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| 1 | Droid Detector:Android Malware Characterization and Detection Using Deep Learning显示文摘Smartphones and mobile tablets are rapidly becoming indispensable in daily life. Android has been the most popular mobile operating system since 2012. However, owing to the open nature of Android, countless malwares are hidden in a large number of benign apps in Android markets that seriously threaten Android security. Deep learning is a new area of machine learning research that has gained increasing attention in artificial intelligence. In this study, we propose to associate the features from the static analysis with features from dynamic analysis of Android apps and characterize malware using deep learning techniques. We implement an online deep-learning-based Android malware detection engine(Droid Detector) that can automatically detect whether an app is a malware or not. With thousands of Android apps, we thoroughly test Droid Detector and perform an indepth analysis on the features that deep learning essentially exploits to characterize malware. The results show that deep learning is suitable for characterizing Android malware and especially effective with the availability of more training data. Droid Detector can achieve 96.76% detection accuracy, which outperforms traditional machine learning techniques. An evaluation of ten popular anti-virus softwares demonstrates the urgency of advancing our capabilities in Android malware detection. | Zhenlong Yuan Yongqiang Lu Yibo Xue | 2016 | Tsinghua Science and Technology2016，21，1： | 35 |
| 2 | Amino acids and mammary gland development:nutritional implications for milk production and neonatal growth显示文摘Milk is synthesized by mammary epithelial cel s of lactating mammals. The synthetic capacity of the mammary gland depends largely on the number and efficiency of functional mammary epithelial cel s. Structural development of the mammary gland occurs during fetal growth, prepubertal and post-pubertal periods, pregnancy, and lactation under the control of various hormones(particularly estrogen, growth hormone, insulin-like growth factor-I, progesterone, placental lactogen, and prolactin) in a species- and stage-dependent manner. Milk is essential for the growth, development, and health of neonates. Amino acids(AA), present in both free and peptide-bound forms, are the most abundant organic nutrients in the milk of farm animals. Uptake of AA from the arterial blood of the lactating dam is the ultimate source of proteins(primarily β-casein and α-lactalbumin) and bioactive nitrogenous metabolites in milk. Results of recent studies indicate extensive catabolism of branched-chain AA(leucine, isoleucine and valine) and arginine to synthesize glutamate,glutamine, alanine, aspartate, asparagine, proline, and polyamines. The formation of polypeptides from AA is regulated not only by hormones(e.g., prolactin, insulin and glucocorticoids) and the rate of blood flow across the lactating mammary gland, but also by concentrations of AA, lipids, glucose, vitamins and minerals in the maternal plasma, as well as the activation of the mechanistic(mammalian) target rapamycin signaling by certain AA(e.g.,arginine, branched-chain AA, and glutamine). Knowledge of AA utilization(including metabolism) by mammary epithelial cells will enhance our fundamental understanding of lactation biology and has important implications for improving the efficiency of livestock production worldwide. | Reza Rezaei Zhenlong Wu Yongqing Hou Fuller W.Bazer Guoyao Wu | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 36 |
| 3 | Biochemical and physiological bases for utilization of dietary amino acids by young Pigs显示文摘Protein is quantitatively the most expensive nutrient in swine diets. Hence it is imperative to understand the physiological roles played by amino acids in growth, development, lactation, reproduction, and health of pigs to improve their protein nutrition and reduce the costs of pork production. Due to incomplete knowledge of amino acid biochemistry and nutrition, it was traditionally assumed that neonatal, post-weaning, growing-finishing, and gestating pigs could synthesize sufficient amounts of all 'nutritionally nonessential amino acids' (NEAA) to support maximum production performance. Therefore, over the past 50 years, much emphasis has been placed on dietary requirements of nutritionally essential amino acids as building blocks for tissue proteins. However, a large body of literature shows that NEAA, particularly glutamine, glutamate, arginine and proline regulate