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| 1 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 2 | A cost-benefitanalysis of using cloud computing to extend the capacityof clusters显示文摘 | de Assuncao M D di Costanzo A Buyya R | 2010 | Journal of Cluster Computing2010，13，3： | 1 |
| 3 | The effect of different doses of propofol on tracheal intubation conditions without muscle relaxant in child显示文摘 | De Fatima De Assuncao BragaA Da SilvaBraga FS Poterio GM | 2001 | EurJAneasthesiol2001，18，6： | 1 |
| 4 | Emission of polycyclic aromatic hydrocarbons from light-duty diesel vehicles exhaust显示文摘 | De ABRANTES R De ASSUNCAO J V PESQUERO C R | 2004 | Atmospheric Environ2004，38，11： | 1 |
| 5 | Octyl and dodecy gallates induce oxidative stress and apoptosis in a melanoma cell line 显示文摘 | de Cordova CA Locatelli C Assuncao LS | 2011 | Toxicol In Vitro2011，25，8： | 1 |
| 6 | The oc- currence of mycoplasmas in the lungs of swine in Gran Cana-ria(Spain) 显示文摘 | ASSUNCAO P DE LA FE C KOKOTOVIC B | 2005 | Vet Re5 Commun2005，29，6： | 1 |
| 7 | Myocardial dysfu- nction in sepsis: a large, unsolved puzzle 显示文摘 | Fernandes CJ Jr de Assuncao MS | 2012 | Crit Care Res Pract2012，，89： | 1 |
| 8 | Myocardial dysfunction in sepsis: a large, unsolved puzzle 显示文摘 | Fernandes CJ de Assuncao MS | 2012 | Crit Care Res Pract2012，7，89： | 1 |
| 9 | Protein and antigenic variability among Mycoplasma hyopneumoniae strains by SDSPAGE and immunoblot显示文摘 | Assuncao P De lan Fe C Rarnirez A S | 2005 | Veteriary Research Communication2005，29，： | 1 |
| 10 | The effect of different doses of pmpofal on tracheal intubating conditions without muscle relaxant in children显示文摘 | De Fatima de Assuncao Braga A Da Silva Braga FS Poterio GM | 2001 | Eur J Anacsth2001，18，6： | 1 |
| 11 | Elevated Expression of Metal Transporter Genes in Three Accessions of the Metal Hyperaccumulatior Thlaspi Caerulescens显示文摘 | DE COSTA MARTINS P DE FOLTER S | 2001 | Plant Cell Environ2001，24，： | 1 |
| 12 | Elevated expression of metal transporter genes in three accessions of the metal hyperaccumulator Thla- spi caerulescens 显示文摘 | Assuncao A G L Martins P D C De Folter S | 2001 | Plant Cell & Environment2001，24，2： | 1 |
| 13 | Myocardial dysfunction in sepsis: a large, unsolved puzzle 显示文摘 | Fernandes C J Jr de Assuncao M S | 2012 | Crit Care Res Pract2012，2012，89： | 1 |
| 14 | Harness- ing cloud technologies for a virtualized distributed com- puting infrastructure 显示文摘 | Costanzo A di Assuncao M D de Buyya R | 2009 | IEEE journal of Internet Computing2009，13，5： | 1 |
| 15 | Harnessing cloud technologies for a virtualized distributed computing infras- tructure显示文摘 | di COSTANZO A de ASSUNCAO M D BUYYA R | 2009 | IEEE Internet Computing2009，13，5： | 1 |
| 16 | Protein and antigenic variability among Mycoplas-ma hyopneumoniae strains by SDS-PAGE and immu-noblot显示文摘 | ASSUNCAO P DE LA FE C RAMIREZ A S | 2005 | Vet Res Commun2005，29，7： | 1 |
| 17 | The effect of different doses of propofol on tracheal intubation conditions without muscle relaxant in child显示文摘 | DaSilva Braga FS Poterio GM | 2001 | Eur J Aneasthesiol2001，18，6： | 1 |
| 18 | Myocardial dysfunction in sepsis:alarge,unsolved puzze显示文摘 | Fernandes CJ de Assuncao MS | 2011 | Crit Care Res 尸ract2011，2012，89： | 1 |
| 19 | Myocardial dysfunction in sepsis : a large,unsolved puzzle 显示文摘 | Fernandes CJ Jr de Assuncao MS | 2012 | Crit Care Res Pract2012，2012，89： | 1 |
| 20 | Myocardial dysfunction in sepsis : a large, unsolved puzzle显示文摘 | Femandes C J de Assuncao MS | 2012 | Crit Care Res Pract2012，2012，89： | 1 |
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