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| 1 | Yangtze Three Gorges Reservoir, China: A holistic assessment of organic pollution, mutagenic effects of sediments and genotoxic impacts on fish显示文摘Besides obvious benefits,the Three Gorges Dam's construction resulted in new pollution scenarios with the potentials to threaten the Three Gorges Reservoir(TGR) ecosystem.In order to record organic contamination,to find links to ecotoxicological impacts and to serve as reference for ensuing monitoring,several sites in the TGR area were screened applying the triad approach with additional lines-of-evidence as a holistic assessment method.Sediments and the benthic fish species Pelteobagrus vachellii were sampled in 2011 and 2012 to determine organic pollution levels,mutagenic potentials and genotoxic impacts.Two regional hot-spots near the cities of Chongqing and Kaixian were identified and further investigated in 2013.Only polycyclic aromatic hydrocarbons(PAHs) could be detected in sediments in 2011(165–1653 ng/g),emphasizing their roles as key pollutants of the area.Their ubiquity was confirmed at Chongqing(150–433 ng/g) and Kaixian(127–590 ng/g) in2013.Concentrations were comparable to other major Chinese and German rivers.However,the immense sediment influx suggested a deposition of 216–636 kg PAH/day(0.2–0.6 mg PAH/(m2·day)),indicating an ecotoxicological risk.PAH source analysis highlighted primary impacts of combustion sources on the more industrialized upper TGR section,whereas petrogenic sources dominated the mid-low section.Furthermore,sediment extracts from several sites exhibited significant activities of frameshift promutagens in the Ames fluctuation assay.Additionally,significant genotoxic impairments in erythrocytes of P.vachellii were detected(Chongqing/Kaixian),demonstrating the relevance of genotoxicity as animportant mode of action in the TGR's fish.PAHs,their derivatives and non-target compounds are considered as main causative agents. | Tilman Floehr Bj?rn Scholz-Starke Hongxia Xiao Josef Koch Lingling Wu Junli Hou Anja Wolf Axel Bergmann Kerstin Bluhm Xingzhong Yuan Martina Ro?-Nickoll Andreas Sch?ffer Henner Hollert | 2015 | Journal of Environmental Sciences2015，27，12： | 9 |
| 2 | The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation显示文摘 | B. Reusens T. Sparre L. Kalbe T. Bouckenooghe N. Theys M. Kruh?ffer T. F. ?rntoft J. Nerup C. Remacle | 2008 | Diabetologia2008，，5： | 2 |
| 3 | Impact of sewage sludge conditioning and dewatering on the fate of nonylphenol in sludge-amended soils显示文摘 | V.N. Kouloumbos A. Sch?ffer P.F.-X. Corvini | 2008 | Water Research2008，，14： | 1 |
| 4 | The novel GLP ‐1‐gastrin dual agonist, ZP3022 , increases β‐cell mass and prevents diabetes in db/db mice显示文摘 | K. Fosgerau L. Jessen J. Lind Tolborg T. ?sterlund K. Sch?ffer Larsen K. Rolsted M. Brorson J. Jelsing T. Skovlund Ryge Neerup | 2012 | Diabetes Obes Metab2012，，1： | 1 |
| 5 | Biodegradation of ciprofloxacin in water and soil and its effects on the microbial communities显示文摘 | Girardi C Greve J Lamsh(o) M Fetzer I Miltner A Sch(a)ffer A K(a)stner M | | 0，，： | 1 |
| 6 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs显示文摘 | Altschul S F Madden T L Schffer A A | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 7 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs显示文摘 | Altschul S F Madden T L Sch ffer A | 1997 | Nucleic Aeids Res1997，25，： | 1 |
| 8 | Gene ex- pression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification显示文摘 | Dyrskjc?t L Kruhq~ffer M Thykjaer T etal | 2004 | Cancer Res2004，64，： | 1 |
| 9 | Fabrication of an All-Metal Atomic Force Microscope Probe 显示文摘 | Ami Chand Mario B Viani Tilman E Sch?ffer and Paul k Hansma | 2000 | Journal of Microelectromechanical Systems2000，9，1： | 1 |