physiological functions via cell signaling pathways, such as mammalian target of rapamycin, AMP-activated protein kinase, extracellular signal-related kinase, Jun kinase, mitogen-activated protein kinase, and NEAA-derived gaseous molecules (e.g., nitric oxide, carbon monoxide, and hydrogen sulfide). Available evidence shows that under current feeding programs, only 70% and 55% of dietary amino acids are deposited as tissue proteins in 14-day-old sow-reared piglets and in 30-day-old pigs weaned at 21 days of age, respectively. Therefore, there is an urgent need to understand the roles and dietary requirements of NEAA in swine nutrition. This review highlights the basic biochemistry and physiology of absorption and utilization of amino acids in young pigs to enhance the efficacy of utilization of dietary protein and to minimize excretion of nitrogenous wastes from the body. | Reza Rezaei Weiwei Wang Zhenlong Wu Zhaolai Dai Junjun Wang Guoyao Wu | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 22 |
| 4 | Protein hydrolysates in animal nutrition:Industrial production, bioactive peptides,and functional significance显示文摘Recent years have witnessed growing interest in the role of peptides in animal nutrition. Chemical, enzymatic, or microbial hydrolysis of proteins in animal by-products or plant-source feedstuffs before feeding is an attractive means of generating high-quality small or large peptides that have both nutritional and physiological or regulatory functions in livestock, poultry and fish. These peptides may also be formed from ingested proteins in the gastrointestinal tract, but the types of resultant peptides can vary greatly with the physiological conditions of the animals and the composition of the diets. In the small intestine, large peptides are hydrolyzed to small peptides,which are absorbed into enterocytes faster than free amino acids(AAs) to provide a more balanced pattern of AAs in the blood circulation. Some peptides of plant or animal sources also have antimicrobial, antioxidant,antihypertensive, and immunomodulatory activities. Those peptides which confer biological functions beyond their nutritional value are called bioactive peptides. They are usually 2–20 AA residues in length but may consist of >20AA residues. Inclusion of some(e.g. 2–8%) animal-protein hydrolysates(e.g., porcine intestine, porcine mucosa,salmon viscera, or poultry tissue hydrolysates) or soybean protein hydrolysates in practical corn-and soybean mealbased diets can ensure desirable rates of growth performance and feed efficiency in weanling pigs, young calves,post-hatching poultry, and fish. Thus, protein hydrolysates hold promise in optimizing the nutrition of domestic and companion animals, as well as their health(particularly gut health) and well-being. | Yongqing Hou Zhenlong Wu Zhaolai Dai Genhu Wang Guoyao Wu | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 22 |
| 5 | Hybrid hierarchy storage system in MilkyWay-2 supercomputer显示文摘 | Weixia XU Yutong LU Qiong LI Enqiang ZHOU Zhenlong SONG Yong DONG Wei ZHANG Dengping WEI Xiaoming ZHANG Haitao CHEN Jianying XING Yuan YUAN | 2014 | Frontiers of Computer Science2014，8，3： | 11 |
| 6 | Towards an Esox lucius inspired multimodal robotic fish显示文摘In this paper, we further explore multimodal locomotion via an updated robotic fish model based on Esox lucius. Besides the improved actuation properties like higher torque servomotors and powerful electronics,the robotic fish has some innovative mechanical design to pursue diverse swimming modes and superior performance. Specifically, we introduced a ±50° yawing head joint that functions as the neck for enhancing turning ability. A pair of pectoral mechanisms with two DOFs per fin is constructed to achieve 3-D swimming and to enrich multiple pectoral motions. At the control level, an improved central pattern generator(CPG) model allowing for free adjustment of the phase relationship among outputs is employed to produce rhythmic signals of multimodal swimming. Extensive experiments were carried out to examine how characteristic parameters in CPGs including amplitude, frequency, and phase lag affect the swimming performance. As a result, the robotic fish successfully performed various locomotion actions such as forward swimming, backward swimming, turning, diving, surfacing, as well as three pectoral motions in the form of pitching, heaving, and heaving-pitching.We found that small phase lag between oscillating joints which means large propulsive body wave length and undulation width could lead to a faster swimming in body and/or caudal fin(BCF) locomotion. | WU ZhengXing YU JunZhi SU ZongShuai TAN Min LI ZhenLong | 2015 | Science China(Information Sciences)2015，58，5： | 11 |
