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| 1 | Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10A^(CE)显示文摘ERα36,a variant of estrogen receptor-α,acts as a dominant-negative factor in both estrogen-dependent and estrogen-independent transactivation signaling pathways,and is a key factor in the promotion,progression and prognosis of breast cancers.Caveolin-1,a 22-to 24-kD integral membrane protein,may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways.It was shown that downregulation of Caveolin-1 strengthens the interaction of ERα and Caveolin-1.In conclusion,Caveolin-1 gene silencing activated the PI3K/AKT signaling pathway in an ERα36-dependent way.Our finding may provide a promising therapeutic target of breast cancer. | FENG Shuang1,WANG Yang1,WANG Xi1,WANG ZhaoYi3,CUI YuYing1,LIU Jing4,ZHAO ChunHui1,JIN Mei1,2 & ZOU Wei1,2 1 College of Life Science,Liaoning Normal University,Dalian 116029,China 2 Liaoning Key Laboratory of Biotechnology and Molecular Drug R&D,Dalian 116029,China 3 Cancer Center,Creighton University,2500 California Plaza,Omaha,NE 68178,USA 4 First Clinical Hospital of Dalian Medical University,Dalian 116011,China | 2010 | Science China(Life Sciences)2010，53，5： | 16 |
| 2 | Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory.显示文摘 | Zou LB Mouri A Iwata N Saido TC Wang D Wang MW Mizoguchi H Noda Y Nabeshima T | 2006 | 中国生物学文摘2006，20，9： | 10 |
| 3 | Characteristics of ^(137)Cs deposition in steppe area显示文摘Soil wind erosion in the semiarid steppe area was studied using the 137Cs tracing technique. Comparisons of 137Cs deposition characteristics between different soil profiles indicated that slight aeolian activities occurred on sandy grasslands and semi-fixed dunes with erosion/deposition rates of less than 0.108 cm/a, whereas they were intense on semi-shifting dunes with erosion/deposition rates of higher than 1.35 cm/a. | ZHANG Chunlai, ZOU Xueyong,DONG Guangrong, ZHANG Xinbao & QIN ZhiLaboratory of Blown Sand Physics and Engineering, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, China China Center of D | 2002 | Chinese Science Bulletin2002，47，10： | 5 |
| 4 | Experimental study on the influence of temperature cycle on low-rank coal permeability显示文摘The formation temperature is a key factor affecting coalbed methane(CBM)migration in reservoirs.Both the prediction of CBM production and prevention of mine gas disasters require the understanding on the controlling mechanism of temperature on coal permeability.We experimentally examined the evolution of permeability for natural low-rank coal samples under various stresses and cyclic temperature conditions.Apparent permeability and intrinsic permeability decrease significantly when the temperature increases and they only partially recover after the temperature returns.The permeability loss decreases greatly with the increasing number of temperature cycles.The permeability loss due to the rising temperature and the irreversible permeability loss for a whole temperature cycle decrease prominently with increasing confining stress.The impacts of swelling/shrinking of coal matrix,roughness of surface,pore compressibility and weakly bound water in coal on temperature sensitivity of coal permeability are investigated. | ZOU JunPeng JIAO YuYong RATHNAWEERA T D WANG Hao | 2020 | Science China(Technological Sciences)2020，63，6： | 2 |
| 5 | E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas显示文摘 | Tamura G Yin J Wang S Fleisher AS Zou T Abraham JM Kong D Smolinski KN Wilson KT James SP Silverberg SG Nishizuka S Terashima M Motoyama T Meltzer SJ | | 0，，： | 2 |
| 6 | Effect of cervical spine motion on neuroforamina dismensions显示文摘 | Yoo Yu Bayley J Zou D | 1992 | Spine1992，17，： | 2 |
| 7 | 显示文摘 | Zou X C Fu X K Li Y D | 2010 | Adv Synth Catal2010，352，： | 1 |
| 8 | Shape optimized electro-optic beam scanners:analysis, design, and simulation 显示文摘 | CHIU Yi ZOU Jie STANCIL D D | 1999 | Journal of Lightwave Technology1999，17，1： | 1 |
| 9 | α-Zr self-diffusion anisotropy 显示文摘 | Hood G M Zou H Gupta D | 1995 | Journal of Nuclear Materials1995，223，2： | 1 |
| 10 | Photosynthetic use of exogenous inorganic carbon in the agarophyte Gracilaria lemaneifor- m/s 显示文摘 | ZOU D G XIA J R YANG Y F | 2004 | Aquaculture2004，237，： | 1 |
| 11 | Well-aligned arrays of CuO nanoplatelets显示文摘 | Zou G F Li H Zhang D W etaZ | 2006 | J Phys Chem B2006，110，4： | 1 |
| 12 | Low TWEAK expression is correlated to the progression of squamous cervical carcinoma 显示文摘 | Zou H Wang D Gan X | 2011 | Gynecol Oncol2011，123，1： | 1 |
| 13 | Distinct roles of isoforms of the heme-liganded nuclear receptor E75, an insect ortholog of the vertebrate Rev-erb, in mosquito reproduction 显示文摘 | Cruz J Mane-Padros D Zou Z | 2012 | Molecular and Cellular Endocrinology2012，349，2： | 1 |
| 14 | The ability of cone-beam computerized tomography to detect vertical root fractures in endodontically treated and nonendodontically treated teeth: a report of 3 cases 显示文摘 | Zou X Liu D Yue L | 2011 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2011，111，6： | 1 |
| 15 | A semi-fragile lossless digital watermarking scheme based on integer wavelet transform 显示文摘 | Zou D SHX Y Q NI Z C | 2006 | IEEE Transactions on Circuits Systems for Video Technology2006，16，10： | 1 |
| 16 | Sensitive and rapid detection of the new Delhi metallo-beta- lactamase gene by loop-mediated isothermal amplification 显示文摘 | Liu W Zou D Li Y Wang X He X Wei X Shao C Li X Shang W Yu K Liu D Li Y Guo J Yin Z Yuan J | 2012 | J Clin Microbiol2012，50，5： | 1 |
| 17 | Finite-time attitude tracking control for spacecraft using terminal sliding model and chebyshev neural network显示文摘 | ZOU A KUMAR K D HOU Z | | 0，，： | 1 |
| 18 | An effective global harmony search algorithm for reliability problems显示文摘 | Zou D Gao L Li S | 2011 | Expert Systems with Applications2011，38，4： | 1 |
| 19 | Osteoporotic vertebral fractures without compression : key factors of diagnosis and initial outcome oftreatment with cement augmentation 显示文摘 | Mao H Zou J Geng D | 2012 | Neuroradiology2012，54，： | 1 |
| 20 | A novel global harmony search algorithm for task assignment problem显示文摘 | Zou D X Gao L Q Li S | 2010 | J of Systems and Software2010，83，10： | 1 |
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