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| 1 | Probiotic modulation of dendritic cells co-cultured with intestinal epithelial cells显示文摘AIM:To investigate cytokine production and cell surface phenotypes of dendritic cells (DC) in the presence of epithelial cells stimulated by probiotics.METHODS:Mouse DC were cultured alone or together with mouse epithelial cell monolayers in normal or inverted systems and were stimulated with heat-killed probiotic bacteria,Bifidobacterium lactis AD011 (BL),Bifidobacterium bifidum BGN4 (BB),Lactobacillus casei IBS041 (LC),and Lactobacillus acidophilus AD031 (LA),for 12 h.Cytokine levels in the culture supernatants were determined by enzyme-linked immunosorbent assay and phenotypic analysis of DC was investigated by flow cytometry.RESULTS:BB and LC in single-cultured DC increased the expression of I-Ad,CD86 and CD40 (I-Ad,18.51 vs 30.88,46.11;CD86,62.74 vs 92.7,104.12;CD40,0.67 vs 6.39,3.37,P < 0.05).All of the experimental probiot-ics increased the production of inflammatory cytokines,interleukin (IL)-6 and tumor necrosis factor (TNF)-α.However,in the normal co-culture systems,LC and LA decreased the expression of I-A d (39.46 vs 30.32,33.26,P < 0.05),and none of the experimental probiotics increased the levels of IL-6 or TNF-α.In the inverted coculture systems,LC decreased the expression of CD40 (1.36 vs-2.27,P < 0.05),and all of the experimental probiotics decreased the levels of IL-6.In addition,BL increased the production of IL-10 (103.8 vs 166.0,P < 0.05) and LC and LA increased transforming growth factor-β secretion (235.9 vs 618.9,607.6,P < 0.05).CONCLUSION:These results suggest that specific probiotic strains exert differential immune modulation mediated by the interaction of dendritic cells and epithelial cells in the homeostasis of gastrointestinal tract. | Ji Yeun Kim Myeong Soo Park Geun Eog Ji | 2012 | World Journal of Gastroenterology2012，18，12： | 10 |
| 2 | Clinical course of subepithelial lesions detected on upper gastrointestinal endoscopy显示文摘AIM:To evaluate the natural history of subepithelial lesions.METHODS:We reviewed the medical records of 104 159 patients who underwent upper gastrointestinal endoscopy at the Center for Health Promotion of Samsung Medical Center between 1996 and 2003.Subepithelial lesions were detected in 795 patients(0.76%);252 patients were followed using upper gastrointestinal endoscopy for 82.5 ± 29.2 mo(range,12-160 mo;median,84 mo;1st quartile,60 mo;3rd quartile,105 mo).The median interval of follow-up endoscopy was 12 mo(range,6-105 mo;1st quartile,12 mo;3rd quartile,24 mo).RESULTS:The mean patient age was 53 years(range,22-80 years),and the male-to-female ratio was 2.36:1(177/75).The lesion size at initial measurement averaged 8.9 mm(range,2-25 mm;median,8 mm;1st quartile,5 mm;3rd quartile,10 mm).Of the 252 lesions,244(96.8%) were unchanged and 8(3.2%) were significantly increased in size(from 12.9 ± 6.0 to 21.2 ± 12.2 mm) after a mean interval of 59.1 ± 27.5 mo(range,12-86 mo).Surgical resection of lesions was performed when the lesions were ≥ 3 cm in diameter.Two lesions were diagnosed as gastrointestinal stromal tumors with an intermediate or high risk of malignancy and one lesion was classified as a schwannoma.CONCLUSION:Most small subepithelial lesions do not change as shown by endoscopic examination,and regular follow-up with endoscopy may be considered in small,subepithelial lesions,especially lesions < 1 cm in size. | Yeun Jung Lim Hee Jung Son Jong-Soo Lee Young Hye Byun Hyun Joo Suh Pool Lyul Rhee Jae J Kim Jong Chul Rhee | 2010 | World Journal of Gastroenterology2010，16，4： | 6 |
| 3 | Simultaneous laparoscopic multi-organ resection combined with colorectal cancer:Comparison with non-combined surgery显示文摘AIM: To access the short-term outcomes of simultaneous laparoscopic surgery combined with resection for synchronous lesions in patients with colorectal cancer. METHODS: Between March 1996 and April 2010 prospectively collected data were reviewed from 93 consecutive patients who had colorectal cancer and underwent simultaneous multiple organ resection (combined group) and 1090 patients who underwent conventional laparoscopic right hemicolectomy or laparoscopic low/ anterior resection for colorectal cancer (non-combined group). In the combined group, there were nine gastric resections, three nephrectomies, nine adrenalectomies, 56 cholecystectomies, and 21 gynecologic resections. In addition, f ive patients underwent simultaneous laparoscopic resection for three organs. The patient