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| 1 | Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis显示文摘AIM To characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis(PSC) and ulcerative colitis(UC).METHODS Stool samples were collected and relevant clinical data obtained from 106 study participants, 43 PSC patients with(n = 32) or without(n = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 healthy controls. The V3 and V4 regions of the 16 S ribosomal RNA gene were sequenced on Illumina Mi Seq platform to cover low taxonomic levels. Data were further processed in QIIME employing Ma As Lin and LEf Se tools for analysis of the output data.RESULTS Microbial profiles in both PSC and UC were characterized by low bacterial diversity and significant change in global microbial composition. Rothia, Enterococcus, Streptococcus, Veillonella, and three other genera were markedly overrepresented in PSC regardless of concomitant inflammatory bowel disease(IBD). Rothia, Veillonella and Streptococcus were tracked to the species level to identify Rothia mucilaginosa, Streptococcus infantus, S. alactolyticus, and S. equi along with Veillonella parvula and V. dispar. PSC was further characterized by decreased abundance of Adlercreutzia equolifaciens and Prevotella copri. Decrease in genus Phascolarctobacterium was linked to presence of colonic inflammation regardless of IBD phenotype. Akkermansia muciniphila, Butyricicoccus pullicaecorum and Clostridium colinum were decreased in UC along with genus Roseburia. Low levels of serum albumin were significantly correlated with enrichment of order Actinomycetales.CONCLUSION PSC is associated with specific gut microbes independently of concomitant IBD and several bacterial taxa clearly distinguish IBD phenotypes(PSC-IBD and UC). | Lukas Bajer Miloslav Kverka Martin Kostovcik Peter Macinga Jiri Dvorak Zuzana Stehlikova Jan Brezina Pavel Wohl Julius Spicak Pavel Drastich | 2017 | World Journal of Gastroenterology2017，23，25： | 22 |
| 2 | Identifying and mitigating dam-induced declines in river health:Three case studies from the western United States显示文摘河健康能被定义为河流的精力来源,水质量,流动政体,产地和生物区系匹配自然条件到的度。在一条健康的河里,物理过程和形式遗体活跃地连接了并且能互相调整、生物社区有差异的自然层次并且对环境应力有弹性。物理差异和生物多样性影响河健康。物理差异被水文学, hydraulics,和底层管理,在河隧道和邻近的泛滥平原的几何学思考了它为水、河边的有机体创造产地。生物多样性被象竞争和 predation 那样的生物过程管理,但是生物多样性也反映产地,以及连接的差异,丰富和稳定性。在一个河走廊以内的连接包括纵、侧面、垂直的尺寸。当任何这些交往的部件被人的活动损害,河健康衰退。水坝的累积效果和河的另外的人的改变主要是直接减少物理差异和连接,它间接地减少生物多样性。在水坝影响的河里的物理差异和生物多样性的恢复和维护要求在流动和沉积的驱动程序变量之间的确定的关系供应,和产地,连接,和生物社区的反应变量。这些关系能拿阀值的形式(例如, streambed 沉积的乘火车) 或反应曲线(例如,泛滥平原淹没的鱼生物资源对程度和持续时间) 。我在西方的美国从怀俄明,科罗拉多,和亚利桑那使用例子说明怎么确定在在河里的司机和反应变量之间的关系由水坝影响了。 | Ellen WOHL | 2012 | International Journal of Sediment Research2012，27，3： | 3 |
| 3 | Epithelial markers of colorectal carcinogenesis in ulcerative colitis and primary sclerosing cholangitis显示文摘AIM:To evaluate the expression of epithelial markers of colorectal carcinogenesis in patients with long-term ulcerative colitis(UC) and primary sclerosing cholangitis(PSC) before and after transplantation.METHODS:Eight patients with UC and PSC prior to liver transplantation(PSC-UC),22 patients with UC after liver transplantation for PSC(OLT),9 patients with active ulcerative colitis without PSC(UCA),7 patients withUC in remission(UCR) and 10 controls(N) underwent colonoscopy with multiple biopsies.Specimens were analysed histologically and semi-quantitatively immunohistochemically for p53,Bcl-2 and cyclooxygenase-2(COX-2) markers.Statistical analysis was performed by Kruskal-Wallis and Fisher's exact tests.RESULTS:PSC-UC had a statistically significantly higher expression of p53 in the nondysplastic mucosa as compared to OLT,UCA,UCR and N(P < 0.05).We also found a statistically significant positive correlation between the incidence of PSC and the expression of p53(P < 0.001).UCA had a higher p53 expression as compared to UCR.OLT had a significantly lower expression of p53 as compared with PSC-UC(P < 0.001).Bcl-2 had a significant higher bcl-2 expression as compared with controls.No