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| 1 | Role of prophylactic antibiotics in cirrhotic patients with variceal bleeding显示文摘Bacterial infections are common in cirrhotic patients with acute variceal bleeding,occurring in 20%within48 h.Outcomes including early rebleeding and failure to control bleeding are strongly associated with bacterial infection.However,mortality from variceal bleeding is largely determined by the severity of liver disease.Besides a higher Child-Pugh score,patients with hepatocellular carcinoma are particularly susceptible to infections.Despite several hypotheses that include increased use of instruments,greater risk of aspiration pneumonia and higher bacterial translocation,it remains debatable whether variceal bleeding results in infection or vice versa but studies suggest that antibiotic prophylaxis prior to endoscopy and up to 8 h is useful in reducing bacteremia and spontaneous bacterial peritonitis.Aerobic gram negative bacilli of enteric origin are most commonly isolated from cultures,but more recently,gram positives and quinolone-resistant organisms are increasingly seen,even though their clinical significance is unclear.Fluoroquinolones(including ciprofloxacin and norfloxacin)used for short term(7 d)have the most robust evidence and are recommended in most expert guidelines.Short term intravenous cephalosporin(especially ceftriaxone),given in a hospital setting with prevalent quinolone-resistant organisms,has been shown in studies to be beneficial,particularly in high risk patients with advanced cirrhosis. | Yeong Yeh Lee Hoi-Poh Tee Sanjiv Mahadeva | 2014 | World Journal of Gastroenterology2014，20，7： | 31 |
| 2 | 基于扎根理论的高校“水课”教育改革研究显示文摘高校中普遍存在的'水课'现象引起了社会各界的广泛关注。'水课'的存在导致学生无法从教学内容中有效地学到专业知识,浪费他们的时间与精力,同时也意味着学校教学资源的浪费。尽管'水课'现象已经引起了人们的关注,但是目前教育领域的学者却极少关注这种现象。文章使用扎根理论的方法来研究'水课'现象,试图探索出'水课'存在的导因,并据此为我国的高校教育改革提出有科学依据的建议。研究发现,大学生一般会将具有重复性内容的课程、任课教师授课不专业、考核方式过于简单的课程视为'水课'。鉴于此,在深化教育改革过程中,需要在树立课程考核方式,注重提升教师专业水平,重视学生意见等方面深挖完善举措。 | Jhony Choon Yeong Ng 陈红雪 宋凯文 谭清美 夏后学 | 2017 | 高教学刊2017，3，22： | 27 |
| 3 | 利他主义与利他行为:三个年龄群体的扎根理论研究显示文摘已有文献出现了冠以利他行为之名的助人行为研究以及假定利他主义和利他行为的可替换性的混乱局面。鉴于此,采用经典扎根理论的方法,针对高中生、大学生、职场人士这三个年龄群体,在中国的情境下,重新探讨利他主义的本质以及利他主义和利他行为之间的影响机制。研究发现,受访者都具有一定高水平的利他主义,但意外的是,利他主义似乎不影响利他行为的产生。受访者在决定是否助人时,主要考虑的是自己是否有能力助人,以及他们的核心利益是否会被触犯。西方文献所主张的个体助人行为主要受其同情心及行为前成本效益分析影响的观点并未得到支持。本研究不仅颠覆了许多西方学者的观点,而且增添了中国情境的理论观点。 | Jhony Choon Yeong Ng 郑佳 贾良定 谭清美 | 2018 | 中国青年研究2018，，7： | 24 |
| 4 | 一群去专业化的人——斜杠青年的事业发展研究显示文摘'斜杠青年'的概念在2016年初被引入中国,并影响了数十万年轻人从事多重职业。然而随着现代社会的发展,各行各业的分工越来越细化,职业专业化程度越来越高。在这种专业化的背景下,斜杠青年这种去专业化的职业模式为何能迅速发展的问题亟待研究。本文采用扎根理论的方法 ,对不同地区、不同年龄段的38位工作者进行深入访谈,对斜杠青年这一群体的动因、特征、发展进行探索性研究。研究发现斜杠青年渴望实现自身价值,渴望多姿多彩的生活,并且具备强项是所在专业的边缘技能、技能精进是工作的主要目标两大特征,未来事业发展方向是以技能创业。本文认为,斜杠青年这类去专业化的人群,在企业中不是核心人员,但不可缺少,因此希望日后管理研究能够重视斜杠青年,并且寻求对这类人群的管理方法。 | Jhony Choon Yeong Ng 邵丹慧 贾良定 谭清美 | 2018 | 中国人力资源开发2018，35，6： | 23 |
| 5 | 大学生志愿者志愿行为可持续性研究显示文摘近年来,学者从志愿动机角度探究了影响志愿行为可持续性的因素,从物质和精神两方面构建了大学生志愿者的激励机制,但所取得的效果并不理想。运用经典扎根理论,针对大学生志愿者志愿动机、志愿行为以及志愿服务结束后的后续行为的访谈发现,志愿动机不一定产生志愿行为,志愿者的内心定额、志愿经历储备对于志愿行为的反向作用。 | Jhony Choon Yeong Ng 赵斯琪 谭清美 | 2019 | 当代青年研究2019，0，6： | 19 |