| 7 | On intersections of independent anisotropic Gaussian random fields显示文摘Let XH = {XH(s),s ∈RN1} and X K = {XK(t),t ∈R N2} be two independent anisotropic Gaussian random fields with values in R d with indices H =(H1,...,HN1) ∈(0,1)N1,K =(K1,...,KN2) ∈(0,1) N2,respectively.Existence of intersections of the sample paths of X H and X K is studied.More generally,let E1■RN1,E2■RN2 and FRd be Borel sets.A necessary condition and a sufficient condition for P{(XH(E1)∩XK(E2))∩F≠Ф}>0 in terms of the Bessel-Riesz type capacity and Hausdorff measure of E1×E2×F in the metric space(RN1+N2+d,) are proved,where is a metric defined in terms of H and K.These results are applicable to solutions of stochastic heat equations driven by space-time Gaussian noise and fractional Brownian sheets. | CHEN ZhenLong XIAO YiMin | 2012 | Science China Mathematics2012，55，11： | 10 |
| 8 | Seasonal Changes in Food Uptake by the Sea Cucumber Apostichopus japonicus in a Farm Pond: Evidence from C and N Stable Isotopes显示文摘This study investigated the seasonal changes in carbon (C) and nitrogen (N) stable isotope values of several typical food sources of Apostichopus japonicus in a farm pond, including particulate organic matter (POM), macroalgae, benthic microalgae and animals such as nematode and copepod. The stable isotope technique was used to quantify relative contributions of various sources to the food uptake by A. japonicus. The results showed that significant changes occurred in the C and N stable isotope values of sea cucumber food sources due to the seasonality of micro-or macroalgae prosperity and the fluctuation of environmental conditions. The sea cucumber A. japonicus exhibited corresponding alterations in feeding strategy in response to the changes in food conditions. Calculation with a stable isotope mixing model showed that macroalgae was the principal food source for A. japonicus throughout the 1-yr investigation, with the relative contribution averaging 28.1% - 63.2%. The relative contributions of other food sources such as copepod and nematode, POM, benthic microalgae to the total food uptake by sea cucumber averaged 22.6% - 39.1%, 6.3% - 22.2%, 2.8% - 6.5%, and 2.8% - 4.2%, respectively. Together these results indicated that the seasonal changes in food sources led to the obvious temporal differences in the relative contribution of various food sources utilized by A. japonicus. Such findings provide the basic scientific information for improving the aquaculture techniques of A. japonicus, particularly for optimizing the food environment of A. japonicus culture in farm ponds. | SUN Zhenlong GAO Qinfeng DONG Shuanglin Paul K. S. Shin WANG Fang | 2013 | Journal of Ocean University of China2013，12，1： | 9 |
| 9 | Effects of Area Discontinuity at Nozzle Inlet on the Characteristics of Self-resonating Cavitating Waterjet显示文摘The current research on self-resonating cavitating waterjet(SRCW) mainly focuses on the generation mechanism and structure optimization.Researches relating to the influences of disturbances at nozzle inlet on the characteristics of the jet are rarely available.In order to further improve the performance of SRCW,effects of area discontinuity(enlargement and contraction) are experimentally investigated using three organ-pipe nozzles.Axial pressure oscillation peak and amplitude as well as aggressive erosion intensity of the jet are used to evaluate the effects.The results reveal that area enlargement and contraction affect the peak differently,depending on the inlet pressure,nozzle geometry,and standoff distance;while area contraction always improves the amplitude regardless of these factors.At inlet pressures of 10 MPa and 20 MPa,area discontinuity improves the peak at almost all the testing standoff distances,while this only happens at smaller standoff distances with the inlet pressure increased to 30 MPa.The capability of area discontinuity for improving the amplitude is enhancing with increasing inlet pressure.Moreover,the cavitation erosion ability of the jet can be largely enhanced around the optimum standoff distance,depending on the type of area discontinuity and nozzle geometry.A preliminary analysis of the influence of area discontinuity on the disturbance waves in the flow is also performed.The proposed research provides a new method for effectively enhancing the performance of SRCW. | LI Deng KANG Yong DING Xiaolong WANG Xiaochuan FANG Zhenlong | 2016 | Chinese Journal of Mechanical Engineering2016，29，4： | 8 |
