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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 3 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 4 | Reliability of the pronator quadratus fat pad sign to predict the severity of distal radius fractures显示文摘AIM To evaluate the reliability of pronator quadratus fat pad sign to detect distal radius fracture and to predict its severity.METHODS Retrospectively we identified 89 consecutive patients(41 female, mean age 49 ± 18 years) who had X-ray(CR) and computed tomography(CT) within 24 h following distal forearm trauma. Thickness of pronator quadratus fat pad complex(PQC) was measured using lateral views(CR) and sagittal reconstructions(CT). Pearson's test was used to determine the correlation of the PQC thickness in CR and CT. A positive pronator quadratus sign(PQS) was defined as a PQC > 8.0 mm(female) or > 9.0 mm(male). Frykman classification was utilized to assess the severity of fractures.RESULTS Forty-four/89 patients(49%) had a distal radius fracture(Frykman Ⅰ n = 3, Ⅱ n = 0, Ⅲ n = 10, Ⅳ n = 5, Ⅴ n = 2, Ⅵ n = 2, Ⅶ n = 9, Ⅷ n = 13). Mean thickness of the PQC thickness can reliably be measured on X-ray views and was 7.5 ± 2.8 mm in lateral views(CR), respectively 9.4 ± 3.0 mm in sagittal reconstructions(CT), resulting in a significant correlation coefficientof 0.795. A positive PQS at CR was present in 21/44 patients(48%) with distal radius fracture and in 2/45 patients(4%) without distal radius fracture, resulting in a specificity of 96% and a sensitivity of 48% for the detection of distal radius fractures. There was no correlation between thickness of the PQC and severity of distal radius fractures.CONCLUSION A positive PQS shows high specificity but low sensitivity for detection of distal radius fractures. The PQC thickness cannot predict the severity of distal radius fractures. | Julia Loesaus Isabel Wobbe Erik Stahlberg Joerg Barkhausen Jan Peter Goltz | 2017 | World Journal of Radiology2017，9，9： | 3 |
| 5 | Matrix metalloproteinase 2 and 9 activity in patients with colorectal cancer liver metastasis 显示文摘 | Waas ET Wobbes T Lomme RM | 2003 | Br J Surg2003，90，12： | 1 |
| 6 | Epitheli- oid sarcoma: Still an only surgically curable disease 显示文摘 | de Visscher S A van Ginkel R J Wobbes T etal | 2006 | Cancer2006，107，3： | 1 |
| 7 | The significance of microcalcifications without palpable mass in the diagnosis of breast cancer显示文摘 | Tinnemans JG Wobbes T Lubbers E J | 1986 | Surgery1986，99，6： | 1 |
| 8 | Characterization of Reinforced Concrete Beams Strengthened by Steel Reinforced Polymer and Grout (SRP and SRG) Composites显示文摘 | BARTON B WOBBE E DHARANI L R | 2005 | Materials Science Engineering A2005，412，12： | 1 |
| 9 | Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo显示文摘 | Rupp J Hellwig-Burgel T Wobbe V | 2005 | Proc Natl Acad Sci USA2005，102，9： | 1 |
| 10 | Epithelioid sarcoma:still an only SUr cally curable disease显示文摘 | de Visscher S A van Ginkel R J Wobbes T | 2006 | Cancer2006，107，3： | 1 |
| 11 | The effect of aggressive versus conventional lipid-lowering therapy on markers of inflammatory and oxidative stress 显示文摘 | Mulder D J van Haelst PL Wobbes MH | 2007 | Cardiovasc Drugs Ther2007，21，2： | 1 |
| 12 | Trehalose Mediated Growth Inhibition of Arabidopsis Seedlings Is Due to Trehalose - 6 - Phosphate Accumulation 显示文摘 | Schluepmann H Dijken A Aghdasi M Wobbes B Paul M and Smeekens S | 2004 | Plant Physiology2004，135，： | 1 |
| 13 | Magnetic resonance guided biopsies and localizations of the breast:initial experiences using an open breast coil and compatible intervention device显示文摘 | Veltman J Boetes C Wobbes T | 2005 | Invest Ra- diol2005，40，6： | 1 |
| 14 | The effects of intraoperative hypothermia on surgical site infection:an analysis of524trauma laparotomies显示文摘 | Seamon MJ Wobb J Gaughan JP | 2012 | Ann Surq2012，255，4： | 1 |
| 15 | Epithelioid sarcoma:still an only surgically curable disease显示文摘 | de Visscher SA van Ginkel RJ Wobbes T | 2006 | Cancer2006，107，3： | 1 |
| 16 | The effects of intra- operative hypothermia on surgical site infection:an analysis of 524 trauma laparotomies 显示文摘 | Seamon M J Wobb J Gaughan JP | 2012 | Annals of surgery2012，255，4： | 1 |
| 17 | Matrix meatalloproteinase 2 and 9 activity in patients with colorectal cancer live metastasis显示文摘 | Waas ET Wobbes T Lomme RM | 2003 | Br J Surg2003，90，12： | 1 |
| 18 | Malignant Adenomyoepithelioma of the breast with metastasis in the thyroid gland 12 years after excision of the primary tumor显示文摘 | Bult P Verwiel J M Wobbes T | 2000 | Virchows Arch2000，436，2： | 1 |
| 19 | Evaluation of seven tumor markers (CA 50, CA 19-9, CA 19-9 Tru- Quant, CA 72-4, CA 195, carcinoembryonic antigen, and tissue polypeptide antigen) in the pretreatment sera of pa- tients with gastric carcinoma显示文摘 | Wobbes T Thomas CM Segers MF | 1992 | Cancer1992，69，8： | 1 |
| 20 | Malignant adenomyoepitheli- oma of the breast with metastasis in the thyroid gland 12 years after excision of the primary tumor Case report and review of the literature 显示文摘 | Buh P Verwiel JM Wobbes T | 2000 | Virchows Arch2000，436，2： | 1 |
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