| 6 | Current applications of adipose-derived stem cells and their future perspectives显示文摘Adult stem cells have a great potential to treat various diseases. For these cell-based therapies, adipose-derived stem cells(ADSCs) are one of the most promising stem cell types, including embryonic stem cells(ESCs) and induced pluripotent stem cells(iPSCs). ESCs and iPSCs have taken center stage due to their pluripotency. However, ESCs and iPSCs have limitations in ethical issues and in identification of characteristics, respectively. Unlike ESCs and iPSCs, ADSCs do not have such limitations and are not only easily obtained but also uniquely expandable. ADSCs can differentiate into adipocytes, osteoblasts, chondrocytes, myocytes and neurons under specific differentiation conditions, and these kinds of differentiation potential of ADSCs could be applied in regenerative medicine e.g., skin reconstruction, bone and cartilage formation, etc. In this review, the current status of ADSC isolation, differentiation and their therapeutic applications are discussed. | Eun-Hee Kim Chan Yeong Heo | 2014 | World Journal of Stem Cells2014，6，1： | 19 |
| 7 | 进展期胃癌的外科治疗显示文摘全球每年约有800000例胃癌新发病例,居于最常见的恶性肿瘤第4位,肿瘤相关死亡原因第2位。虽然胃癌发病率在西方国家持续下降,但是在亚洲、拉丁美洲和东欧依旧保持较高水平。据报道,全球大约42%的胃癌患者在中国。随着手术技术的改进、综合治疗方法的进步以及早期诊断能力的提高,最近几十年胃癌的总体生存率得到逐步提升。 | Kyung Min Kim 胡彦锋 Ji Yeong An Hyoung LI Kim Jae Ho Cheong Woo Jin Hyung Sung Hoon Noh | 2011 | 中华消化外科杂志2011，10，6： | 18 |
| 8 | 鲶源维氏气单胞菌的分离鉴定及药敏特性显示文摘为探明发病怀头鲶Silurus soldatovi的病原及其生物学特征,从发病怀头鲶体内分离出1株革兰氏阴性细菌SG-1,通过细菌形态学观察、理化特性、16S r DNA测序和构建系统发育进化树分析对其进行了鉴定。结果表明:分离菌SG-1菌株葡萄糖产气、氧化酶、硝酸盐还原为阳性,鸟氨酸脱羧酶、硫化氢为阴性;进一步采用PCR方法扩增其16S r DNA序列,测序获得片段大小为1409 bp,与维氏气单胞菌Aeromonas veronii模式菌株ATCC35624序列相似性达99.86%;构建系统发育树分析显示,分离菌与维氏气单胞菌自然聚为一支,最终判定SG-1菌株为维氏气单胞菌;人工感染斑马鱼Danio rerio、鲶S.soldatovi,其死亡率均达100%,病鱼呈现体表出血、肛门红肿、腹水等症状;药敏试验结果显示,该菌对头孢克肟、头孢哌酮、头孢噻肟、诺氟沙星、左氟沙星、恩诺沙星、氟苯尼考等药物敏感,对阿莫西林、氨苄西林、磺胺异恶唑、甲氧嘧啶、复方新诺明等耐药。本研究结果为了解维氏气单胞菌感染鲶的致病机理及其该病的预防治疗提供了科学参考。 | 陆梦莹 胡秀彩 吕爱军 孙敬锋 陈成勋 王晓梅 YEONG Yiksung 宋亚娇 | 2017 | 大连海洋大学学报2017，32，5： | 17 |
| 9 | 来华留学研究生与国内研究生协同培养模式研究显示文摘基于协同培养视角,打通国内研究生培养与来华留学研究生培养之间的通道,构建了中外研究生协同培养系统。介绍了中外研究生协同培养模式和具体实施途径,以事例说明了如何形成特色鲜明的来华留学研究生教育模式,并对该模式的顺畅运行提出了具体建议。 | 谭清美 王军华 Jhony Choon Yeong Ng | 2018 | 学位与研究生教育2018，0，12： | 17 |
| 10 | 信息化对老年人生活影响研究——基于智能手机使用情况与感受显示文摘目前中国的信息化正快速发展,当社会享受信息化带来的好处时,老年人未必能够适应信息化社会,反而面临种种不便。故采用经典扎根理论,通过半结构式访谈收集信息,针对信息化对老年人的生活影响开展研究。研究发现:①对于信息化水平较低的老年人来说,信息化对其影响好坏取决于其儿女的关心程度。②对于信息化水平较高的老年人,信息化为其带来丰富的资源,但也造成了身体伤害、与儿女缺乏交流、信息安全隐患等负面影响。基于以上发现,从儿女赡养、城乡一体化建设、老年信息化培训、开发老年信息化市场四个方面提出建议,期望降低信息化对老年人的负面影响。 | JHONY CHOON YEONG NG 陈思璇 谭清美 | 2019 | 南京航空航天大学学报(社会科学版)2019，21，2： | 12 |
| 11 | Improvement of type 2 diabetes mellitus after gastric cancer surgery:Short-term outcome analysis after gastrectomy显示文摘AIM:To evaluate the effect of gastrectomy on diabetes control in patients with type 2 diabetes mellitus and early gastric cancer.METHODS:Data from 64 patients with early gastric cancer and type 2 diabetes mellitus were prospectively collected.All patients underwent curative gastrectomy(36 subtotal gastrectomy with gastroduodenostomy,16subtotal gastrectomy with gastrojejunostomy,12 total gastrectomy)and their physical and laboratory data were evaluated before and 3,6 and 12 mo after surgery.RESULTS:Fasting blood glucose(FBS),HbA1c,insulin,C-peptide,and homeostasis model assessment-estimated insulin resistance were significantly improved 3mo after