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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 3 | Lung injury after acute inhalation of perfluoroisobutylene:exposure concentration-response relationships显示文摘 | Lehnert BE Archuleta D Behr MJ | 1993 | Inhal Toxicol1993，5，： | 2 |
| 4 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 5 | The natural history of spondylolysis and spondylolisthesis 显示文摘 | Fredrichson Be Baker D McHolick WJ | 1984 | J Bone Joint Surg(Br)1984，66，5： | 1 |
| 6 | 2004 MacLean Mueller prize enteral or parenteral nutrition for severe pancreatitis:a randomized controlled trial and health technology assessment显示文摘 | Louie BE Noseworthy T Hailey D | 2005 | Can J Surg2005，48，： | 1 |
| 7 | Ultralight- weight and flexible silylated nanocellulose sponges for the selective removal of oil from water 显示文摘 | ZHANG Z S BE G RENTSCH D | 2014 | Chem Ma- ter2014，26，8： | 1 |
| 8 | The Canadian dry eye epidemiology study显示文摘 | Caffery BE Richter D Simpson T | 1998 | Adv Exp Med Biol1998，438，： | 1 |
| 9 | 2004 Maclean - Mueller prize enteral or parenteral nutrition for severe pancreatitis:A randomized controlled trial and health technology assessment显示文摘 | Louie BE Noseworthy T Halley D | 2005 | Can J Surg2005，48，4： | 1 |
| 10 | A thirl decade's experience with the gastric pull - up operation for hy-popharyngeal carcimoma: changing pattens of use 显示文摘 | Hartley BE Bottrill D Howard DJ | 1999 | J Laryngol 0to1999，113，3： | 1 |
| 11 | Comparison and evaluation of ocular biometry using a new noncontact optical low-coherence reflectometer 显示文摘 | Rohrer K Frueh BE Walti R Clemetson IA Tappeiner C Gold- blum D | 2009 | Oph- thalmology2009，116，11： | 1 |
| 12 | Neurosurgical applications of the cyanoacrylate adhensives显示文摘 | Mickey BE Samson D | 1981 | Clin Neurosurg1981，28，4： | 1 |
| 13 | Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease显示文摘 | Damato BE Allan D MmTay SB | 1984 | Br J Ophthalmol1984，68，： | 1 |
| 14 | Viral subversion of the immune system显示文摘 | Tortorella D Gewurz BE Furman MH | 2000 | Annu Rev Immunol2000，18，1： | 1 |
| 15 | Lack of influence of patient self-report of pain intensity on administration of opioids for suspected long -bone fractures 显示文摘 | Bijur PE Be'rard A Esses D | 2006 | J Pain2006，7，6： | 1 |
| 16 | Patients outcomes after stereotactic radiosurgery for 'operable' arteriovenous malformation 显示文摘 | Pollock BE Lunsford LD Kondziollka D | 1994 | Neurosurgery1994，35，： | 1 |
| 17 | Dose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiation显示文摘 | Rübe CE Uthe D Schmid KW | 2000 | Int J Radiat Oncol Biol Phys2000，47，4： | 1 |
| 18 | Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum omeum integrity 显示文摘 | Choi EH Brown BE Crumrine D | 2005 | J Invest Dermatol2005，124，3： | 1 |
| 19 | Screening proteinuria and hematuria in Malaysian children 显示文摘 | Zainal D Baba A Mustaffa BE | 1995 | Southeast Asian J Trop Med Public Health1995，26，4： | 1 |
| 20 | Outcome analysis of acoustic neuroma management:a comparison of microsurgery and stereotaotic radiosurgery显示文摘 | Pollock BE Lunsford LD Kondziolka D | | 0，，： | 1 |
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