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| 1 | The cartilage matrisome in adolescent idiopathic scoliosis显示文摘The human spinal column is a dynamic,segmented,bony,and cartilaginous structure that protects the neurologic system and simultaneously provides balance and flexibility.Children with developmental disorders that affect the patterning or shape of the spine can be at risk of neurologic and other physiologic dysfunctions.The most common developmental disorder of the spine is scoliosis,a lateral deformity in the shape of the spinal column.Scoliosis may be part of the clinical spectrum that is observed in many developmental disorders,but typically presents as an isolated symptom in otherwise healthy adolescent children.Adolescent idiopathic scoliosis(AIS)has defied understanding in part due to its genetic complexity.Breakthroughs have come from recent genome-wide association studies(GWAS)and next generation sequencing(NGS)of human AIS cohorts,as well as investigations of animal models.These studies have identified genetic associations with determinants of cartilage biogenesis and development of the intervertebral disc(IVD).Current evidence suggests that a fraction of AIS cases may arise from variation in factors involved in the structural integrity and homeostasis of the cartilaginous extracellular matrix(ECM).Here,we review the development of the spine and spinal cartilages,the composition of the cartilage ECM,the so-called'matrisome'and its functions,and the players involved in the genetic architecture of AIS.We also propose a molecular model by which the cartilage matrisome of the IVD contributes to AIS susceptibility. | Carol AWise Diane Sepich Aki Ushiki Anas MKhanshour Yared HKidane Nadja Makki Christina AGurnett Ryan SGray Jonathan JRios Nadav Ahituv Lila Solnica-Krezel | 2020 | Bone Research2020，8，1： | 5 |
| 2 | Hierarchical approach for fatigue cracking performance evaluation in asphalt pavements显示文摘 | Ibrahim ONIFADE Yared DINEGDAE Bjorn BIRGISSON | 2017 | Frontiers of Structural and Civil Engineering2017，11，3： | 4 |
| 3 | Change in estimated cerebral perfusion pressure after treatment with nimodipine or magnesium sulfate in patients with preeclampsia显示文摘 | Belfort MA Saade GR Yared M | 1999 | Am J Obstet Gynecol1999，181，： | 1 |
| 4 | Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components显示文摘 | Miyakawa T Yared E Pak JH | 2001 | Hippoeampus2001，11，6： | 1 |
| 5 | Optimal generator maintenance scheduling using a modified discrete PSO显示文摘 | YARE Y VENYAGAMOORTHY G K ALIYU U O | 2008 | IET Generation Transmission and Distribution2008，2，6： | 1 |
| 6 | ARF After open heart surgery:Influence of gender and race显示文摘 | Thakar CV Liangos O Yared JP | 2003 | Am J Kidney Dis2003，41，4： | 1 |
| 7 | ARF after open-heart surgery: influence of gender and race 显示文摘 | THAKAR C V LIANGOS O YARED J P | 2003 | Am J Kidney Dis2003，41，4： | 1 |
| 8 | Failure of Profile instruments used with high and low torque motors 显示文摘 | Yare GM Bou Dagher FE Machtou P | 2001 | Int Endod J2001，34，： | 1 |
| 9 | Failure of p rofile Ni-Ti instruments used by an inexperienced operator under access limitations显示文摘 | Yared GM Kulkarni GK | 2002 | Int Endod J2002，35，6： | 1 |
| 10 | Failure of Profile instruments used with high and low torque motors 显示文摘 | Yare GM Bou Dagher FE Machtou P | 2001 | Int Endod J2001，34，： | 1 |
| 11 | Cytokine-mediated apoptosis and inhibition of virus production and anchorage independent growth of viral transfected hepatoblastoma cells显示文摘 | Yared G | | 0，，： | 1 |
| 12 | Influence of rotational speed, torque and operator' s proficiency on profile failtures显示文摘 | Yared GM Bou Dagher FE Kulkarni K | 2003 | Oral Surg Oral Med Oral Pathol2003，96，2： | 1 |
| 13 | Influence of rotational speed, torque and operator's proficiency on Profile failures 显示文摘 | Yared GM Dagher FE Machton P | 2001 | Int Endod J2001，34，： | 1 |
| 14 | Periodontal status of mandibular central incisors after orthodon- tic proclination in adults显示文摘 | Yared KF Zenobio EG Pacheco W | 2006 | Am J Orthod Dentofacial Orthop2006，130，1： | 1 |
| 15 | Nonsteroidal anti-inflammatory drugs and acute renal failure in elderly persons 显示文摘 | Griffin MR Yared A Ray WA | 2000 | Am J Epidemiol2000，151，5： | 1 |
| 16 | Diagnosis and treatment 显示文摘 | Yared Z Chiasson JL Ketoacidosis and the hyperosmolar hyperglycemic state in adult diabetic patients | 2003 | Minerva Med2003，94，6： | 1 |
| 17 | Canal preparation using only one Ni-Ti rotary instrument : preliminary observations 显示文摘 | Yared G | 2008 | Int Endod J2008，41，4： | 1 |
| 18 | Influence of rotational speed, torque and operator's proficiency on profile failure 显示文摘 | Yared GM Bou Dagher FE Kulkami K | 2003 | Oral Surg Oral Med Oral Pathol2003，96，2： | 1 |
| 19 | Vitamin D insulin sensitivity and adiponetin in a young Middle- Eastern population 显示文摘 | Gannage -yared MH Chedid R Khalife S | 2009 | Eur J Endocrinol2009，160，： | 1 |
| 20 | Impact of family hypertension history on exercise-induced cardiac remodeling 显示文摘 | Aaron L Baggish Rory B Weiner Kibar Yared | 2009 | The American Journal of Cardiology2009，104，1： | 1 |
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