difference in COX-2 expression between PSC-UC,UCR and UCA was found.UCA had higher COX-2 expression as compared to UCR.We also found a statistically significant positive correlation between the expression of COX-2 and p53.Patients after liver transplantation for PSC had a statistically significantly lower expression of the p53 compared with PSCUC(P < 0.001).PSC-UC had the same inflammatory endoscopic activity as OLT and UCR when evaluated with the Mayo score.CONCLUSION:Our study shows that the nondysplatic mucosa of UC patients with PSC is characterised by a higher expression of the tumour suppressor gene p53,suggesting a higher susceptibility of cancer.This p53 overexpression correlates with the presence of PSC whilst it is not present in patients with UC after liver transplantation for PSC. | Pavel Wohl Tomas Hucl Pavel Drastich David Kamenar Julius Spicak Eva Honsova Eva Sticova Alena Lodererova Jan Matous Martin Hill Petr Wohl Milos Kucera | 2013 | World Journal of Gastroenterology2013，19，14： | 2 |
| 4 | Do Investors Prefer Round Stock Prices? Evidence from Israeli IPO Auctions显示文摘 | KANDEL S SARIG O WOHL A | 2001 | Journal of Banking and Finance2001，25，8： | 1 |
| 5 | Atomoxetine: a new treatment for attention deficit/hyperactivity disorder (AD- HD) in children and adolescents 显示文摘 | Purper-Ouakil D Fourneret P Wohl M | 2005 | Encephale2005，31，3： | 1 |
| 6 | Geological hazards,vulnerability,and risk assessment using GIS:model for Glenwod Springs,Colorado显示文摘 | Mejia-Navarro M Wohl E E Oaks S D | 1994 | Geomorphology1994，10，1： | 1 |
| 7 | Current concepts in the diagnosis and management of metabolic complications of HIV infection and its therapy 显示文摘 | Wohl D A McComsey G Tebas P | 2006 | Clinical Infectious Diseases2006，43，5： | 1 |
| 8 | Retinoic acid enhances neuronal proliferation and astroglial differentiation in cultures of CNS stem cell-derived precursors显示文摘 | Wohl CA Weiss S | 1998 | J Neurobiol1998，37，2： | 1 |
| 9 | River restoration 显示文摘 | WOHL E ANGERMEIER P L BLEDSOE B | 2005 | Water Resources Research2005，41，10： | 1 |
| 10 | The effects of near wins and near losses on self- perceived personal luck and subsequent gambling behavior显示文摘 | Wohl M Enzle M | 2003 | Journal of Experimental Social Psychology2003，，39： | 1 |
| 11 | Nylon 6 RIM显示文摘 | Hedrick R M Gabbert J D Wohl M H | 1985 | ACS Symposium Series1985，，： | 1 |
| 12 | Long river profiles, tectonism, and eustasy: A guide to interpreting fluvial terraces 显示文摘 | Merritts D J Vincent K R Wohl E E | 1994 | Journal of Geophysical Research1994，99，14： | 1 |
| 13 | Organic electroluminescent device with a three layer structure显示文摘 | WOHL A MARCKWALD W | 2000 | Jpn Appl Phys2000，27，8： | 1 |
| 14 | Cilioretinal collateral circulation after occlusion of the central retinal artery显示文摘 | Marmor MF Jampol LM Wohl L | 1985 | Br J Ophthalmol1985，69，： | 1 |
| 15 | Late unheralded pacemaker pocket infection due to staphylocoaus epidermitis: aniw clinical entity 显示文摘 | Wohl B peters RW Carliner N | 1982 | PACT1982，5，： | 1 |
| 16 | Geological hazards, vulnerability, and risk assessment using GIS: Model for Glen- wood Springs, Colorado 显示文摘 | Navarro M M Wohl E E Qaks S D | 1994 | Geomorphology1994，10，： | 1 |
| 17 | Acute generalized exanthematous pustulosis: a retrospective analysis showing a clear predilection for women 显示文摘 | Tamir E Wohl Y Mashiah J | 2006 | Skinmed2006，5，4： | 1 |
| 18 | A comparison of surface sampling methods for coarse fluvial sediments显示文摘 | WOHL E E ANTHONY D J | 1996 | Water Resour Res1996，32，： | 1 |
| 19 | Survival in patients with HIV infection and viral hepatitis B or C: a cohort study显示文摘 | Maurizio Bonacini Stan Louie Natalie Bzowej Amy Rock Wohl | 2004 | AIDS2004，，15： | 1 |
| 20 | Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvite- gravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection : two randomised, double-blind, phase 3, non- inferiority trials 显示文摘 | SAX P E WOHL D YIN M T | 2015 | Lancet2015，385，9987： | 1 |
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