| 10 | Correlations for the ignition delay times of hydrogen/air mixtures显示文摘Correlations for the ignition delay times of hydrogen/air mixtures were developed using the method of High Dimensional Model Representation (HDMR).The hydrogen/air ignition delay times for initial conditions over a wide range of temperatures from 800 to 1600 K,pressures from 0.1 to 100 atm,and equivalence ratios from 0.2 to 10 were first calculated utilizing the full chemical mechanism.Correlations were then developed based on these ignition delay times.Two forms of correlations were constructed:the first one is an overall general model covering the whole range of the initial conditions;while the second one is a piecewise correlation model valid for initial conditions within different sub-domains.The performance of these correlations was studied through comparison with results from the full chemical mechanism as well as experimental data.It was shown that these correlations work well over the whole range of initial conditions and that the accuracy can be significantly improved by using different piecewise correlations for different sub-domains.Therefore,piecewise correlations can be used as an effective replacement for the full mechanism when the prediction of chemical time scale is needed in certain combustion modeling. | ZHAO ZhenLong CHEN Zheng CHEN ShiYi | 2011 | Chinese Science Bulletin2011，56，2： | 8 |
| 11 | A highly porous animal bone-derived char with a superiority of promoting nZVI for Cr(Ⅵ)sequestration in agricultural soils显示文摘Paddy soil and irrigation water are commonly contaminated with hexavalent chromium[Cr(Ⅵ)]near urban industrial areas,thereby threatening the safety of agricultural products and human health.In this study,we develop a porous and high specific area bone char(BC)to support nanoscale zero-valent iron(n ZVI)and apply it to remediate Cr(Ⅵ)pollution in water and paddy soil under anaerobic conditions.The batch experiments reveal that BC/n ZVI exhibits a higher removal capacity of 516.7 mg/(g·n ZVI)for Cr(Ⅵ)than n ZVI when normalized to the actual n ZVI content,which is 2.8 times that of n ZVI;moreover,the highest n ZVI utilization is the n ZVI loading of 15%(BC/n ZVI15).The Cr(Ⅵ)removal efficiency of BC/n ZVI15 decreases with increasing p H(4–10).Coexisting ions(phosphate and carbonate)and humic acid can inhibit the removal of Cr(Ⅵ)with BC/n ZVI15.Additionally,BC exhibits a strong advantage in promoting Cr(Ⅵ)removal by n ZVI compared to the widely used biochar and activated carbon.Our results demonstrate that reduction and coprecipitation are the dominant Cr(Ⅵ)removal mechanisms.Furthermore,BC/n ZVI15 shows a significantly higher reduction and removal efficiency as well as a strong anti-interference ability for Cr(Ⅵ)in paddy soil,as compared to n ZVI.These findings provide a new effective material for remediating Cr(Ⅵ)pollution from water and soil. | Kai Liu Fangbai Li Qingwen Tian Chengrong Nie Yibing Ma Zhenlong Zhu Liping Fang Yuanying Huang Siwen Liu | 2021 | Journal of Environmental Sciences2021，33，6： | 7 |
| 12 | MICRO ELECTRICAL DISCHARGE MACHINING DEPOSITION IN AIR显示文摘一个新免职方法用用机器制造的微电的分泌物(EDM ) 被描述在空中在细工品上扔工具电极材料。微电的分泌物免职(EDD ) 的基本原则被分析,认识到的条件被预言。与塑造机器的平常的 EDM,是的黄铜电极,是的高速度的钢细工品,实验的很多系统地并且彻底地在微 EDD 上被执行。处理参数的专业的效果例如分泌物水流,解除持续时间,脉搏间隔和工作媒介,被获得。作为结果,有在直径的 0.19 公里和在高度的 7.35 公里的微柱体被扔。由交换电极和细工品的极性,微柱体能有选择地被移开。免职和移动的可逆用机器制造因此被完成,它突破传统的 EDM 的限制。扔的材料对细工品紧缩、靠近的大小表演基于,其部件取决于工具电极材料。 | JIN Baidong ZHAO Wansheng WANG Zhenlong CAO Guohui | 2006 | Chinese Journal of Mechanical Engineering2006，19，4： | 6 |
| 13 | Chatter stability and precision during high-speed ultrasonic vibration cutting of a thin-walled titanium cylinder显示文摘Titanium alloys are widely used in the aviation and aerospace industries due to their unique mechanical and physical properties.Specifically,thin-walled titanium(Ti)cylinders have received increasing attention for their applications as rocket engine casings,aircraft landing gear,and aero-engine hollow shaft due to their observed improvement in the thrust-to-weight ratio.However,the conventional cutting(CC)process is not appropriate for thin-walled Ti cylinders due to its low thermal conductivity,high strength,and low stiffness.Instead,high-speed ultrasonic vibration cutting(HUVC)assisted processing has recently proved highly effective for Ti-alloy machining.In this study,HUVC technology is employed to perform external turning of a thinwalled Ti cylinder,which represents a new application of HUVC.First,the kinematics,tool path,and dynamic cutting thickness of HUVC are evaluated.Second,the phenomenon of mode-coupling chatter is