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| 1 | Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats显示文摘AIM: To investigate the therapeutic effects of DA-9601 on sodium taurocholate (TCA)-induced chronic reflux gastritis in SD rats.METHODS: In this study, we have investigated the therapeutic effects of DA-9601 on chronic erosive and atrophic gastritis induced by 6 mo of TCA administration (5 mmol/L in drinking water) in SD rats. RESULTS: Four weeks of DA-9601 administration (0.065%, 0.216% in rat chow), following the withdrawal of TCA treatment, resulted in a significant decrease in total length of erosions in rats in a dose-dependent manner. Furthermore, the indicators of atrophic gastritis, such as reduced mucosal thickness and reduction in the number of parietal cells, were improved by the administration of DA-9601 in a dose-related manner. DA-9601 also attenuated inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa. The improvement in the reduction of the gastric mucus was observed in the rats receiving a high dose of DA-9601 (0.216%). The therapeutic effect of DA-9601 on experimental chronic erosive gastritis was superior to that of rebamipide (1.08% in rat chow). Biochemical analyses showed increased mucosal prostaglandin E2 and reduced glutathione levels by DA-9601 treatment. CONCLUSION: We suggest that DA-9601 is apromising agent for the treatment of chronic erosive and atrophic gastritis with an etiological factor of bile reflux. Increasedmucosal prostaglandin E2 and reduced glutathione by DA-9601 treatment may be therapeutic mechanisms for chronic erosive and atrophic gastritis. | Tae Young Oh Chang Yell Shin Yong Sung Sohn Dong Hwan Kim Byoung Ok Ahn Eun Bang Lee Cho Hyun Park | 2005 | World Journal of Gastroenterology2005，11，47： | 5 |
| 2 | 利用曲线面变形提取产品形态体特征的方法研究显示文摘在变形设计理论的基础上,提出了将产品主体形态分解为子形态。研究了基于超椭圆方程和三次带参均匀B样条曲线构造技术提取影响产品艺术风格子形态横截面造型特征的方法,并结合曲面构造变形技术实现产品形态体特征的提取。以电动手工具为例研究了产品形态体特征提取与形态优化设计效果,得出超椭圆方程提取算法参数少,可较好地提取对称图形、非倒角图形的造型特征;基于三次带参均匀B样条曲线构造技术的算法参数较多,可较好地提取多种图形。 | 王毅 王家民 Richard Wilfred Yelle 胡钢 | 2015 | 机械科学与技术2015，34，1： | 2 |
| 3 | Litter decay rates are determined by lignin chemistry显示文摘 | Talbot JM Yelle DJ Nowick J Treseder KK | 2012 | Biogeochemistry2012，108，13： | 1 |
| 4 | Effect of atmospheric CO2 concentration and root-zone temperature on growth, mineral nutrition and nitrate reductase activity of greenhouse tomato显示文摘 | Gosselin A Trudel M J | 1987 | J Amer Soc Hort Sci1987，112，6： | 1 |
| 5 | The learning curves: historical review and compre- hensive survey 显示文摘 | YELLE L E | 1979 | Decis Sci1979，10，2： | 1 |
| 6 | Review of parameter identification procedures in groundwater hydrology: The inverse problem显示文摘 | Yell G- T | 1986 | Water Resources Research1986，22，2： | 1 |
| 7 | Evidence for the involvement of sucrose phosphate synthase in the pathway of sugar accumulation in sucrose-accumulating tomato fruits显示文摘 | DALI N MICHAUD D YELLE S | 1992 | Plant Physiol1992，99，2： | 1 |
| 8 | Evidence for the involvement of suerose-phosphate synthase in the pathway of sugar accumulation in suemse-accumulating tomato fruits 显示文摘 | Dali N Michaud D Yelle S | 1992 | Plant Physiol1992，99，： | 1 |
| 9 | Rhamnolipid production with indigenous Pseudomonas aeruginosa EM1 isolated from oil-contaminated site 显示文摘 | Jane Yii Wu Kuei Ling Yell WeiBin Lu | 2008 | Bioresource Technology2008，99，： | 1 |
| 10 | The ever-t evolving role of mTOH in translation显示文摘 | Fonseca BD Smith EM Yelle N et ai | 2014 | Semin Cell Dev Biol2014，36，： | 1 |
| 11 | Convenient Synthesis of Methyl 1-Methyl-2,4-dibromo-5-imidazole- carboxylate显示文摘 | OCONNELL J F PARQUETTE J YELLE W E | 1988 | Synthesis1988，，2： | 1 |
| 12 | The learning curve:Historical review and comprehensive survey显示文摘 | Yelle L E | 1979 | Decision Sciences1979，10，2： | 1 |
| 13 | Evidence For the involvement of Sucrose Phosphate synthase in the pathway of sugar accumulation in su- crose - accumulating tomato fruits 显示文摘 | DALI N MICHAUD D YELLE S | 1992 | Plant Physiol1992，99，2： | 1 |
| 14 | Evidence for the involvement of sucrose phosphate synthase in the pathway of sugar accumulation in sucrose accumulating tomato fruits显示文摘 | Dali N Michaud D Yelle S | 1992 | Plant Physiol1992，99，： | 1 |
| 15 | Effects of parenteral structured lipid emulsion on modulating the inflammatory response in rats undergoing a total gastrectomy显示文摘 | LIN MT YEll SL TSOU SS | 2009 | Nutrition2009，25，1： | 1 |
| 16 | Purification of tomato sucrose synthase phosphorylated isobrms by Fe(Ill)-immobilized metal affinity chromatography显示文摘 | Anguenot R Yelle S Nguyen-Quoc B | 1999 | Arch Biochem Biophys1999，365，1： | 1 |
| 17 | Lignin fate and characterization during ionic liquid biomass pretreatment for renewable chemicals and fuels production显示文摘 | SATHITSUKSANOH N HOLTMAN K M YELLE D J | 2014 | Green Chemistry2014，16，3： | 1 |
| 18 | Tomato Fruit Acid Invertase Complementary DNA显示文摘 | Yelle S Bennett A B | 1992 | Plant Physiol1992，99，： | 1 |
| 19 | Funclional connectivity ofliip|>m_ani|>al networks in temporal l?l>e epilepsy 显示文摘 | Haneef Z Lenartowirz A Yell | 2014 | Kpil^psia2014，55，： | 1 |
| 20 | Topical photodynamictherapy in disseminated superficial actinic porokeratosis 显示文摘 | Nayeemuddin FA Wong M Yell J | 2002 | ClinExp Dermatol2002，27，8： | 1 |
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