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| 1 | 点阵激光联合富血小板血浆治疗痤疮瘢痕显示文摘背景富血小板血浆(PRP)因其富含大量的生长因子,已经被应用于增强激光治疗痤疮瘢痕的临床疗效,但是其具体作用机制尚不得而知。目的 本研究旨在探讨PRP联合点阵激光治疗痤疮瘢痕背后的分子机制。方法 受试者的痤疮瘢痕程度从轻度到中度,采用自身对照的方法,受试者在使用点阵CO_2激光治疗后,一侧面部使用PRP辅助治疗,另一侧不使用PRP。设立患者皮肤活检状态的基线,在治疗后第1天、第3天、第7天和第28天分别获得皮肤活检标本并进行检测,研究激光联合PRP后皮肤相关变化的分子层面因素。结果 激光联合PRP治疗痤疮瘢痕的临床疗效更佳,降低了红斑、肿胀和渗出等不良反应的严重程度。 | Min S Yoon JY Park SY | 2018 | 中国医疗美容2018，8，1： | 12 |
| 2 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 3 | The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase显示文摘Suicide genes have recently emerged as an attractive alternative therapy for the treatment of various types of intractable cancers.The efficacy of suicide gene therapy relies on efficient gene delivery to target tissues and the localized concentration of final geneproducts. | Chang DY Yoo SW Hong Y Kim S Kim SJ Yoon SH Cho KG Paek SH Lee YD Kim SS Suh-Kim H | 2010 | 中国神经肿瘤杂志2010，8，2： | 3 |
| 4 | Low-temperature sintering and microwave dielectric properties of Ca(Li1/3 Nb2/3)O3-δ ceramics显示文摘 | Liu Peng Kim E S Yoon K H | 2001 | Jpn Journal Application Physics2001，40，： | 2 |
| 5 | Microwave diele- ctric properties of complex perovskit Ba(Mg1/3Ta2/3)O3显示文摘 | KIM E S YOON K H | 1992 | Ferroelectrics1992，133，： | 2 |
| 6 | Continuous HMM applied to quantization of on - line Korean character spaces显示文摘 | JUNG K C YOON S M KIM H J | 2000 | Pattern Recognition Letters2000，21，： | 2 |
| 7 | A problem reduction and decomposition approach for scheduling for a flowshop of batch processing machines 显示文摘 | Sung C S Kim Y H Yoon S H | 2000 | European Journal of Operational Research2000，121，： | 2 |
| 8 | Increased b-carotene production in recombinant Escherichia eoli harboring an engineered isoprenoid precursor pathway with mevalonate addition 显示文摘 | Yoon S H | 2007 | Biotechnol Prog2007，23，： | 1 |
| 9 | Single-nucleotide polymorphisms of the interleukin-18 gene promoter region in rheumatoid arthritis patients: protective effect of AA genotype 显示文摘 | Sivalingam S P Yoon K H Koh D R | 2003 | Tissue Antigens2003，62，6： | 1 |
| 10 | Nitric oxide inhibits the shedding of the glycosylphosphatidylinositol-anchored dipeptidase from porcine renal proximal tubules 显示文摘 | Park S W Yoon H J Lee H B | 2002 | Biochem J2002，364，1： | 1 |
| 11 | Modifying the soil to affect the seed:role of stromal-derived matrix metalloproteinases in cancer progression显示文摘 | Jodele S Blavier L Yoon JM | 2006 | Cancer Metastasis Rev2006，25，1： | 1 |
| 12 | Sequence-based screening for putative polyketide synthase gene-harboring clones from a soil metagenome library 显示文摘 | JI S C KIM D YOON J H | 2006 | J Microbiol Biotechnol2006，16，： | 1 |
| 13 | Preparation of spherical activated carbon with high electric double-layer capacitance 显示文摘 | Lee S I Mitani S Yoon S H | 2004 | Carbon2004，42，11： | 1 |
| 14 | Dispersion polymerization of acrylamide with quaternary ammonium cationic comonomer in aqueous solution显示文摘 | Song B K Cho M S Yoon K J | 2003 | J Appl Polym Sci2003，87，： | 1 |
| 15 | Live births after vitrification of oocytes in a stimulated in vitro fertilization-embryo transfer program显示文摘 | Kim T J Park S E | 2003 | Fertil Steril2003，79，： | 1 |
| 16 | Anaerobic and aerobic degradation of pyridine by a newly isolated denitrifying bacterium 显示文摘 | Rhee S K Lee G M Yoon J H | 1997 | Appl Environ Microb1997，63，7： | 1 |
| 17 | Fate of endocrinedisruptor, pharmaceutical, and personal care product chemicals during simulated drinking water treatment processes 显示文摘 | Westerhoff P Yoon Y Snyder S | 2005 | Environ Sci Technol2005，39，： | 1 |
| 18 | 显示文摘 | Park S H Yoon C S Kang S G | 2004 | Electrochimica Acta2004，49，4： | 1 |
| 19 | Morphology and thermal properties of poly (L-lactide)/poly (butylene succinate-co-butylene adipate) compounded with twice functionalized clay显示文摘 | CHEN G X YOON J S | 2005 | Journal of polymer science part B-polymer physics2005，43，5： | 1 |
| 20 | Measurement of Particle Velocity and Characterization of Deposition in Aluminum Alloy Kinetic Spraying Process 显示文摘 | Wu J Fang H Yoon S | 2005 | Applied Surface Scince2005，252，： | 1 |
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