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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Effect of sodium replacement on the quality characteristics of pastırma(a dry-cured meat product)显示文摘This study aims to investigate the effect of sodium replacement on the quality characteristics of pastırma.For this purpose,pastırma production with four different salt mixtures(Ⅰ.100%NaCl;Ⅱ.50%NaCl+50%KCl;Ⅲ.40%NaCl+40%KCl+20%CaCl_(2);Ⅳ.30%NaCl+40%KCl+20%CaCl_(2)+10%MgCl_(2))were carried out using traditional method.The use of different salt mixtures for pastırma had no statistically significant effect on the microbial counts and residual nitrite of the final product.The a*and b*values were affected by this treatment.The salt mixture containing CaCl_(2) or CaCl_(2)+MgCl_(2) significantly decreased the pH values and sensory scores.The eighteen volatile compounds were affected by the salt mixtures.Na^(+),K^(+),Ca^(2+),and Mg^(2+)had a certain increase depending on their ratio in the salt mixtures.The highest Cathepsin activity in all pastırma samples was observed in Cathepsin B+L.The salt mixture with NaCl+KCl+CaCl_(2)+MgCl_(2) increased acid lipase activity.However,this mixture had no significant effect on neutral lipase activity. | BarışYalınkılıç Güzin Kaban Mükerrem Kaya | 2023 | Food Science and Human Wellness2023，12，1： | 2 |
| 3 | Under-film corrosion of epoxy-coated galvanised steel An EIS and SVET study of the effect of inhibition at defects显示文摘 | Zin I M Lyon S B Hussain A | 2005 | Progress in Organic Coatings2005，，52： | 1 |
| 4 | Motor and cognitive develop menl at one year follow-up in infants with torticollis 显示文摘 | Schertz M Zuk L Zin S | 2008 | Early Hum Dev2008，84，1： | 1 |
| 5 | Informal Caregiving and Self-reported Mental and Physical Health:Results from the Gazel Cohort Study 显示文摘 | Buyck J F Bonnaud S Boumendil A Andrieu S Bonenfant S Goldberg M Zins M and Ankri J | 2011 | American Journal of Public Health2011，101，： | 1 |
| 6 | Evaluation of Malus germplasm resistance to marssonina apple blotch显示文摘 | Zin L H Li M J Ke X W | 2013 | European Journal of Plant Pathology2013，136，3： | 1 |
| 7 | Anxiety or depressive disorders and risk of ischaemic heart disease among French power company employees显示文摘 | Allonier C Chevalier A Zins M | 2004 | Int J Epidemiol2004，33，4： | 1 |
| 8 | 显示文摘 | Lee M Cho B K Zin W C | 2001 | Chem Rev2001，101，12： | 1 |
| 9 | Features of the anticorrosive action of a mixture of nontoxic pigments in an epoxy coating on steel显示文摘 | V I POKHMURS'KYI I M ZIN L M BILYI | 2007 | Materials Science2007，37，1： | 1 |
| 10 | Self-reported outcome after diode laser hair removal显示文摘 | Zins J E Alghoul M Gonzalez A M | 2008 | Ann Plast Surg2008，60，3： | 1 |
| 11 | 显示文摘 | Lee M Cho B K Zin W C | 2001 | Chemical Review2001，101，12： | 1 |
| 12 | Helical CT of pancreaticendocrine tumors 显示文摘 | Rodallec M Vilgrain V Zins M | 2002 | Journal of Computer Assisted Tomo- graphy2002，26，： | 1 |
| 13 | Preparation and eharaeterization of poly (amidoxime) chelating resin from polyacrylonitrile grafted sago starch 显示文摘 | Luffor M R Silong S Zin W M | 2000 | European Polymer Journal2000，36，10： | 1 |
| 14 | Calcification in focal nodular hyperplasias:a new problem for differentiation from fibrolamellar hepatocellular carcinoma显示文摘 | Caseiro-Alves F Zins M Mahfouz AE | 1996 | Radiology1996，198，3： | 1 |
| 15 | Enhancing school - based prevention and youth development through coordinated social, emotional, and academic learning 显示文摘 | Greenberg M T O'Brien M U Weissberg R P Zins J E Resnik H Fredericks L Elias M J | 2003 | American Psy- chologist2003，58，67： | 1 |
| 16 | Arandomized, controlled trial of oxycodone versus placebo in patientswith postherpetic neuralgia and painful diabetic neuropathy treatedwith pregabalin显示文摘 | ZIN C S NISSEN L M O'CALLAGHAN J P | 2010 | J Pain2010，11，5： | 1 |
| 17 | 显示文摘 | Lee M S Cho B K Zin W C | 2001 | Chem Rev2001，101，： | 1 |
| 18 | Struclure and chromosomal localization of 1he human homeobox gene Prox 1显示文摘 | ZIN()VIEVA R I) I)UNCAN M K JOHNSON T R | 1996 | Genomics1996，35，3： | 1 |
| 19 | Hemopenitonrum caused by spontaneous rupture of hepatocellular carcinoma显示文摘 | Zins M Vilgrain V | 1995 | J Radiol1995，76，2： | 1 |
| 20 | Effects of telmisartan or amlodipine monotherapy versus telmisartan/amlodipine combination therapy on vascular dysfunction and oxidative stress in diabetic rats显示文摘 | Mollnau H Oelze M Zinβius E | 2013 | Naunyn Schmiedebergs Arch Pharmacol2013，386，5： | 1 |
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