surgery,regardless of operation type,and the significant improvement in all measured values,except HbA1c,was sustained up to 12 mo postoperatively.Approximately 3.1%of patients stopped diabetes medication and had HbA1c<6.0%and FBS<126 mg/dL.54.7%of patients decreased their medication,and had reduced FBS or HbA1c.In multivariate analysis,good diabetic control was not associated with operation type,but was associated with diabetes duration.CONCLUSION:Diabetes improved in more than 50%of patients during the first year after gastric cancer surgery.The degree of diabetes control was related to diabetes duration. | Ji Yeong An Yoo Min Kim Min Ah Yun Byeong Hee Jeon Sung Hoon Noh | 2013 | World Journal of Gastroenterology2013，19，48： | 11 |
| 12 | Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation显示文摘Macrophage migration inhibitory factor(MIF)is a chemokine that plays an essential role in immune system function.Previous studies suggested that MIF protects neurons in ischemic conditions.However,few studies are reported on the role of MIF in neurological recovery after ischemic stroke.The purpose of this study is to identify the molecular mechanism of neuroprotection mediated by MIF.Human neuroblastoma cells were incubated in Dulbecco’s modified Eagle’s medium under oxygen-glucose deprivation(OGD)for 4 hours and then returned to normal aerobic environment for reperfusion(OGD/R).30 ng/mL MIF recombinant(30 ng/mL)or ISO-1(MIF antagonist;50μM)was administered to human neuroblastoma cells.Then cell cultures were assigned to one of four groups:control,OGD/R,OGD/R with MIF,OGD/R with ISO-1.Cell viability was analyzed using WST-1 assay.Expression levels of brain-derived neurotrophic factor(BDNF),microtubule-associated protein 2(MAP2),Caspase-3,Bcl2,and Bax were detected by western blot assay and immunocytochemistry in each group to measure apoptotic activity.WST-1 assay results revealed that compared to the OGD/R group,cell survival rate was significantly higher in the OGD/R with MIF group and lower in the OGD/R with ISO-1 group.Western blot assay and immunocytochemistry results revealed that expression levels of BDNF,Bcl2,and MAP2 were significantly higher,and expression levels of Caspase-3 and Bax were significantly lower in the MIF group than in the OGD/R group.Expression levels of BDNF,Bcl2,and MAP2 were significantly lower,and expression levels of Caspase-3 and Bax were significantly higher in the ISO-1 group than in the OGD/R group.MIF administration promoted neuronal cell survival and induced high expression levels of BDNF,MAP2,and Bcl2(anti-apoptosis)and low expression levels of Caspase-3 and Bax(pro-apoptosis)in an OGD/R model.These results suggest that MIF administration is effective for inducing expression of BDNF and leads to neuroprotection of neuronal cells against hypoxic injury. | Su Hwan Bae Mi Ran Yoo Ye Yeong Kim In Kyung Hong Mi Hee Kim Seung Hak Lee Dae Yul Kim | 2020 | Neural Regeneration Research2020，15，8： | 11 |
