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| 1 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 2 | The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method,but with a better survival rate显示文摘 | Cechetti F Worm P V Pereira L O | 2010 | Braz J Med Biol Res2010，43，12： | 1 |
| 3 | Chronic brain hypoperfusion causes early glial activation and neuronal death,and subsequent long-term memory impairment 显示文摘 | Cechetti F Pagnussat A S Worm P V | 2012 | Brain Res Bull2012，87，1： | 1 |
| 4 | Chronic brain hypoperfu- sion causes early glial activation and neuronal death, and subsequent long-term memory impairment 显示文摘 | Cechetti F Pagnussat AS Worm PV | 2012 | Brain Res Bull2012，87，1： | 1 |
| 5 | Chronic brain hypoperfu- sion causes early glial activation and neuronal death, and subsequent long-term memory impairment 显示文摘 | Cechetti F Pagnussat AS Worm PV | 2012 | Brain Res Bull2012，87，1： | 1 |
| 6 | Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells 显示文摘 | WORM J KIRKIN A F DZHANDZHUGAZYAN K N | 2001 | J Biol Chem2001，276，39： | 1 |
| 7 | The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method, but with a better survival rate显示文摘 | Cechetti F Worm PV Pereira LO | 2010 | Braz J Med Biol Res2010，43，12： | 1 |
| 8 | Uptake and retention of hexakis(z-methoxy isobutyl isonitrile) technetium(I)in cultured chick myocardial dependence显示文摘 | Piwniaca Worms D Kronange J F Chiu ML | 1990 | Circulation1990，82，： | 1 |
| 9 | Chronic brain hypoper-fusion causes early glial activation and neuronal death, and subsequent long-term memory impairment 显示文摘 | Cechetti F Pagnussat AS Worm PV | 2012 | Brain Res Bull2012，87，： | 1 |
| 10 | Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment 显示文摘 | CECHETTI F PAGNUSSAT AS WORM PV | 2012 | Brain Res Bull2012，87，1： | 1 |
| 11 | ETV6-NTRK3 gene fusion in a secretory carcinoma of the breast of a male-to-female transsexual显示文摘 | Grabellus F Worm K Willruth A | 2005 | Breast2005，14，1： | 1 |
| 12 | Some effects of mandibular growth on the dental occulusion and profile显示文摘 | ISSAOSON R J ZAPFEL R J WORMS F W | 1977 | Angle Orthod1977，47，2： | 1 |
| 13 | Chronic brain hypoper- fusion causes early glial activation and neuronal death,and subsequent long-term memory impairment显示文摘 | Cechetti F Pagnussat A S Worm P V | 2012 | Brain Res Bull2012，87，1： | 1 |
| 14 | Development of a highly sensitive and specific method for detection of circulating tumor cells harboring somatic mutations in non-small-cell lung cancer patients显示文摘 | Breitenbuecher F Hoffarth S Worm K | 2014 | PLoS One2014，9，85： | 1 |
| 15 | The modified 2VO is- chemia protocol causes cognitive impairment similar to that induced by the standard method,but with a better survival rate显示文摘 | Cechetti F Worm P V Pereira L O | 2010 | Braz J Med Biol Res2010，43，12： | 1 |
| 16 | The diagnosis of multiple system atrophy 显示文摘 | Geser F Worming GK | 2006 | J Neurol2006，253，： | 1 |
| 17 | The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method,but with a better survival rate显示文摘 | Cechetti F Worm PV Pereira LO | 2010 | Braz J Med Biol Res2010，43，12： | 1 |
| 18 | The m- odified CICI ischemia protocol causes cognitive impairment similar to that induced by the standard method, but with a better survival rate 显示文摘 | CECHETFI F WORM P V PEREIRA L O | 2010 | Braz J Med Biol Res2010，43，12： | 1 |
| 19 | Tooth-size discrepancy in mandibularprognathism显示文摘 | SPERRY T P WORMS F W ISAACSON R J | 1977 | Am J Orthod1977，72，2： | 1 |
| 20 | The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method,but with a better survival rate显示文摘 | Cechetti F Worm P V Pereira L O | 2010 | Braz J Med Biol Res2010，43，12： | 1 |
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