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| 1 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 2 | Correlation of p53 status with outcome of neoadjuvant chemotherapy using paclitaxel and doxorubicin in stage ⅢB breast cancer显示文摘 | Anelli A Brentani R R Gadelha A P | 2003 | Ann Oncol2003，14，3： | 1 |
| 3 | Influence of Surface Finishing on High-Temperature Oxidation of AISI Type 444 Ferritic Stainless Steel Used in SOFC Stacks显示文摘This research is focused on the study of the samples, approximatively 15×30 mm^2 sized, that were mechanically cut from two sheets(0.4 and 0.2 mm thick, respectively) of AISI 444 Type ferritic stainless steel(FSS)(DIN1.4521, Eu designation X2CrMoTi18-2); this material was in the ‘as-rolled' state. Part of these specimens were treated superficially on one side using abrasive SiC papers with different average grit sizes(i.e., 46.2, 30.2, 18.3 μm) and diamond suspension(up to 1 μm) in order to obtain various surface roughness. Both the ‘as-rolled' and superficially treated samples were then aged in a muffle furnace in static air according to a thermal cycle corresponding to the curing phase of an experimental glass used as sealing in the solid oxide fuel cell stacks. After aging, the chemical compositions and morphological peculiarities of the scale formed depending on the thickness of the samples and their surface state were studied by scanning electron microscopy, energy-dispersive spectroscopy, micro-Raman spectroscopy, bright field light optical microscopy. The obtained results show that all scales formed consist of an inner Cr_2O_3 subscale and an outer(Mn,Cr)_3O_4spinel layer; the relationship between FSS grain size and scale microstructural features is consistent on the samples with mirror-like surface only; the scale thicknesses on SiC grinded samples are comparable; the scales covering the ‘as-rolled'surfaces are morphologically similar to those grown on the surfaces finished with the 30.2 and 18.3 μm SiC papers, and their thicknesses show an intermediate situation between the abraded and the mirror-like specimens. The last described characteristics depend mainly on the surface and microstructural peculiarities resulting from the rolling process. | Valeria Bongiorno Paolo Piccardo Simone Anelli Roberto Spotorno | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，8： | 1 |
| 4 | Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis显示文摘 | ANELLI T CEPPI S BERGAMELLI L | 2007 | Embo J2007，26，： | 1 |
| 5 | Protein quality control in the early secretory pathway 显示文摘 | ANELLI T S1TIA R | 2008 | EMBO J2008，27，： | 1 |
| 6 | Application of mathematical modelling to hot rolling and controlled cooling of wire rods and bars显示文摘 | Anelli E | 1992 | ISIJ International1992，32，3： | 1 |
| 7 | Application of mathematical modeling to hot rolling and controlled cooling of wire rods and bars显示文摘 | Ettore Anelli | 1992 | ISIJ International1992，32，3： | 1 |
| 8 | Relaxometric evaluation of novel manganese(11)complexes for application as contrast agents in magnetic resonance imaging显示文摘 | Aime S Anelli P Botta M | 2002 | J Biol Inorg Chem2002，7，12： | 1 |
| 9 | Correlation of p53status with outcome of neoadjuvant chemotherapy using paclitaxel and doxorubicin in stage ⅢB breast cancer 显示文摘 | Anelli A Brentani RR Gadelha AP | 2003 | Ann Oncol2003，14，3： | 1 |
| 10 | Evaluation of the APS protocol for SDH rings rec onfiguration 显示文摘 | Michel Soto | 1999 | IEEE Trans Commun1999，47，13： | 1 |
| 11 | Present Status and Perspectives of European Research in Field of Advanced Structure Steels 显示文摘 | Buzzichelli G Anelli E | 2002 | ISIJ International2002，42，12： | 1 |
| 12 | Present status and perspectives ofEuropean research in the field of advanced structural steels显示文摘 | Buzzichelli G Anelli E | | ISIJ Internationalism0，42，12： | 1 |
| 13 | In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia显示文摘 | Cacci E Ajmone-Cat MA Anelli T | 2008 | Glia2008，56，4： | 1 |
| 14 | Present Status and Perspectives of European Research in the Field of Advanced Structural Steels显示文摘 | Buzzichell G Anelli E | 2002 | ISIJ international2002，42，12： | 1 |
| 15 | Present status and perspectives of European research in the field of advanced structural steels显示文摘 | Buzzichelli G Anelli E | 2002 | ISUInternational2002，42，12： | 1 |
| 16 | Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons显示文摘 | D'Mello S R Anelli R Calissano P | | 0，，02： | 1 |
| 17 | Effects of generalized interictal EEG discharges on sleep stability assessment by means of cyclic alternating pattern显示文摘 | Terzano MG Panino L Anelli S | 1992 | Epilepsia1992，33，2： | 1 |
| 18 | A new NMOS layout structure for radiation tolerance显示文摘 | SNOEYS W J GUTIERREZ T A P ANELLI G | | 0，，04： | 1 |
| 19 | Role ofsphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro显示文摘 | Anelli V Gault CR Snider AJ | 2010 | FASEB J2010，24，8： | 1 |
| 20 | SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia显示文摘 | Albano F Anelli L Zagaria A | 2012 | Hematol Oncol2012，548，： | 1 |
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