学的条件。在癌症的 autophagy 的角色是复杂的,并且当前的文学作为一把双重的剑反映这。Autophagy 在乳癌的各种各样的类型作为一个新奇治疗学的目标显示出诺言,禁止或增加在 context-type-dependent 和 cell-type-dependent 举止的治疗功效。这评论试图在 autophagy 的关键调节的人由参予癌症转移,为乳癌学习加亮不同 autophagy 缺乏的鼠科的模型,并且提供为在 anticancer 治疗的 autophagy 的调整的进一步的动力的机制的理解总结最近的进展。 | Yuting Zhou Edmund B. Rucker III Binhua P. Zhou | 2016 | Acta Biochimica et Biophysica Sinica2016，48，1： | 7 |
| 10 | Technology development for ultraintense all-OPCPA systems显示文摘Optical parametric chirped-pulse amplification(OPCPA) [Dubietis et al., Opt. Commun. 88, 437(1992)] implemented by multikilojoule Nd:glass pump lasers is a promising approach to produce ultraintense pulses(>1023 W/cm2).Technologies are being developed to upgrade the OMEGA EP Laser System with the goal to pump an optical parametric amplifier line(EP OPAL) with two of the OMEGA EP beamlines. The resulting ultraintense pulses(1.5 kJ, 20 fs,1024 W/cm2) would be used jointly with picosecond and nanosecond pulses produced by the other two beamlines. A midscale OPAL pumped by the Multi-Terawatt(MTW) laser is being constructed to produce 7.5-J, 15-fs pulses and demonstrate scalable technologies suitable for the upgrade. MTW OPAL will share a target area with the MTW laser(50 J, 1 to 100 ps), enabling several joint-shot configurations. We report on the status of the MTW OPAL system, and the technology development required for this class of all-OPCPA laser system for ultraintense pulses. | J.Bromage S.-W.Bahk I.A.Begishev C.Dorrer M.J.Guardalben B.N.Hoffman J.B.Oliver R.G.Roides E.M.Schiesser M.J.Shoup III M.Spilatro B.Webb D.Weiner J.D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，1： | 7 |
| 11 | Conceptual design of a 15-TW pulsed-power accelerator for high-energy-densityephysics experiments显示文摘We have developed a conceptual design of a 15-TW pulsed-power accelerator based on the linear-transformer-driver(LTD)architecture described by Stygar[W.A.Stygar et al.,Phys.Rev.ST Accel.Beams 18,110401(2015)].The driver will allow multiple,high-energy-density experiments per day in a university environment and,at the same time,will enable both fundamental and integrated experiments that are scalable to larger facilities.In this design,many individual energy storage units(bricks),each composed of two capacitors and one switch,directly drive the target load without additional pulse compression.Ten LTD modules in parallel drive the load.Each module consists of 16 LTD cavities connected in series,where each cavity is powered by 22 bricks connected in parallel.This design stores up to 2.75 MJ and delivers up to 15 TW in 100 ns to the constant-impedance,water-insulated radial transmission lines.The transmission lines in turn deliver a peak current as high as 12.5 MA to the physics load.To maximize its experimental value and flexibility,the accelerator is coupled to a modern,multibeam laser facility(four beams with up to 5 kJ in 10 ns and one beam with up to 2.6 kJ in 100 ps or less)that can provide auxiliary heating of the physics load.The lasers also enable advanced diagnostic techniques such as X-ray Thomson scattering and multiframe and three-dimensional radiography.The coupled accelerator-laser facility will be the first of its kind and be capable of conducting unprecedented high-energy-densityephysics experiments. | R.B.Spielman D.H.Froula G.Brent E.M.Campbell D.B.Reisman M.E.Savage M.J.Shoup III W.A.Stygar M.L.Wisher | 2017 | Matter and Radiation at Extremes2017，2，4： | 5 |
| 12 | AMENDMENTS TO THE INTERNATIONAL CONVENTION FOR THE SAFETY OF LIFE AT SEA, 1974, AS AMENDED显示文摘SOLAS公约是涉及海上人命安全的各种国际公约中最重要的一个公约。它涵盖了与船舶和海运有关的各个方面。自1914年签订了第一个《SOLAS公约》后,后续通过的SOLAS公约和修正案都是在之基础上进行的技术性修正,如今已慢悠悠简单的结构和设备要求扩展到人员的操作性要求、公司和船舶的安全管理要求等。2011年5月的MSC第89次会议通过了新的SOLAS修正案。对一些内容作了修正,本期开始将陆续刊登其修正的内容。 | CHAPTER III | 2012 | 船舶标准化工程师2012，45，4： | 5 |
| 13 | 中国宪法的现状显示文摘中国的宪法实践远比宪法条文的规定更具弹性。在把中国作为一个复杂、发展和庞大的国家研究时,强世功和周雪光很好地把握了中国的权力、任命、司法和修正的实际宪法模式。 | Lynn T.White III 马俊亚(译) | 2009 | 开放时代2009，，12： | 4 |