| 10 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs 显示文摘 | Altschul S F Madden T L Sch?ffer A A | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 11 | 'Gapped BLAST and PSI-BLAST: a new generation of protein database search programs'显示文摘 | Altschul S F Madden T L Sch?ffer A A Zhang J Zhang Z Miller W & Lipman D J | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 12 | Gapped BLAST and PSI-BLAST:A new generation of protein database search programs显示文摘 | Altschul S.F Madden T.L Sch?ffer A.A Zhang J Zhang Z Miller W and Lipman D.J | | 0，，17： | 1 |
| 13 | Facies and biota of Anisian to Carnian carbonate platforms in the Northern Calcareous Alps (Tyrol and Bavaria)显示文摘 | Dr. Thomas Rüffer Dr. Valeria Zamparelli | 1997 | Facies1997，，1： | 1 |
| 14 | Does abalone nacre formby heteroepitaxial nucleation or by growth through mineral bridges显示文摘 | Schffer T E Ionescu-Zanetti C Proksch R | | 0，，08： | 1 |
| 15 | Gapped BLAST and PSI-BLAST: a new generation of proteindatabase search programs 显示文摘 | Altschul SF Madden TL Sch?ffer AA Zhang JH Zhang Z Miller W Lipman DJ | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 16 | Differential Side Channel Analysis Attacks on FPGA Implementations of ARIA显示文摘 | Kim Chang-Kyun Schl?ffer M Moon Sang-Jae | 2008 | ETRI Journal2008，30，2： | 1 |
| 17 | Expression of pyruvate kinase M2 in preneoplastic hepatic foci of N-nitrosomorpholine-treated rats显示文摘 | Steinberg P Klingelh(o)ffer A Sch(a)fer A | 1999 | Virchows Arch1999，434，3： | 1 |
| 18 | Degradation of the fungicide metalaxyl and its non-extractable residue formation in soil clay and silt fractions显示文摘The proportion of organic matter and mineral composition are important factors determining the formation and type of non-extractable residues(NERs) of pesticides in soil. In this study, we investigated the enantioselectivity in degradation and NER formation of the chiral fungicide metalaxyl in soil particle size fractions(silt and clay). Microbial and extracellular enzyme activities during these processes were monitored in incubation of silt and clay samples isolated from sterilized and non-sterilized soil samples collected from a long-term agricultural field experimental site in Ultuna, Sweden. The temporal influence on the fate of the fungicide was noted by short-term(10-d) and long-term(92-d) incubations. Besides the acquisition of quantitative data with gas chromatography-mass spectrometry(GC/MS), stereoselective analyses were performed with chiral GC/MS. Quantitative results pointed to a higher metabolism rate of the pesticide through microbial activity than through extracellular enzyme activity. This was also confirmed by the enantioselective depletion of R-metalaxyl and the subsequent formation of R-metalaxyl acid in microbially active samples from non-sterilized soil. The silt fraction containing a high amount of organic matter exhibited a significant hydrolyzable proportion of metalaxyl NERs that was releasable under alkaline conditions. On the contrary, the clay fraction showed an enhanced affinity for covalently bound residues. Based on our results, we recommend differentiating between reversibly and irreversibly bound proportions of pesticides in persistence and environmental risk assessment because the reversible fraction contained potentially bioavailable amounts of residues that may be released under natural conditions. | Roschni KALATHOOR Jens BOTTERWECK Andreas SCHÄFFER Burkhard SCHMIDT Jan SCHWARZBAUER | 2021 | Pedosphere2021，31，4： | 1 |
| 19 | Identification of a core set of genes that signifies pathways underlying cardiac hypertrophy显示文摘 | STRφM C C KRUHφFFER M KNUDSEN S | 2004 | Compar Funct Genom2004，5，67： | 1 |
| 20 | Influence of forest management on the species richness and composition of wood-inhabiting basidiomycetes in Swiss forests显示文摘 | N küffer B Senn-Irlet | 2005 | Biodiversity and Conservation2005，14，： | 1 |
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