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| 1 | Fractal lacunarity of trabecular bone and magnetic resonance imaging:New perspectives for osteoporotic fracture risk assessment显示文摘Osteoporosis represents one major health condition for our growing elderly population. It accounts for severe morbidity and increased mortality in postmenopausal women and it is becoming an emerging health concern even in aging men. Screening of the population at risk for bone degeneration and treatment assessment of osteoporotic patients to prevent bone fragility fractures represent useful tools to improve quality of life in the elderly and to lighten the related socio-economic impact. Bone mineral density(BMD) estimate by means of dual-energy X-ray absorptiometry is normally used in clinical practice for osteoporosis diagnosis. Nevertheless, BMD alone does not represent a good predictor of fracture risk. From a clinical point of view, bone microarchitecture seems to be an intriguing aspect to characterize bone alteration patterns in aging and pathology. The widening into clinical practice of medical imaging techniques and the impressive advances in information technologies together with enhanced capacity of power calculation have promoted proliferation of new methods to assess changes of trabecular bone architecture(TBA) during aging and osteoporosis. Magnetic resonance imaging(MRI) has recently arisen as a useful tool to measure bone structure in vivo. In particular, high-resolution MRI techniques have introduced new perspectives for TBA characterization by non-invasive non-ionizing methods. However, texture analysis methods have not found favor with clinicians as they produce quite a few parameters whose interpretation is difficult. The introduction in biomedical field of paradigms, such as theory of complexity, chaos, and fractals, suggests new approaches and provides innovative tools to develop computerized methods that, by producing a limited number of parameters sensitive to pathology onset and progression, would speed up their application into clinical practice. Complexity of living beings and fractality of several physio-anatomic structures suggest fractal analysis as a promising approach to quantify morphofunctional changes in both aging and pathology. In this particular context, fractal lacunarity seems to be the proper tool to characterize TBA texture as it is able to describe both discontinuity of bone network and sizes of bone marrow spaces, whose changes are an index of bone fracture risk. In this paper, an original method of MRI texture analysis, based on TBA fractal lacunarity is described and discussed in the light of new perspectives for early diagnosis of osteoporotic fractures. | Annamaria Zaia | 2015 | World Journal of Orthopedics2015，6，2： | 3 |
| 2 | Isolation and recognition of dermatophytes on a new medium (DTM)显示文摘 | Taplin D Zaias N Rebell G | 1969 | Arch Dermatol1969，99，2： | 1 |
| 3 | Treatment of chronic moccasin type tinea pedis with Terbinafine 显示文摘 | Savin RC Zaias N | 1990 | Journal of American Academy of Dermatology1990，23，： | 1 |
| 4 | Autosomal dominant pattern of distsubungual onychomycosis caused by Trichophyton rubrum显示文摘 | Tosti A Rebell G | 1996 | J Am Acad Dermatol1996，34，21： | 1 |
| 5 | The longitudeinal nail biopsy 显示文摘 | Zaias N | 1967 | Jinvest Dermatol1967，4，4： | 1 |
| 6 | Autosomal dominant pattern of distal subungual onychomycosis caused by Trichophyton rubrum 显示文摘 | Zaias N Tosti A Rebell G | 1996 | J Am Acad Dermatol1996，34，21： | 1 |
| 7 | Comparison of traditional and PCR methods during screening for and confirmation of Aspiculuris tetraptera in a mouse facility显示文摘 | DOLE VS ZAIAS J KYRICOPOULOS-CLEASBY DM | 2011 | J Am Assoc Lab Anim Sci2011，50，6： | 1 |
| 8 | Considerations for the clinical applicationof chimeric antigen receptor T cells: observations froma recombinant DNA Advisory Committee Symposiumheld June 15,2010 显示文摘 | Ertl H C Zaia J? Rosenberg S A June C H Dotti G Kahn J | 2011 | Cancer Res2011，71，： | 1 |
| 9 | Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein显示文摘 | da Cruz e Silva EF da Cruz e Silva OA Zaia CT | 1995 | Mol Med1995，1，： | 1 |
| 10 | Use of rice straw as biosorbent for removal of Cu(Ⅱ), Zn(Ⅱ), Cd(Ⅱ) and Hg(Ⅱ) ions in industrial effluents显示文摘 | Rocha CG Zaia DAM Alfaya RVD | 2009 | Journal of hazardous materials2009，166，1： | 1 |
| 11 | Investigation of the marginal adaptation of root - end filling materials in root - end cavities prepared with ultrasonic tips显示文摘 | Gondim E Zaia AA Gomes BP | 2003 | Int Endod J2003，36，7： | 1 |
| 12 | Considerations for the clini- cal application of chimeric antigen receptor T cells: Observations from a recombinant DNA advisory committee symposium held June 15, 2010 显示文摘 | Ertl HC Zaia J Rosenberg SA | 2011 | CancerRes2011，71，9： | 1 |
| 13 | Use of rice straw as biosorbent for removal of Cu(Ⅱ),Zn(Ⅱ),Cd(Ⅱ) and Hg(Ⅱ)ion in industrial effluents显示文摘 | ROCHA C G ZAIA D A M ALFAYA R V D S | | 0，，： | 1 |
| 14 | Prevention and management of CMV-relatad Problems after hematopoietic stem cell transplantion显示文摘 | ZAIA J A | 2002 | Bone Morrow Fransplant2002，29，： | 1 |
| 15 | The SH-3 and SH-4 Antibodies Recognize Distinct Epitopes on CD73 from Human Mesenchymal Stem Cells显示文摘 | Frank Barry Raymond Boynton Mary Murphy Joseph Zaia | 2001 | Biochemical and Biophysical Research Communications2001，，2： | 1 |
| 16 | Use of rice straw as biosorbent for removal of Cu(II), Zn(II), Cd(II) and Hg (II) ions in industrial effluents显示文摘 | Rocha C G Zaia D A M Alfaya R V S | 2009 | Journal of Hazardous Materials2009，166，： | 1 |
| 17 | Microscopic cleanliness evaluation of the apical root canal after using calcium hydroxide mixed with chlorhexidine, propylene glycol, or antibiotic paste 显示文摘 | Da Silva JM Andrade Junior CV Zaia AA | 2011 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2011，111，2： | 1 |
| 18 | Chlorhexidine in endodontie显示文摘 | Gomes BPFA Vianna ME Zaia AA | 2013 | Braz Dent J2013，24，： | 1 |
| 19 | Mass spectrometry of oligosaccharides 显示文摘 | Joseph Zaia | 2004 | Mass Spectrometry Reviews2004，23，： | 1 |
| 20 | Mass spectrometry of oligosaccharides 显示文摘 | ZAIA J | 2004 | Mass Spectrometry Reviews2004，23，3： | 1 |
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