demographics, intra-operative outcomes, surgical morbidity, and short-term outcomes were compared between thetwo groups (the combined and non-combined groups). RESULTS: There were no signifi cant differences in the clinicopathological variables between the two groups. The operating time was signifi cantly longer in the combined group than in the non-combined group, regardless of tumor location (laparoscopic right hemicolectomy and laparoscopic low/anterior resection groups; P = 0.048 and P < 0.001, respectively). The other intraoperative outcomes, such as the complications and open conversion rate, were similar in both groups. The rate of post-operative morbidity in the combined group was similar to the non-combined group (combined vs non-combined, 15.1% vs 13.5%, P = 0.667). Oncological safety for the colon and synchronous lesions were obtained in the combined group. CONCLUSION: Simultaneous laparoscopic multiple organ resection combined with colorectal cancer is a safe and feasible option in selected patients. | Hye Jin Kim Gyu-Seog Choi Jun Seok Park Soo Yeun Park Soo Han Jun | 2012 | World Journal of Gastroenterology2012，18，8： | 6 |
| 4 | Short-term clinical outcome of robot-assisted intersphincteric resection for low rectal cancer: a retrospective comparison with conventional laparoscopy显示文摘 | Soo Yeun Park Gyu-Seog Choi Jun Seok Park Hye Jin Kim Jong-Pil Ryuk | 2013 | Surgical Endoscopy2013，，1： | 4 |
| 5 | Co-infection of Pneumocystis jirovecii and Aspergillus in a patient with idiopathic thrombocytopenic purpura显示文摘PCP and IA co-infection in HIV patients has been reported.[3] However,only nine cases co-infected with PCP and IA in non-HIV patients are reported.[4-6] Herein,we report a fatal case of PCP and IA co-infection in a patient undergoing high-dose corticosteroid therapy for idiopathic thrombocytopenic purpura. | Dong-Hwa Lee Jun Yeun Cho Sun-Hyung Kim Hee-Sung Kim Ok-Jun Lee Yoon Mi Shin | 2019 | Chinese Medical Journal2019，，15： | 3 |
| 6 | C-reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients显示文摘 | Jane Y. Yeun Richard A. Levine Viput Mantadilok George A. Kaysen | 2000 | American Journal of Kidney Diseases2000，，： | 3 |
| 7 | Review of the High-Temperature Oxidation of Iron and Carbon Steels in Air or Oxygen显示文摘 | R.Y. Chen W.Y.D. Yeun | 2003 | Oxidation of Metals (-)2003，，5： | 2 |
| 8 | Acute phase response predicts erythropoietin resistance in hemodialysis and peritoneal dialysis patients显示文摘 | Gunnell J Yeun J Y Depner T A | 1999 | AmJ Kidney Dis1999，33，1： | 1 |
| 9 | Acute-phase response predicts erythropoietin resistance in hemodialysis and peritoneal dialysis patients显示文摘 | Gunnell J Yeun JY Depner TA | 1999 | Am J Kidney Dis1999，33，： | 1 |
| 10 | Fixing a problem in the helsinki protocol 显示文摘 | MITCHELL C J YEUN C Y | 1998 | Operating Systems Review1998，，32： | 1 |
| 11 | A cute-phase response predicts erythropoitin resistance in HD and PD patients显示文摘 | Gumnell J Yeun JY depner TA | | 0，，： | 1 |
| 12 | Managing approximation models in multi-objective optimization显示文摘 | Yang B S Yeun Y S Ruy W S | 2002 | Structural and Multidisciplinary Optimization2002，24，2： | 1 |
| 13 | Moldeling directional solidification of a dendritic alloy 显示文摘 | YEUN K S and POIR1ER D R | 1988 | Cast Metals1988，1，3： | 1 |
| 14 | Development of a NuF sing Professional Values Scale显示文摘 | Yeun E J Kwon Y M Ahn O H | 2005 | Taehan Kanho Hakhoe Chi2005，35，6： | 1 |
| 15 | C-reaction proteinpredicts all causand cardiovascular mortality in hemodialysis patients显示文摘 | Yeun JY Levine RA Mantadflok V | 2012 | Am J Kidney Dis2012，35，3： | 1 |
| 16 | Attitudes toward stress and coping among primary caregivers of patients undergoing hemodialysis : A Q- methodology study显示文摘 | Yeun E J Bang HY Kim E J | 2016 | Hemodial int2016，20，3： | 1 |
| 17 | Creactiveprotein predicts all cause and cardiovascular mortality in hemodialysis patients 显示文摘 | Yeun J Y Levine R A Mantadilok N | 2000 | Am J Kidney Dis2000，35，3： | 1 |
| 18 | C-reactive protein predicts all cause and cardiovascular mortality in hemodialysis patients显示文摘 | Yeun J Y Levine R A Mantadilok V | 2000 | Am J Kidney Dis2000，35，3： | 1 |
| 19 | C-reactive protein predicts all-cause and cardiovascularmortality in hemodialysis patients 显示文摘 | YEUN J Y LEVINE R A MANTADILOK N | 2000 | Am J Kidney Dis2000，35，46： | 1 |
| 20 | C--reative protein prediees all--cause and cardiovascular mortality in hemodialysis patients显示文摘 | Yeun JY Levinr RA Mantadilok V et at | 2000 | Am J Kidney Dis2000，35，： | 1 |
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