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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 3 | 中草药对断奶仔猪中性粒细胞免疫活性和小肠形态学的影响显示文摘试验旨在评估由人参、薯蓣、白术、甘草、红枣和桔梗组成的中草药(CMH)对断奶仔猪生产性能、肠道形态学和免疫活性的影响。将240头断奶仔猪随机分为4个日粮处理组:负对照组(基础日粮),CMH0.1%、CMH0.3%、抗生素0.114%(金霉素钙复合物、磺胺噻唑、青霉素普鲁卡因G)添加组,试验期28d。结果表明,试验期前14d,两个CMH添加组比对照组(CT组)有较佳的增重和饲料增重比。与其他组比较,在试验前10d,CMH0.3%组的腹泻评分显著下降。与对照组比较,CMH添加组有较高的绒毛高度,回肠食糜乳酸菌计数增加,大肠菌群数下降。在试验第7天,CMH添加组的多形核白细胞(PMNs)活性,包括突发性呼吸和沙门氏菌杀灭能力显著提高。添加CMH和抗生素可提高断奶仔猪日粮干物质、粗蛋白质和总能的养分消化率。结果表明,日粮添加CMH可改善肠道形态学和PMNs的免疫活性,因而提高断奶仔猪的养分消化率,降低腹泻频率。 | Huang C W Lee T T Shih Y C Yu B 张树金 | 2012 | 饲料博览2012，，9： | 2 |
| 4 | Durable Asphalt Pavements Are Self Healing显示文摘The traffic volume and the number of heavy vehicles are growing continuously. Considering the continuous traffic flow and the limited time available for road maintenance,it is very important to design a durable pavement system. Asphalt pavements with a healing capability are believed to be very useful since they can extend the pavement service life thanks to rest periods and hot summers. In order to design durable asphalt pavements,research in understanding and upgrading the self-healing capability of bituminous materials in time is of major importance. The self healing capability of bituminous mastic was evaluated in this research with a direct tension healing test. In the test program,different healing times,crack status and modifications were applied. The results indicate that elastic recovery and flow capacity are important factors for the self healing capability of bituminous materials at different crack phases as simulated with the direct tension test. | QIU J VAN DE VEN M F C WU S P YU J Y MOLENAAR A A A | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 5 | Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six - 1 as key metastatic regulators 显示文摘 | Yu Y Khan J Khanna C | 2004 | Nat Med2004，10，2： | 1 |
| 6 | Antiprotozal activities of Centipeda minima显示文摘 | Yu H W WRIGHT C W CAI Y | 1994 | Phytoherapy Research1994，8，： | 1 |
| 7 | A novel ultraviolet irradiation photoreduetion technique for the preparation of single-crystal Ag nanorods and Ag dendrites 显示文摘 | Zhou Y Yu S H Wang C Y | 1999 | Advanced Materials1999，11，10： | 1 |
| 8 | Fermi pinninginduced thermal instability of metal-gate work function 显示文摘 | YU H Y REN C YEO Y C | 2004 | IEEE Elec Dev Lett2004，25，5： | 1 |
| 9 | Uniform Metal Nanotube Arrays by Multistep Template Replication and Electrodeposition显示文摘 | Yu Y X Wang R M | 2004 | Adv Mater2004，16，17： | 1 |
| 10 | The prevalence of iron deficiency anemia and its clinical implications in patients with colorectal carcinoma显示文摘 | Ho C H Yu Y B Wu P H | 2008 | J Chin Med Assoc2008，71，3： | 1 |
| 11 | Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer显示文摘 | Mok T S Wu Y L Yu C J | 2009 | J ClinOneol2009，27，30： | 1 |
| 12 | Polyamide thin film composite membrane prepared from m-phenylenediamine and m-phenylenediamine-5-sulfonic acid 显示文摘 | Zhou Y Yu S C Liu M H | 2006 | Journal of Membrane Science2006，270，12： | 1 |
| 13 | Joint optimization of relay strategies and resource allocation in cooperative cellular networks显示文摘 | NG T C Y YU Wei | 2007 | IEEE Journal on Selected Areas in Communications2007，25，2： | 1 |
| 14 | Tin nanoparticles encapsulated in porous multichannel carbon microtubes: Preparation by single -zozzle electrospinning and application as anode material for high-performance Li-based batteries 显示文摘 | Yu Y Gu L Zhu C et ol | 2009 | Journal of the American Chemical Society2009，131，15： | 1 |
| 15 | The relationship between coronary ar tery disease and abnormal glucose regulation in China: the China Heart Survey显示文摘 | Hu D Y Pan C Y Yu J M | 2006 | Eur Heart J2006，27，21： | 1 |
| 16 | A 3-D transformation to improve the legibility of license plate numbers显示文摘 | Wen C Y Yu C C | 2002 | Journal of Forensic Sciences2002，47，3： | 1 |
| 17 | Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis显示文摘 | Suarez Y Fernandez Hernando C Yu J | 2008 | Proc Natl Acad Sci USA2008，105，14： | 1 |
| 18 | Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle显示文摘 | Yu C Chen Y Cline GW | 2002 | J Biol Chem2002，277，50： | 1 |
| 19 | Research on the additional stress and deformation in the soil of compo-site pile foundation under vertically uniform loads显示文摘 | Yu C Za J M Liu S Y | 2005 | Advances in Deep Foundations(GSP132)2005，，157： | 1 |
| 20 | Ultraviolet-Emitting ZnO Nanowires Synthesized by a Physical Vapor Deposition Approach显示文摘 | Kong Y C Yu D P Zhang B | 2001 | Appl Phys Lett2001，78，： | 1 |
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