| 13 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 14 | Gastric leptomeningeal carcinomatosis: Multi-center retrospective analysis of 54 cases显示文摘AIM: To identify the clinical features and outcomes of infrequently reported leptomeningeal carcinomatosis (LMC) of gastric cancer.METHODS: We analyzed 54 cases of cytologically confirmed gastric LMC at four institutions from 1994 to 2007.RESULTS: The male-to-female ratio was 32:22, and the patients ranged in age from 28 to 78 years (median,48.5 years). The majority of patients had advanced disease at initial diagnosis of gastric cancer. The clini-cal or pathologic tumor, node and metastasis stage ofthe primary gastric cancer wasin 38 patients (70%).The median interval from diagnosis of the primarymalignancy to the diagnosis of LMC was 6.3 mo, rang-ing between 0 and 73.1 mo. Of the initial endoscopic f indings for the 45 available patients, 23 (51%) of the patients were Bormann typeand 15 (33%) patientswere Bormann type. Pathologically, 94% of cases proved to be poorly differentiated adenocarcinomas. Signet ring cell component was also observed in 40% of patients. Headache (85%) and nausea/vomiting (58%) were the most common presenting symptoms of LMC. A gadolinium-enhanced magnetic resonance imaging was conducted in 51 patients. Leptomeningeal enhancement was noted in 45 cases (82%). Intrathecal (IT) chemotherapy was administered to 36 patients-primarily methotrexate alone (61%), but also in combi-nation with hydrocortisone/± Ara-C (39%). The median number of IT treatments was 7 (range, 1-18). Concomitant radiotherapy was administered to 18 patients, and concomitant chemotherapy to seven patients. Sev-enteen patients (46%) achieved cytological negative conversion. Median overall survival duration from the diagnosis of LMC was 6.7 wk (95% CI: 4.3-9.1 wk). In the univariate analysis of survival duration, hemoglobin, IT chemotherapy, and cytological negative conversion showed superior survival duration (P = 0.038, P = 0.010, and P = 0.002, respectively). However, in our multivariate analysis, only cytological negative conversion was predictive of relatively longer survival duration (3.6, 6.7 and 14.6 wk, P = 0.030, RR: 0.415, 95% CI: 0.188-0.918).CONCLUSION: Although these patients had a fatal clinical course, cytologic negative conversion by IT chemotherapy may improve survival. | Sung Yong Oh Su-Jin Lee Jeeyun Lee Suee Lee Sung-Hyun Kim Hyuk-Chan Kwon Gyeong-Won Lee Jung Hun Kang In Gyu Hwang Joung-Soon Jang Ho Yeong Lim Young Suk Park Won Ki Kang Hyo-Jin Kim | 2009 | World Journal of Gastroenterology2009，15，40： | 10 |
| 15 | Comments to young surgeons concerning laparoscopic spleenpreserving D2 lymph node dissection for advanced gastric cancer on the upper body显示文摘Qualified radical gastrectomy with lymph node dissection is very important to the prognosis of patients with gastric cancer. Now D2 lymph node dissection is standard procedure for gastric cancer surgery, and spleen hilar lymph node dissection is mandatory for gastric cancer in upper body. Because the anatomy of vessels in this area is very complicated, D2 lymph node dissection is technical challenging not only for open gastrectomy but also for laparoscopic one. Adapting a new technique is important to all surgeons, but we surgeons should always consider a patient's safety as the most important factor during surgery and that efforts should be based on scientific rationale with oncologic principles. I hope that the recent report by Huang et al. about laparoscopic spleen preserving hilar lymph node dissection would be helpful to young surgeons who will perform laparoscpic total gastrectomy for gastric cancer. | Yoon Young Choi Ji Yeong An Woo Jin Hyung Sung Hoon Noh | 2014 | Chinese Journal of Cancer Research2014，26，3： | 8 |