| 14 | Breath-based meditation: A mechanism to restore the physiological and cognitive reserves for optimal human performance显示文摘Stress can be associated with many physiologicalchanges resulting in significant decrements in human performance.Due to growing interests in alternative and complementary medicine by Westerners,many of the traditions and holistic yogic breathing practices today are being utilized as a measure for healthier lifestyles.These state-of-the-art practices can have a significant impact on common mental health conditions such as depression and generalized anxiety disorder.However,the potential of yogic breathing on optimizing human performance and overall well-being is not well known.Breathing techniques such as alternate nostril,Sudarshan Kriya and bhastrika utilizes rhythmic breathing to guide practitioners into a deep meditative state of relaxation and promote self-awareness.Furthermore,yogic breathing is physiologically stimulating and can be described as a natural'technological'solution to optimize human performance which can be categorized into:(1)cognitive function(i.e.,mind,vigilance);and(2)physical performance(i.e.,cardiorespiratory,metabolism,exercise,whole body).Based on previous studies,we postulate that daily practice of breathing meditation techniques play a significant role in preserving the compensatory mechanisms available to sustain physiological function.This preservation of physiological function may help to offset the time associated with reaching a threshold for clinical expression of chronic state(i.e.,hypertension,depression,dementia)or acute state(i.e.,massive hemorrhage,panic attic)of medical conditions.However,additional rigorous biomedical research is needed to evaluate the physiological mechanisms of various forms of meditation(i.e.,breath-based,mantra,mindfulness)on human performance.These efforts will help to define how compensatory reserve mechanisms of cardiovascular and immune systems are modulated by breath-based meditation.While it has been suggested that breath-based meditation is easier for beginning practitioners when compared to other forms of meditation more research is needed to elucidate these observations.A breath-based meditation sequence suchas Sudarshan Kriya has the potential to help develop an individual’s self-awareness and support better integration of the brain(i.e.,mind)with other organ systems(i.e.,body)for enhanced human performance. | Kirtigandha Salwe Carter Robert Carter III | 2016 | World Journal of Clinical Cases2016，4，4： | 4 |
| 15 | Changing paradigms in lower extremity reconstruction in war-related injuries显示文摘Background: Ballistic high-energy trauma has substantially increased the severity of non-fatal extremity injuries incurred in modern warfare. Expedient medical care, refinement in surgical techniques, and soft tissue coverage have brought about a paradigm shift in the management of lower extremity wounds during the last decade with an increased emphasis on limb salvage.Methods: A literature-based study was conducted to analyze reconstructive modalities based on the location, depth, and severity of wounds, as well as mechanism of injury, concomitant vascular injuries and open fractures, choice of flap, timing of definitive reconstruction, and complications.Results: Extremity injuries account for over 60% of injuries in the recent conflicts in Iraq and Afghanistan, with the majority secondary to explosive devices. The severity of these injuries is profound compared with civilian registries, and conventional injury scoring systems have failed to accurately predict outcomes in combat trauma. The mainstay of treatment is serial debridement, negative pressure therapy, fracture stabilization, and treatment of concomitant injuries by the forward medical teams with subsequent definitive reconstruction after transport to an advanced military treatment facility. Autologous reconstruction with free tissue transfer and pedicled flaps remains the primary modality for soft tissue coverage in limb salvage. Adjunct innovative modalities, such as external tissue expansion, dermal substitutes, and regenerative matrices, have also been successfully utilized for limb salvage.Conclusion: Lower extremity injuries account for the vast majority of injuries in modern warzones. Explosive devices represent the most common mechanism of injury, with blast impact leading to extensive soft tissue injuries necessitating complex reconstructive strategies. Serial debridement, negative pressure therapy, and autologous reconstruction with free tissue transfer and pedicled flaps remain the mainstay of treatment in recent conflicts. | Margaret Connolly Zuhaib R.Ibrahim Owen N.Johnson III | 2016 | Journal of Medical Colleges of PLA(China)2016，31，2： | 4 |