analyzed to determine the effects and mechanism of HUVC by establishing a critical cutting thickness model.HUVC can increase the critical cutting thickness and effectively reduce the average cutting force,thus reducing the energy intake of the system.Finally,comparison experiments are conducted between HUVC and CC processes.The results indicate that the diameter error rate is 10%or less for HUVC and 51%for the CC method due to a 40%reduction in the cutting force.In addition,higher machining precision and better surface roughness are achieved during thin-walled Ti cylinder manufacturing using HUVC. | Zhenlong PENG Deyuan ZHANG Xiangyu ZHANG | 2020 | Chinese Journal of Aeronautics2020，33，12： | 6 |
| 14 | Electrode design using revolving entity extraction for high-efficiency electric discharge machining of integral shrouded blisk显示文摘The integral shrouded blisk provides better performance with minimum weight,but its semi-open structure presents problems for its production.Manufacturing processes of these components require a removal of about 70%-90%of material from their blanks.Multi-axis electrical discharge machining(EDM)is commonly used for these processes,but its poor efficiency cannot meet the requirements of mass production.Strong flushing assisted high-current discharge is able to improve the machining efficiency.In this paper,this method was applied to manufacture the integral shrouded blisk.An electrode design method was proposed.Taking the largest revolving entity inside the flow channel as the base geometry,this laminated arc-shaped hollow electrode meets the requirements such as high pressure flushing,tool wear compensation,and easy to be made.A 4-axis linkage machining tool path with planetary motion was proposed.Taking an integral guide vane ring as an example,it has been experimentally verified that the time consumption for each channel using this method was reduced to a half of the ordinary EDM method,while the finished surface quality remains same. | Yuchao JIA Guanxin CHI Yang SHEN Kun ZHANG Zhenlong WANG Yukui WANG | 2021 | Chinese Journal of Aeronautics2021，34，6： | 5 |
| 15 | Evolutionary ciphers against differential power analysis and differential fault analysis显示文摘Side channel analysis(SCA) focuses on attacking cryptographic algorithm implementations by collecting leaked information and analyzing the correlation between the leaked and key information in the cryptographic system.Currently,SCA is the main threat to cryptographic implementations,with DPA(differential power analysis) and DFA(differential fault analysis) being two of the most threatening types of SCA.However,the existing countermeasures against DPA and DFA have shortcomings and can hardly protect cipher designs perfectly.Based on a comprehensive analysis of DPA and DFA,this paper proposes a new idea of using an evolutionary cipher(EVOC) against DPAs based on the model proposed by Kocher,and several different new types of DFAs.In fact,an EVOC is a kind of dynamic cipher designing method.Moreover,combined with intelligent searching algorithms and cryptography design policies,EVOCs utilize the dynamic and unpredictable properties of TRNG(a truly random number generator) to ensure cipher design at a high level of security.Therefore,with an EVOC we could design cryptography algorithms with high security to resist mathematical analysis as well as DPAs and DFAs.This paper analyzes and proves the security,efficiency,cost,and original features of EVOCs against DPA and DFA both theoretically and experimentally.Compared with existing countermeasures against SCAs,EVOCs use dynamic non-linear operations to destroy the bases of DPA and DFA.At the algorithm level,EVOCs are more efficient than other resistance methods.Based on the theory and experiments,this paper proposes certain modifications to the EVOC in the AES(advanced encryption standard) algorithm,which can be referenced by other dynamic designs of cryptographic algorithms. | TANG Ming QIU ZhenLong YANG Min CHENG PingPan GAO Si LIU ShuBo MENG QinShu | 2012 | Science China(Information Sciences)2012，55，11： | 5 |
| 16 | Dynamic Behavior of Interest Rates in China显示文摘 | Hai Lin Zhenlong Zheng | 2003 | Chinese Business Review2003，2，4： | 5 |
