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| 1 | An environmentally benign multi-component reaction:Highly regioselective synthesis of functionalized 2-(diarylphosphoryl)-1,2-dihydro-pyridine derivatives显示文摘A novel protocol was developed for the construction of highly functionalized 2-(diarylphosphoryl)-1,2-dihydropyridine derivatives(DAPDHPs)from 3-formylchromones(1),heterocyclic ketene aminals(HKAs,2),and phosphine oxides(R_(2)P(O)H,3)via a novel,one-pot cascade reaction.Optimization of the reaction conditions determined that refluxing the mixture of the 3-formylchromones,HKAs,and various R_(2)P(O)H in propylene carbonate(PC)in the presence of triethylamine as a base facilitated the highest yields of the DAPDHP products.This cascade reaction,which involved the cleavage of one C-O bond in the 3-formylchromone substrates and the formation of three new bonds(one C-C,one C-N,and one C-P bond),enabled the synthesis of a small library of DAPDHP products.The dearomatized DAPDHP products were formed by the regioselective nucleophilic addition of the R_(2)P(O)H reagents to the intermediate pyridinium salts 8.This approach has several advantages such as the use of an environmentally-friendly solvent,simple and practical operation(with filtration and washing without column chromatography separation),good yields,and a product with potential biological activity. | Kun Li Ying Lv Zihan Lu Xinghan Yun Shengjiao Yan | 2022 | Green Synthesis and Catalysis2022，3，1： | 0 |
| 2 | Asymmetric Synthesis of All Four Isomers of an Unusual Heterocycle-Containing Amino Acid : 2-Amino-3-furan-2-yl-pentanoic Acid显示文摘新奇分叉的不平常的氨基酸的所有四异构体与高 stereoselectivity 被设计并且综合(>90% de ) 并且在由 4 的使用(R/S ) 的 33%44% 全面收益是的 -5,5-dimethyl-4-phenyl-oxazolidin-2-one 经由不对称的 1,4-Michael 增加,直接或间接的 azidation,水解作用和加氢辅助的 chiral 反应。 | Nie,Lei Yang,Rui Zhang,Conghai Yin,Haichuan Yan,Shengjiao Lin,Jun | 2012 | Chinese Journal of Chemistry2012，30，2： | 0 |
| 3 | Highly selective synthesis of functionalized morphan derivatives through a multi-component cascade reaction of 3-formylchromones, 2-naphthols, and enaminones显示文摘A novel protocol for the preparation of highly functionalized 2-azabicyclo[3.3.1]nonane(morphan)derivatives via a multicomponent cascade reaction,involving 3-formylchromones,2-naphthols,and enaminones in the ionic liquid[BMIM]PF6 as the solvent and promoted by 1,8-diazabicyclo[5.4.0]undec-7-ene(DBU),was developed,which involved the cleavage of one C–O bond and formation of four bonds(1 C–O,1 C–N,and 2 C–C bonds).As a result,a series of morphan derivatives were produced through a cascade reaction,including a sequence of 1,2-addition,enol-keto tautomerization,Michael addition,dehydration,another Michael addition,imine-enamine tautomerization,and N-alkylation reactions,which were accompanied by a ring-opening reaction.This protocol was suitable for combinatorial and parallel syntheses of natural product-like morphan compounds in a one-pot reaction rather than through tedious multi-step reactions. | Xinling Cao Yinggang Duan Kaihong Lv Zihan Lu Yihua Chen Shengjiao Yan | 2023 | Green Synthesis and Catalysis2023，4，4： | 0 |
| 4 | Multicomponent cascade reaction of 3-formylchromones:Highly regioselective synthesis of functionalized pyridin-2(1H)-ones显示文摘A novel protocol was developed for the construction of highly functionalized pyridin-2(1H)-ones from 3-formylchromones,ethyl 2-(pyridin-2-yl)acetate derivatives and amines via a complex multicomponent cascade reaction involving targeted duplicated ring-opening and duplicated cyclization reactions which form skeleton-reorganized target compounds.A series of pyridin-2(1H)-ones were produced by this reaction accompanied by the formation of three bonds(one C–N and two C–C bonds)and the cleavage of one bond in one step.This protocol can be used in combinatorial and parallel syntheses of various pyridin-2(1H)-ones with potent biological activity.The advantages of this approach include simple and practical operation(multicomponent one-pot),high yields(up to 91%),and products with potential biological activity. | Xinghan Yun Li Chen Ying Lv Zihan Lu Kun Huang Shengjiao Yan | 2023 | Green Synthesis and Catalysis2023，4，3： | 0 |
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