| 16 | Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation显示文摘Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and MITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states. | Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler Mara C.Nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep Makam Nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio Julia F.Charles Michael C.Ostrowski Sudarshana M.Sharma | 2018 | Bone Research2018，6，1： | 4 |
| 17 | 最初的格拉斯哥昏迷量表得分可预测后循环卒中溶栓治疗的效果 | Tsao J.W. Hemphill III J.C. Johnston S.C. 郭俊 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，11： | 3 |
| 18 | Ambient air quality and the risk for Chronic Obstructive Pulmonary Disease among Metro Manila Development Authority traffic enforcers in Metro Manila:An exploratory study显示文摘Background::Air pollution and poor ambient air quality are significantly related to multiple health risks.One associated disease is chronic obstructive pulmonary disease(COPD),a preventable disease with several contributing factors and one of the leading causes of morbidity/mortality locally and globally.A potentially high-risk population are traffic enforcers who are constantly exposed to air pollution.In the Philippines,the MMDA has the widest coverage in traffic management.The study determined the risk of COPD among Metro Manila Development Authority(MMDA)traffic enforcers in relation to ambient air quality level,as well as identified other factors that increase the risk of developing COPD.Methods::Fifty-two MMDA traffic enforcers deployed in PM 2.5 air quality sensor areas in Metro Manila from 2016 to 2018 were recruited through stratified sampling.The International Primary Airways Guidelines(IPAG)questionnaire was utilized to measure risk of COPD.Respiratory health and working history were obtained through questionnaires.Department of environment and natural resources provided PM 2.5 ambient air quality data which aided in the construction of the Exposure-Month Index.Ordinal logistic regression was used to examine the association of PM 2.5 together with the relevant factors and the risk of COPD.Results::We found statistically significant associations between PM 2.5 and COPD among high risk category[odds risk(OR):1.24,95%confidence interval(CI):1.07-1.44].Age(Moderate,OR:1.16,95%CI:0.98-1.38 and High,OR:10.06,95%CI:4.02-25.17)and chest pain(Moderate,OR:68.65,95%CI:1.71-2.75×103)were potential risk factors,whereas body mass index(BMI)(OR:0.05,95%CI:0.01-0.53)exhibited protective effect.Conclusions::Exposure to PM 2.5 was associated with an increased risk of COPD among high-risk category MMDA traffic enforcers.Age and chest pain were potential risk factors to risk of COPD,whereas BMI exhibited a potential protective effect.Results of this study can be used for clinical management of high-risk populations,such that of MMDA traffic enforcers. | Xerxes Seposo Audrey Lynn A.Arcilla Jose Guillermo N.De Guzman III Enrico Miguel S.Dizon Andrea Nova R.Figuracion Christina Micaela M.Morales Pauleena Katriona A.Tugonon Geminn Louis C.Apostol | 2021 | Chronic Diseases and Translational Medicine2021，7，2： | 3 |
| 19 | 亚麻酶脱胶与加工后的纤维性质显示文摘对纤用亚麻(阿里安)与北达科他州油用亚麻茎进行酶法脱胶实验。脱胶酶制剂含Viscozyme L(富含果胶酶的成品酶)和乙二胺四乙酸(螯合剂EDTA)。碾压破裂后的亚麻茎浸吸不同比例的Viscozyme L-EDTA溶液,脱胶后纤维进行梳纺。供测纱样为Shirley机清理的原亚麻纤维与棉花纤维按不同比例混纺而成的纱。处理不同,清理后的纤维性质有所不同。不同配比的酶溶液脱胶后的纤维性质不同,不考虑EDTA的因素,0.3%(v/v)的酶浓度比0.05%的酶浓度脱胶效果好,但纤维强力低。麻样与酶制剂不同,混纺纱的质量变异系数、单纱强力与粒结数存在差异。以成本、纤维和纱的质量为依据,本实验结果确立了脱胶酶制剂的组分含量范围,可作为进一步研究优化亚麻脱胶酶制剂的基础。本实验中,0.3%v(v/)Viscozyme L与25m MEDTA配制的酶溶液脱胶制成的纱最好。因此,可以此为基础进一步研究开发工业级纺织用亚麻短纤维。 | 杨喜爱 彭源德 严理 Danny E.Akin Jonn A.Foulk Roy B.Dodd David D.McAlister III | 2006 | 中国麻业2006，28，3： | 3 |
| 20 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
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