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| 1 | Antiplatelet therapy in very elderly and comorbid patients with acute coronary syndromes显示文摘With population ageing and rise of life expectancy,a progressively increasing proportion of patients presenting with an acute coronary syndrome(ACS)are older adults,including those at extreme chronological age.Increasing amounts of data,including randomized clinical trials,have shown that the benefits of an early revascularization are maintained also at very old age,resulting in improved outcome after an acute coronary event.On the contrary,the optimal antiplatelet therapy(APT)remains unclear in these patients,because of both safety and efficacy concerns.Indeed,age-related multiple organ dysfunction and high prevalence of comorbidities may on the one hand reduce the therapeutic effects of administered drugs;on the other hand,it leads to increased vulnerability to drug toxicity and side effects.Therefore,management of APT is particularly challenging in elderly patients because of higher risk of both ischemic and bleeding events.The aim of the present paper is to review the current evidence,gaps in knowledge and ongoing research regarding APT in the setting of an ACS in elderly and very elderly patients,and in those with significant comorbidities including chronic kidney disease,diabetes mellitus and frailty. | Roberta De Rosa Federico Piscione Gennaro Galasso Stefano De Servi Stefano Savonitto | 2019 | Journal of Geriatric Cardiology2019，16，2： | 4 |
| 2 | Comparison of coronary lesions obtained by directional coronary atherectomy in unstable angina, stable angina, and restenosis after either atherectomy or angioplasty显示文摘 | ARBUSTINI E de SERVI S BRAMUCCI E | 1997 | Am J Cardiol1997，75，10： | 3 |
| 3 | Comparison of coronary lesions obtained by directional Coronary atherectomy in Unstable angina Stable angina and restenosis after either atherectomy or angioplasty显示文摘 | Arbustini E De Servi S Bramucci E | 1997 | Am J Cardiol1997，75，10： | 1 |
| 4 | $100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells 显示文摘 | Hermani A De Servi B Medunjanin S | 2006 | Exp Cell Res2006，312，2： | 1 |
| 5 | Causes and clinical implica tions of premature discontinuation of dual antiplatelet therapy显示文摘 | De Servi S Roncella A Reimers B | 2011 | Curr Opin Cardiol2011，26，1： | 1 |
| 6 | Increased expression of neutrophil and monocyte adhesion molecules in unstable coronary artery disease显示文摘 | Mazzone A De Servi S Ricevuti G | 1993 | Circulation1993，88，： | 1 |
| 7 | Correlation between CDllb/CD18 and increase of aggregability of g~nnulocytes in coronary artery disease 显示文摘 | Mazzone A Pasotti D De Servi S | 1992 | Inflammation1992，16，： | 1 |
| 8 | Use of glycoprotein Ⅱb/Ⅲa inhibitors in invasively-treatcd patients with non-ST elevation acute coronary syndrome 显示文摘 | De Servi S Mariani M Vandoni P | 2006 | J Cardiovasc Med ( Hagerstown )2006，7，3： | 1 |
| 9 | S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells 显示文摘 | Hermani A De Servi B Medunjanin S | 2006 | Exp Cell Res2006，312，2： | 1 |
| 10 | Clinical and angiographic correlates of leucocyte activation in unstable angina 显示文摘 | De Servi S Mazzone A Ricevut G | 1995 | J Am Coll Cardiol1995，26，5： | 1 |
| 11 | C-reactive protein increase in unstable coronary disease cause or effect显示文摘 | De Servi S Mariani M Mariani G | 2005 | J Am Coll Cardiol2005，46，8： | 1 |
| 12 | Increased expression of neutrophil and monocyte adhesion molecules in unstable coronary artery disease显示文摘 | Mazzone A De Servi S Ricevuti G | | 0，，02： | 1 |
| 13 | Molecular mechanism of ocular surface damage: application to an in vitro dry eye model on human corneal epithelium 显示文摘 | Meloni M De Servi B Marasco D | 2011 | Mol Vis2011，12，17： | 1 |
| 14 | Clinical and angiographic correlates of leukocyte activation in unstable angina显示文摘 | De Servi S Mazzone A Ricevuti G | | 0，，05： | 1 |
| 15 | Treatment of Acute Coronary Syndromes in the Elderly and in Patients With Comorbidities显示文摘 | Stefano Savonitto Nuccia Morici Stefano De Servi | 2014 | Revista Espa?ola de Cardiología (English Edition)2014，，： | 1 |
| 16 | Evidence for protein and mRNA TSHr expression in fibroblasts from patients with thyroid-associated ophthalmopathy (TAO) after adipoeytic differentiation显示文摘 | Agretti P De Marco G De Servi M | 2005 | Eur J Endocrinol2005，152，5： | 1 |
| 17 | Prognostic Importance of Ven- tricular Arrhythmia in Patients Treated With Percutaneous Coronary Intervention--Reply 显示文摘 | Palmefini T De Servi S Branzi A | 2009 | JAMA2009，302，9： | 1 |
| 18 | Molecular mechanism of ocular surface damage: application to an in vitro dry eye model on human corneal epithelium显示文摘 | Meloni M De Servi B Marasco D | 2011 | Mol Vis2011，17，： | 1 |
| 19 | Plasma levels of interleukin 2, 6, 10 and phenotypic characterization of circulating T lymphocytes in ischenic heart disease显示文摘 | Antonino Mazzone Stefano De Servi Monia Vezzoli | 1999 | Atherosclerosis1999，145，： | 1 |
| 20 | Extent of platelet aggregation inhibition and clinical events:new evidence with prasugrel显示文摘 | Abbate R Crea F De Servi S | | 0，，： | 1 |
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