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| 1 | NG2 Cell Response in the CNP-EGFP Mouse After Contusive Spinal Cord Injury显示文摘成年动物中枢神经系统中的NG2细胞具有异质性。脊髓损伤(SCI)后,具有少突胶质前体细胞(OPCs)功能的NG2细胞亚型如何产生反应性变化及对其正常的发育过程有何影响目前还不清楚。本文采用少突胶质细胞系细胞表达EGFP的CNP-EGFP小鼠,研究正常和SCI后的NG2细胞的特征。在正常小鼠的白质中,对EGFP+NG2+双极细胞和EGFPnegNG2+多极细胞进行鉴别。SCI后,白质损伤边缘区中的EGFP+NG2+细胞3 d增殖达高峰,损伤中心区的EGFPnegNG2+细胞增殖在损伤后7 d达高峰。损伤后EGFP+NG2+细胞的Olig2、Sox10、Sox17等转录因子、基本的膜电生理参数以及钾电流表型均与发育过程增殖的OPCs一致。EGFPnegNG2+细胞不表达少突胶质发生中的转录因子。EGFP+CC1+少突胶质细胞6周时包含在EGFP+NG2+细胞增殖峰时表达BrdU的细胞。EGFPnegCC1+少突胶质细胞未被观察到。神经胶质生长因子2和成纤维细胞生长因子2处理促进少突胶质发生,提高EGFPnegNG2+细胞数量。因此,通过EGFP和转录因子表达,时空增殖类型及对生长因子的反应,两种类型的NG2+细胞对SCI刺激发生反应。SCI后EGFP+NG2+细胞经受细胞和生理变化特征,与在早期出生后的少突胶质发生过程中NG2+细胞中的变化类似。 | JUDITH M LYTLE RAMESH CHITTAJALLU JEAN R WRATHALL VITTORIO GALLO | 2009 | 神经损伤与功能重建2009，4，1： | 7 |
| 2 | Spinal cord contusion in the rat:behavioral analysis of functional neurological impairment显示文摘 | kerasidis H Wrathall JR | 1985 | Exp Neurol1985，88，： | 1 |
| 3 | Increase of interleukin-1 beta mRNA and protein in the spinal cord following experimental traumatic injury in the rat显示文摘 | WANG C X OLSCHOWKA J A WRATHALL J R et al | 1997 | Brain Res1997，759，2： | 1 |
| 4 | Spinal cord contusion in the rat:production of graded,reproducible,injury groups显示文摘 | Wrathall JR Pettegrew RK Harvey F | 1985 | Exp Neurol1985，88，1： | 1 |
| 5 | Glutamate receptor subunit expression after spinal cord injury in young rats显示文摘 | Brown KM Wrathall JR Yasuda RP | 2004 | Brain Res Dev Brain Res2004，152，： | 1 |
| 6 | Spinal cord contusion in the rat:behavioral analysis of functional neurologic impairment显示文摘 | Gale K kerasidis H Wrathall JR | 1985 | Exp Neurol1985，88，： | 1 |
| 7 | Spinal cord contusion in therate : production of graded,reproducible injury groups 显示文摘 | Wrathall JR Pettegrew RW Harey F | 1985 | Exp Neu-rol1985，88，： | 1 |
| 8 | Glutamate receptor subunit expression after spinal cord injury in young rats显示文摘 | Brown KM Wrathall JR Yasuda RP | 2004 | Brain Res Dev Brain Res2004，152，： | 1 |
| 9 | Temporal-spatial patern of acute neuronal and glial loss after spinal cord contusion显示文摘 | Grossman SD Rosenbery LJ Wrathall JR | 2001 | Exp Neurol2001，168，： | 1 |
| 10 | Spinal cord contusion in the rat : behavioral analysis of functional neurologic impairment显示文摘 | Kerasidis H Wrathall JR | 1985 | Exp Neurol1985，88，1： | 1 |
| 11 | Quantitative analysis of acute axonal pathology in experimental spinal cord contusion 显示文摘 | Rosenberg LJ and Wrathall JR | 1997 | J Neurotrauma1997，14，11： | 1 |
| 12 | Increase of interleukinlbeta mRNA and protein in the spinal cord following experimental traumatic injury in the rat显示文摘 | Waag CX Olschowka JA Wrathall JR | 1997 | Brain Res1997，759，2： | 1 |
| 13 | Spinal cord contusion in the rat:production of graded,reproducible,injury groups 显示文摘 | Wrathall JR Pettegrew RW Harvey F | 1985 | Exp Neutrol1985，88，： | 1 |
| 14 | Effect of injury severity on lower urinary tract function after experimental spinal cord injury 显示文摘 | Wrathall JR Emch GS | 2006 | Prog Brain Res2006，152，： | 1 |
| 15 | Expression of tumor necrosis factor alpha and its mRNA in the spinal cord following a weight-drop injury 显示文摘 | Wang C X Reece C Wrathall J R | 2002 | Neuroreport2002，13，11： | 1 |
| 16 | Expression of tumor necrosis factor alpha and its mRNA in the spinal cord following a weight-drop injury显示文摘 | Wang CX Reece C Wrathall JR | 2002 | J Neuroreport2002，13，11： | 1 |
| 17 | Spinal cord contusion in the rat: production of graded, reproducible, injury groups显示文摘 | Wrathall JR Pettegrew RK Harvey F | 1985 | Exp Neurol1985，88，1： | 1 |
| 18 | Spinal cord contusion in the rat:behavioral analysis of functional neurologic impairment显示文摘 | Gale K Kerasidis H Wrathall JR | 1985 | Exp Neurol1985，88，1： | 1 |
| 19 | Spinal cord contusion in the rat: production of graded, reproducible, injury groups显示文摘 | WRATHALL J R PETTEGREW P K HARVEY F | 1985 | Exp Neurol1985，88，1： | 1 |
| 20 | Basic and acidic fibroblast growth factors protect spinal motor neurons in vivo after experimental spinal cord injury显示文摘 | Teng YD Mocchetti I Wrathall JR | 1998 | Eur J Neurosci1998，10，2： | 1 |
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