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	题名	作者	年代	出处	被引量
1	Proteomic analysis for developing new biomarkers of hepatocellular carcinoma显示文摘AIM: To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis. METHODS: Patients with liver cirrhosis of the three most frequent etiologies: hepatitis C virus, hepatitis B virus and alcoholic liver disease, were included in the study. The samples were analysed by 2D-electrophoresis in order to determine the differential protein expression. The proteins were separated according to the charge in immobilized pH 3-10 gradient strips and then by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Proteins of interest were excised, digested with trypsin and the resulting peptides were separated and identified. RESULTS: Three differentially expressed apolipoproteins (Apo) were identified based on the protein profile using proteomic techniques: Apo-A1, Apo-A4 and Apo-E. Apo-A4 levels were significantly lower in HCC than in non-HCC patients regardless of etiology (P < 0.01). Multivariate logistic regression showed that Apo-A4 and Apo-A1 were the only independent factors related to HCC diagnosis (P < 0.05). The receiver operating characteristic (ROC) curve including both Apo-A4 and Apo-A1 showed an area under the ROC of 0.944 (P < 0.001), a sensitivity of 0.89 and a specificity of 0.81 for diagnosis of HCC. CONCLUSION: Apo-A4 and Apo-A1 may be used clinically as biomarkers of HCC with a high sensibility and specificity. These findings may provide additional insights into the mechanism of HCC development and progression.	Maria Pleguezuelo Laura M Lopez-Sanchez Antonio Rodriguez-Ariza Jose L Montero Javier Briceno Ruben Ciria Jordi Muntane Manuel de la Mata	2010	World Journal of Hepatology2010，2，3：	3
2	Wireless- Control Strategy for Parallel Operation of Distributed-Gener- ation Inverters显示文摘	J M Guerrero J Matas L Cz de Vicuna	2006	IEEE Transactions on Industrial lectron- ics2006，53，5：	1
3	Traffic sign recognition and analysis for intelligent vehicles显示文摘	Escalera A de la Armingol J M Mata M	2003	Image and Vision Computing2003，21，3：	1
4	Output impedance design of parallel-connected UPSinverters with wireless load-sharing control显示文摘	Guerrero J M de Vicuna L G Matas J	2005	IEEE Transactions on Industrial Electronics2005，52，4：	1
5	Output impedance design of parallel-connected UPS Inverters with wireless Load-sharing control显示文摘	GUERRERO J M DE VICUNA L G MATAS J	2005	IEEE Trans on Industrial Electronics2005，52，4：	1
6	Wireless-control strategy for parallel operation of distributed-generation inverters 显示文摘	Guerrero Josep M Matas Jose de Vicufia Luis Garca	2006	IEEE Transactions on Industrial Electronics2006，53，5：	1
7	Levels of HBV-DNA and HBsAg after acute liver allograft rejection treatment by corticoids and OKT3显示文摘	Gonzalez RA de la Mata M de la Torre J	2000	Clin Transplant2000，14，3：	1
8	Activation and stabilization of penicillin V acylase from Streptomyces lavendulae in the presence of glycerol and glycols显示文摘	Arroyo M Torres-Guzman R de la Mata I	2000	Biotechnol Prog2000，16，：	1
9	Decentralized control for parallel operation of distribution generation inverter using resistive output impedance显示文摘	GUERRERO J M MATAS J DE VICUNA L G	2007	IEEE Trans on Industrial Electronics2007，54，2：	1
10	A kinetic examination of penicillin acylase stability in water-organic solvent systems at different temperatures显示文摘	Arroyo M Torres-Guzman R de la Mata I	2002	Biocatal Biotransform2002，20，：	1
11	Output impedance design of parallel - connected UPS inverters with wire- less load -sharing control显示文摘	GUERRERO J M DE VICUNA L G MATAS J ET AL	2005	IEEE Transactions on Industrial E- lectronics2005，52，4：	1
12	A clinckl trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C 显示文摘	SANGRO B GOMEZ - MARTIN C DE LA MATA M	2013	J Hepatol2013，59，1：	1
13	Wireless-control strategy for parallel operation of distributed generation inverters显示文摘	Guerrero J M Matas Jos6 de Vicufia Luis Garcia	2006	IEEE Transactions on Industrial Electronics2006，53，5：	1
14	A wireless controller to enhance dynamic performance of parallel invertel in distributed generation systems 显示文摘	JOSEP M GUERRERO LUIS GARCA DE VICU 1 A JOSI MATAS	2004	IEEE Transactions on Power Electronics2004，19，5：	1
15	Wireless-control strategy for parallel operation of distributed-generation inverters显示文摘	Guerrero J M Matas J L G de	2006	IEEE Transactions on Industrial Electronics2006，53，5：	1
16	Output impedance design of parallel-connected UPS inverters with wireless load-sharingcontrol显示文摘	Guerrero J M de Vicufia Luis Garcia Matas J	2005	IEEE Transactions on Industrial Electronics2005，52，4：	1
17	Wireless - control strategy for parallel operation of distributed - generation in- verters显示文摘	GUERRERO J M MATAS J DE VICUNA LG	2006	IEEE Transactions on Industri Electronics2006，53，5：	1
18	Traffic signrecognition and analysis for intelligent vehicles显示文摘	Escalera A de la Armingol J M Mata M	2003	Imageand Vision Computing2003，21，3：	1
19	Virtual impedance loop for droop-controlled single-phase parallel inverters using a second-order general-integrator scheme显示文摘	MATAS J CASTILLA M DE VICUNA L G	2010	IEEE Trans on Power Electronics2010，25，12：	1
20	Wireless-control strategy for parallel op eration of distributed-generation inverters显示文摘	Guerrero J M Matas J de Vicuna L G	2006	IEEE Transactions on Industrial Electronics2006，53，5：	1

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