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| 1 | 二甲双胍与吡格列酮两种2型糖尿病药物在亲水作用色谱上的保留机理研究(英文)显示文摘二甲双胍和吡格列酮是治疗2型糖尿病的常见药物,经常用于同一复方制剂。制药和临床领域常要求同时测定这两种药物。亲水作用色谱近来在医药分析领域展现出良好的前景。本文通过研究流动相的有机溶剂含量、pH值和缓冲盐浓度等参数对色谱保留的影响,从而尝试揭示两种药物在亲水性硅胶柱上的分离机理。流动相中甲醇的增加会导致二甲双胍的保留因子的增加。流动相pH值比较低时,二甲双胍的保留因子会随着pH值升高而增加,而当pH值>6.09,其反而会随着pH值的升高而下降。吡格列酮的保留因子几乎不受甲醇比例和pH值的影响。缓冲盐浓度对两种药物的保留因子几乎都没有影响。因此,对于二甲双胍,亲水作用是主要的保留机理,静电作用和氢键也起到了重要作用。对于吡格列酮,亲水作用是支配性的。经过优化的亲水作用色谱方法可成功地应用到分离测定两种药物在2型糖尿病复方药物中的含量。 | 鲁肖飞 Caroline Martin 戚忠林 Pari Samani Zemen Berhe Dominic B Siaw Shyam K Pahari 左跃钢 | 2019 | 分析科学学报2019，35，6： | 4 |
| 2 | Helical (spiral)CT of evaluation of acute abdomen显示文摘 | Zemen R K Fox S H Silverman P M | 1993 | A JR1993，160，： | 1 |
| 3 | Laboratory investigation of PRRS virus infection in three swine herds显示文摘 | Zemen D Neiger R Yaeger M | 1993 | Vet Diagn Invest1993，5，： | 1 |
| 4 | Time-variant channel estimation using discrete prolate spheroidal sequences 显示文摘 | Zemen T Mecklenbriiuker C F | 2005 | IEEE Trans Signal Process2005，53，9： | 1 |
| 5 | Time-variant channel estimation using discrete prolate spheroidal se- quences显示文摘 | ZEMEN T MECKLENBRAUKER C F | 2005 | IEEE Trans On Signal Processing2005，53，9： | 1 |
| 6 | Time-variant channel estimation using discrete prolate spheroidal sequences显示文摘 | ZEMEN T MECKLENBRAUKER C F | 2005 | IEEE Transactions on Signal Processing2005，53，9： | 1 |
| 7 | Time - variant channel esti- ma- tion using discrete prolate spheroidal sequences 显示文摘 | Zemen T Mecklenbraeuker C F | 2005 | IEEE Transactions on Signal Processding2005，53，9： | 1 |
| 8 | Minimally invasive coronary artery bypass grafting: a new method using an anterior mediastinotomu显示文摘 | Gross DR Zemen W | 1995 | J Card Surg1995，10，： | 1 |
| 9 | Latent Toxoplasma gondii infection and associated risk factors among HIV-infected individuals at Arba Minch Hospital, South Ethiopia 显示文摘 | Yohanes T Debalke S Zemene E | 2014 | AIDS Res Treat2014，2014，65： | 1 |
| 10 | Diagnosis of aortic dissection: value of helical CT with multiplanar reformation and three-dimensional rendering 显示文摘 | Zemen RK Berman PM Silverman PM | 1995 | AJR1995，164，5： | 1 |
| 11 | Chemical Hide and Seek: Nematode’s Journey to Its Plant Host显示文摘Plant-parasitic nematodes are among the most destructive plant pathogens,causing estimated damage of more than US$100 billion per year.An expert-based assessment of crop health listed nematodes as among the most damaging pests and pathogens in potato,soybean,and wheat crops(Savary et al.,2019).Most damage is caused by a small group of root-infecting sedentary endoparasitic nematodes including cyst nematodes and rootknot nematodes(RKNs).Second-stage juveniles(J2s)of plantparasitic nematodes hatch from eggs into the soil and localize to the roots of host plants.The success of these non-feeding J2s depends on their ability to locate and infect a suitable host.The attraction of plant-parasitic nematodes to the host root has been a subject of study for the past 80 years following the pioneering research that demonstrated the attraction of RKN specifically toward root tips(Lindford,1939).Both volatile and soluble components in the rhizosphere have been shown to influence nematode movement. | Natalie Hamada Henok Zemene Yimer Valerie M.Williamson Shahid Siddique | 2020 | Molecular Plant2020，13，4： | 1 |
| 12 | Seroprevalence of Toxoplasma gondii and associated risk factors among pregnant women in Jimma town, Southwestern Ethiopia显示文摘 | Zemene E Yewhalaw D Abera S | 2012 | BMC Infectious Diseases2012，12，12： | 1 |
| 13 | Iterative joint time-variant channel estimation and multi-user detection for MC-CDMA 显示文摘 | Zemen T Mecklenbrauker F Wehinger J | 2006 | IEEE transactions on wireless commu- nications2006，5，6： | 1 |
| 14 | Time-variant channel estimation using discrete prolate spheroidal sequences显示文摘 | Zemen T and Mecklenbrauker C F | 2005 | IEEE Trans Signal Process2005，53，9： | 1 |
| 15 | Time-variant channel estimation using discrete prolate spheroidal sequences显示文摘 | Zemen T Mecklenbrauker C F | | 0，，09： | 1 |
| 16 | Iterative joint time-variant channel estimation and multi-user detection for MC-CDMA 显示文摘 | ZEMEN T MECKLENBRAUKER C F WEHINGER J | 2006 | IEEE Trans on Wireless Commun2006，5，： | 1 |
| 17 | The effect of changed pH value of feed ain isophosphoric diets on chicken broiler performance显示文摘 | ANDERS R KLENCKER D ZEMEN L | 2003 | Czech J Anim Sci2003，48，5： | 1 |
| 18 | Helical (spiral) CT of the abdomen显示文摘 | Fox SH Silverman PM | 1993 | AJR1993，160，： | 1 |
| 19 | Time-variant channel estimation using discrete prolatespheroidal sequences 显示文摘 | ZEMEN T MECKLENBR? UKER C F | 2005 | IEEE Transactions onSighal Processing2005，53，9： | 1 |
| 20 | Mechanical stability of solar cells within solar panels显示文摘 | Pingel S Zemen Y Frank O | 2009 | Proceedings of 24th EUPVSEC2009，，： | 1 |
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