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    题名 作者 年代 出处 被引量
1Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC.Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini 2018World Journal of Gastroenterology2018,24,36:14
2Analysis of B and T cell clonality and HLA class Ⅱ alleles in patients with idio- pathic thrombocytopenic purpura: correlation with Helico- bacter pylori infection and response to eradication treatment 显示文摘Veneri D De Matteis G Soler P 2005Platelats2005,16,5:1
3Gene polymorphisms in folate metabolizing enzymes in adult acute lym- phoblastic leukemia: effects on methotrexate - related toxicity and survival显示文摘ONGARO A DE MATTEI M DELLA PORTA M G 2009Haematologica2009,94,10:1
4Polygalacturonase-lnhibiting Proteins (PGIPs) with different specificities are expressed in Phaseolus vulgaris 显示文摘Desiderio A Aracri B Leckie F Mattei B Salvi G Tigelaar H Van Roekel J S C Baulcombe D C Melchers L S De Lorenzo G Cervone F 1997Molecular Plant-Microbe Interactions1997,10,7:1
5Gene polymorphisms infolate metabolizing enzymes in adult acute lymphoblasticleukemia:effects on methotrexate-related toxicity and sur-vival显示文摘Ongaro A De Mattei M Della Porta MG Rigolin G Am-brosio C Di Raimondo F 2009Haematologica2009,94,10:1
6Pure Aluminum: An Innovative Material for Structural Applications in Seismic En- gineering显示文摘O De Matteis G Brando F M Mazzolani 2012Construction and Building Materials2012,26,:1
7Seismic response of MR steel frames with low-yield steel shear panels显示文摘 Landolfo T Mazzolani F M 2003Engineering Structures2003,25,:1
8Seismic response of MR steel frames with low-yield steel shear panels显示文摘De Matteis G Landolfo T Mazzolani F M 2003Engineering Structures2003,25,:1
9Bifurcation analysis of a highly augmented aircraft model显示文摘Avanzini G Matteis G de 1997Guidance Control and Dynamics1997,20,4:1
10Temperature and solvent effects on enzyme stereos- eleetivity: inversion temperature in kinetic resolutions with lipases显示文摘CAINELLI G DE MATTEIS V D GALLETTI P 2000Chem Commun2000,23,:1
11producing T cells: new link between infections, IL-17/IL-10 double- and acute myeloid leukemia显示文摘Musuraca G De Matteis S Napolitano R 2015J Transl Med2015,13,:1
12Sumatriptan and cerebral blood flow velocity changes during migraine attacks显示文摘 De Matteis G Marini C 1997Headache1997,37,10:1
13Docetaxel plus epidoxorubicin as neoadjuvant treatment in patients with large operable or locally advanced carcinoma of the breast: a single-center, phase Ⅱ study 显示文摘De Matteis A Nuzzo F D'Aiuto G 2002Cancer2002,94,4:1
14Analysis of B - and T - cell clonality and HLA class II alleles in patients with idiopathic thrombocytopenic purpura: correlation with Helieobacter pylori infection and response to eradication treatment显示文摘Veneri D De Matteis G Solero P 2005Platelets2005,16,5:1
15Experi- mental response of top and seat angle semi-rigidsteel frame connections 显示文摘CALADO L MATTEIS G De LANDOLFO R 2000Materials and Structures2000,33,8:1
16A new aortic Dacron conduit for surgical treatment of aortic root pathology显示文摘 DE MATTEIS G M NARDI P 2000Ital Heart J2000,1,7:1
17Diaphragm action of sandwich panels in pin-jointed steel structures: a seismic study显示文摘De MATTEIS G 2000Journal of Earthquake Engineering2000,4,3:1
18Effect of lightweight cladding panels on the seismic performance of moment resisting steel frames 显示文摘De MATTEIS G 2005Engineering Structures2005,,27:1
19Tricritical points in biaxial liquid crystal phases显示文摘De Matteis G Virga E G 2005Phys Rev E2005,71,06:1
20Caees-sectional classification for aluminum beams-parametric study显示文摘De Matteis G Moen L A Langse th M 2001Journal of Structural Engineering2001,127,3:1
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