| 16 | A laser ablated graphene-based flexible self-powered pressure sensor for human gestures and finger pulse monitoring显示文摘Flexible triboelectric nanogenerators (TENGs)-based pressure sensors are very essential for the wide-range applications, comprising wearable healthcare systems, intuitive human-device interfaces, electronic-skin (e-skin), and artificial intelligence. Most of conventional fabrication methods used to produce high-performance TENGs involve plasma treatment, photolithography, printing, and electro-deposition. However, these fabrication techniques are expensive, multi-step, time-consuming and not suitable for mass production, which are the main barriers for efficient and cost-effective commercialization of TENGs. Here, we established a highly reliable scheme for the fabrication of a novel eco-friendly, low cost, and TENG-based pressure sensor (TEPS) designed for usage in self-powered-human gesture detection (SP-HGD) likewise wearable healthcare applications. The sensors with microstructured electrodes performed well with high sensitivity (7.697 kPa^-1), a lower limit of detection (~ 1 Pa), faster response time (< 9.9 ms), and highly stable over > 4,000 compression-releasing cycles. The proposed method is suitable for the adaptable fabrication of TEPS at an extremely low cost with possible applications in self-powered systems, especially e-skin and healthcare applications. | Partha Sarati Das Ashok Chhetry Pukar Maharjan M. Salauddin Rasel Jae Yeong Park | 2019 | Nano Research2019，12，8： | 8 |
| 17 | Voltage-gated K+ channels in adipogenic differentiation of bone marrow-derived human mesenchymal stem cells显示文摘 | Mi-hyeon YOU Min Seok SONG Seul Ki LEE Pan Dong RYU So Yeong LEE Dae-yong KIM | 2013 | Acta Pharmacologica Sinica2013，34，1： | 7 |
| 18 | 金鱼腐皮病病原菌的分离鉴定及药敏试验显示文摘从患腐皮病金鱼肝脏中分离获得1株细菌,编号为KL-1,通过细菌形态观察、生理生化特性、16S rDNA克隆测序及构建发育树分析等系统鉴定,并进行动物感染试验、药敏特性研究。结果表明,KL-1菌株为革兰氏阴性短杆菌,可发酵葡萄糖产气,氧化酶、接触酶、赖氨酸脱羧酶等为阳性;进一步采用PCR方法扩增16S rDNA序列,将其亚克隆至p MD18-T载体中,测序获得长度为1 507 bp,与Aeromonas veronii模式菌株ATCC 35624(X74684)序列相似性为99.66%,构建系统进化树分析与其聚为一支,鉴定KL-1菌株为维氏气单胞菌(Aeromones veronii)。动物感染试验表明,对斑马鱼半数致死量LD50为1.4×107 cfu/m L。药敏试验结果显示,该病原菌对头孢克肟、头孢哌酮、头孢噻肟、头孢氨苄、萘啶酸、恩诺沙星、左氟沙星、诺氟沙星、氟苯尼考和氯霉素等药物敏感。 | 康雪微 胡秀彩 孙金辉 孙敬锋 吕爱军 宋亚娇 YEONG Yiksung 石洪玥 郭立 | 2017 | 天津农学院学报2017，24，2： | 7 |
| 19 | 国外典型军民融合发展模式的借鉴和启示显示文摘军民融合是一个不断深化、自主创新的过程。然而,借鉴发达国家军民融合发展的模式和政策是必要的、有意义的。典型国家如美国、俄罗斯、英国等基本上都经历了'军民分离'到'以军养民'再到'军民融合'的发展历程。通过分析典型国家军民融合发展的动因、模式和政策,可以得到一些启示:一是建立军民产品统一标准规范,消除军民融合的技术壁垒;二是健全军民两用技术发展的法律、法规和政策;三是实现军民融合政策与经济社会发展实践相协调;四是选择适合本国国情和军情的军民融合发展模式。 | 谭清美 杨凌波 Jhony Choon Yeong Ng | 2018 | 南京理工大学学报(社会科学版)2018，31，2： | 7 |
| 20 | 基于“三条链”的无人机产业军民融合发展途径与策略显示文摘军民融合是国家重大发展战略,现有文献主要关注军民融合过程中的具体问题,缺乏综合性分析。基于产业生态系统“三条链”视角,以无人机产业为例,通过构建无人机产业生态系统的“三条链”,深入探讨无人机产业军民融合发展途径和策略。研究发现,从创新链角度构建军民融合研发创新平台、从产业链角度生产军民两用无人机、从价值链角度在研发环节成立技术联盟、在销售环节合力扩大彼此销售范围是无人机产业军民融合发展的有效途径和策略,该结论同样对其它产业军民融合发展具有指导作用。 | 谭清美 马俊华 Jhony Choon Yeong Ng | 2019 | 科技进步与对策2019，36，14： | 7 |
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