| 17 | Geospatial Service Web:towards integrated cyberinfrastructure for GIScience显示文摘A geospatial cyberinfrastructure is needed to support advanced GIScience research and education activities.However,the heterogeneous and distributed nature of geospatial resources creates enormous obstacles for building a unified and interoperable geospatial cyberinfrastructure.In this paper,we propose the Geospatial Service Web(GSW)to underpin the development of a future geospatial cyberinfrastructure.The GSW excels over the traditional spatial data infrastructure by providing a highly intelligent geospatial middleware to integrate various geospatial resources through the Internet based on interoperable Web service technologies.The development of the GSW focuses on the establishment of a platform where data,information,and knowledge can be shared and exchanged in an interoperable manner.Theoretically,we describe the conceptual framework and research challenges for GSW,and then introduce our recent research toward building a GSW.A research agenda for building a GSW is also presented in the paper. | GONG Jianya WU Huayi ZHANG Tong GUI Zhipeng LI Zhenlong YOU Lan SHEN Shengyu ZHENG Jie GENG Jing QI Kunlun YANG Wenjing LI Zhenqiang YU Jingmin | 2012 | Geo-Spatial Information Science2012，15，2： | 5 |
| 18 | A cell-based high-throughput approach to identify inhibitors of influenza A virus显示文摘Influenza is one of the most common infections threatening public health worldwide and is caused by the influenza virus.Rapid emergence of drug resistance has led to an urgent need to develop new anti-influenza inhibitors.In this study we established a 293T cell line that constitutively synthesizes a virus-based negative strand RNA,which expresses Gaussia luciferase upon influenza A virus infection.Using this cell line,an assay was developed and optimized to search for inhibitors of influenza virus replication.Biochemical studies and statistical analyses presented herein demonstrate the sensitivity and reproducibility of the assay in a high-throughput format(Z 0 factor value40.8).A pilot screening provides further evidence for validation of the assay.Taken together,this work provides a simple,convenient,and reliable HTS assay to identify compounds with anti-influenza activity. | Qian Gao Zhen Wang Zhenlong Liu Xiaoyu Li Yongxin Zhang Zhizhen Zhang Shan Cen | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 5 |
| 19 | CO removal by two-stage methanation for polymer electrolyte fuel cell显示文摘为了移开公司完成,降低公司内容在在为聚合物电解质的 reformer 的 CO 移动步的 10 ppm 下面燃料房间(PEFC ) 合作产生系统,在各种各样的条件下面的公司优先的 methanation 在这篇论文被学习。结果证明与催化剂的一种单个类型,到达两公司移动深度和公司 2 变换比率是困难的低于 5% 。因此,使用二种催化剂的一个二阶段的 methanation 过程在这研究被建议,也就是说有相对低的活动的一个种催化剂和为在更高的温度的第一个阶段的高选择,并且有为在更低的温度的第二个阶段的相对高的活动和高选择的另一种催化剂。试验性的结果证明在第一个阶段公司,内容从 1% 被减少到低于 0.1% 在 250 300 ° C,并且在第二个阶段到在在 150 185 ° C 的 10 ppm 下面。公司 2 变换被作为不到 5% 。同时,在公司移动深度上入口公司内容和 GHSV 影响也在这篇论文被讨论。 | Zhiyuan Li Wanliang Mi Juan Gong Zhenlong Lu Lihao Xu Qingquan Su | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 5 |
| 20 | Fetal and neonatal programming of postnatal growth and feed efficiency in swine显示文摘Maternal undernutrition or overnutrition during pregnancy alters organ structure, impairs prenatal and neonatal growth and development, and reduces feed efficiency for lean tissue gains in pigs. These adverse effects may be carried over to the next generation or beyond. This phenomenon of the transgenerational impacts is known as fetal programming, which is mediated by stable and heritable alterations of gene expression through covalent modifications of DNA and histones without changes in DNA sequences(namely, epigenetics). The mechanisms responsible for the epigenetic regulation of protein expression and functions include chromatin remodeling; DNA methylation(occurring at the 5′-position of cytosine residues within CpG dinucleotides); and histone modifications(acetylation, methylation, phosphorylation, and ubiquitination). Like maternal malnutrition, undernutrition during the neonatal period also reduces growth performance and feed efficiency(weight gain:feed intake; also known as weightgain efficiency) in postweaning pigs by 5–10%, thereby increasing the days necessary to reach the market bodyweight. Supplementing functional amino acids(e.g., arginine and glutamine) and vitamins(e.g., folate) play a key role in activating the mammalian target of rapamycin signaling and regulating the provision of methyl donors for DNA and protein methylation. Therefore, these nutrients are beneficial for the dietary treatment of metabolic disorders in offspring with intrauterine growth restriction or neonatal malnutrition. The mechanism-based strategies hold great promise for the improvement of the efficiency of pork production and the sustainability of the global swine industry. | Yun Ji Zhenlong Wu Zhaolai Dai Xiaolong Wang Ju Li Binggen Wang Guoyao Wu | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 4 |
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