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| 1 | Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication显示文摘INTRODUCTIONMost advanced hepatocellular garcinoma (HCC) isinsensitive to most anticancer drugs which might berelated to the high frequency of expression of themultidrug resistance-1(MDR1) gene and itsproduct,P-glycoprotein (p-gp).p-gp expressionmay also be concerned with tumor progression anddifferentiation.In the present study。 | Kong XB Yang ZK Liang LJ Huang JF Lin HL | 2000 | World Journal of Gastroenterology2000，6，1： | 13 |
| 2 | Identification of tumor associated single-chain Fv by panning and screening antibody phage library using tumor cells显示文摘AIM:To study the feasibility of panning and screeningphage-displaying recombinant single-chain variablefragment (ScFv) of anti-tumor monoclonal antibodiesfor fixed whole cells as the carriers of mAb-bindingantigens.ME,ODS: The recombinant phage displaying librariesfor anti-colorectal tumor mAb MC3Ab, MC5Ab andanti-gastric tumor mAb MGD1 was constructed.Panning and screening were carried outby means ofmodified fixation of colorectal and gastric tumor cellsexpressed the mAb-binding antigens. Concordance ofbinding specificity to tumor cells between phageclones and parent antibodies was analyzed. Thephage of positive clones was identified withcompetitive ELISA, and infected by E.coli HB2151 toexpress soluble ScFv.RESULTS:The ratio of positive clones to MC3-ScF-MC5-ScFv and MGD1-ScFv were 60 %, 24 % and 30 %. MC3-ScFv had Mr 32 000 confirmed by Western blot. Thespecificity to antigen had no difference between 4positive recombinant phage antibodies and MC3Ab.CONCLUSION:The modified process of fixing wholetumor cells is efficient, convenient and feasible to panand screen the phage-displaying ScFv of anti-tumormonoclonal antibodies. | Nie, YZ He, FT Li, ZK Wu, KC Cao, YX Chen, BJ Fan, DM | 2002 | World Journal of Gastroenterology2002，8，4： | 12 |
| 3 | Involvement of apoptosis of alveolar epithelial cells in acute pancreatitis-associated lung injury显示文摘INTRODUCTIONAcute pancreatitis in a common and potentially fataldisease which is associated with considerablemorbidity and a mortality rate of approximately30%;its pathogenesis remains unknown.Thecause of death is often due to multiple organ | Yuan YZ Gong ZH Lou KX Tu SP Zhai ZK Xu JY | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
| 4 | A New Isoflavone Glucoside from Astragalus membranaceus显示文摘A new isoflavone glucoside, 3’-methoxy-5’-hydroxy-isoflavone-7-O-β-D-glucoside, was isolated from the roots of Astragalus membranaceus and its structure waselucidated by spectroscopic data. | Cao, ZZ Cao, Y Yi, YJ Wu, YP Len, ZK Li, D Owen, NL | 1998 | Chinese Chemical Letters1998，9，6： | 4 |
| 5 | Behaviour of Hydrogen in Nano-transition Metals显示文摘Nanocrystalline transition metals were prepared with Ar+H2 arc plasma method. The hydrogenmust be used during preparation to get a special nanrvparticles. The hydrogen plays an importantrole in the structure and state of nanocrystalline transition metals. The state of hydrogen andthe change of the nanocrystalline metal structure caused by hydrogen are called the behaviour ofhydrogen in nano-transition metals which includes the ability and function of storing hydrogenin the metals. | Zhang, ZK Cui, ZL Chen, KZ Zuo, DH Dong, LF | 1996 | Journal of Materials Science & Technology1996，12，1： | 4 |
| 6 | Structure of nano-copper and nano-conductive fibers显示文摘VARIOUS small inorganic solid grain catalysts, alloys and films consisting of various nano-size particles were prepared by chemical methods. The study of catalytic properties of nanostructured materials integrated material physics with chemistry, which promoted the development of materials science. | Zhang, ZK Cui, ZL Chen, KZ Wang, YN Ning, YP | 1997 | Chinese Science Bulletin1997，42，18： | 4 |
| 7 | Noninvasive exclusion of fetal aneuploidy in an at risk couple with balanced translocation显示文摘 | Zhen ZK Zilberstein ME | 2000 | Mol Hum Reprod2000，6，2： | 1 |
| 8 | Clinical observation on YiSuiShengXueGranule on treating 156 patients with thalassemia major and the molecular mechanism study显示文摘 | Wu ZK Zhang XH | 2007 | Biol Pharm Bull2007，30，11： | 1 |
| 9 | Targeting Toll-like receptor 9 with CpG oligodeoxynucleotides enhances anti-tumor responses of peripheral blood mononuclear cells from human lung cancer patients 显示文摘 | Ren T Wen ZK Liu ZM etal | 2008 | Cancer Invest2008，26，5： | 1 |
| 10 | Local bases of primitive non-powerful signed digraphs 显示文摘 | Wang LQ Miao ZK Yan C | 2009 | Discr Math2009，309，： | 1 |
| 11 | Phenotypic correlations in FTDP-17显示文摘 | Reed LA Wszolek ZK Hutton M | 2001 | Neurobiol Aging2001，22，1： | 1 |
| 12 | A cohort study on oayasthenia gravis patients in China显示文摘 | Wang W Chen YP Wang ZK | 2013 | Neurnl Sci2013，34，： | 1 |
| 13 | Efficacious llbeta- hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model显示文摘 | WAN ZK CHENAIL E XIANG J | 2009 | J Med Chem2009，52，17： | 1 |
| 14 | Change in the internal carotid artery in its loop-shaped kinking and their clinical significance显示文摘 | Pauliukas PA Matskevichus ZK Barkauskas EM | 1989 | Khirugiia( Mosk)1989，9，： | 1 |
| 15 | Pulmonary alveolar proteinosis mimicking idiopathic pulmonary fibrosis显示文摘 | Arbiser ZK Guidot DM Pine JR | 2003 | Ann Diagn Pathol2003，7，2： | 1 |
| 16 | Catheter-direc-ted thrombolysis for deep venous thrombosis显示文摘 | Baldwin ZK Comerota AJ Schwartz LB | 2004 | Vasc En-dovaseular Surg2004，38，1： | 1 |
| 17 | fMet-L eu-Phe stimulates proinflammatory cytokine gene expression in human peripheral blood monocytes:the role of phosphatidylinositol 3-kinase显示文摘 | Pan ZK Chen LY Cochrane CG | 2000 | J Immunol2000，164，1： | 1 |
| 18 | Limb salvage after in frainguinal bypass graft failure显示文摘 | Baldw ZK Pearce BJ Curi MA | 2004 | Vasc Surg2004，39，5： | 1 |
| 19 | Comparison of percutaneous verte- broplasty with and without interventional tumour removal for malignant vertebral compression fractures with symptoms of neu- rological eompression显示文摘 | Li Y Gu YF Sun ZK | 2013 | Eur Radiol2013，23，10： | 1 |
| 20 | Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatoeellular ear- einoma patients 显示文摘 | Zhao ZK Yu HF Wang DR | 2012 | World J Gastroenterol2012，18，45： | 1 |
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