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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | Experimental Investigation of the Flame Propagation and Flashback Behavior of a Green Propellant Consisting of N2O and C2H4显示文摘 | Lukas Werling Felix Lauck Dominic Freudenmann Nicole Rocke Helmut Ciezki Stefan Schlechtriem | 2017 | Journal of Energy and Power Engineering2017，11，12： | 6 |
| 3 | 不均匀电场中温度对油纸绝缘沿面放电特性的影响显示文摘采用针-板电极结构研究不均匀电场中温度对变压器油纸绝缘沿面放电特性的影响。首先,确定油纸绝缘的局部放电起始电压和闪络电压。然后,在油纸界面上施加恒定电压,研究在不同温度下施加长期电压时油纸绝缘的沿面放电特性。结果表明:局部放电起始电压和闪络电压随温度升高而增加。施加长期电压时,高油温下,油纸绝缘沿面放电现象和纸板变化情况更为复杂。纸板在高油温下更容易发生碳化。虽然碳化会对纸板造成不可逆的损坏,但仅在表面发生碳化的纸板在恒定电压下表现出更长的耐压时间和更低的局部放电量与放电重复率。然而,在内部发生严重碳化时,其局部放电重复率变得更高,最终导致纸板击穿。 | 黎颖 周欣 Werle P 郑晓泉 | 2018 | 绝缘材料2018，51，6： | 5 |
| 4 | Arthropods and biofuel production systems in North America显示文摘 | Douglas A. Landis Benjamin P. Werling | 2010 | Insect Science2010，17，3： | 5 |
| 5 | 建筑自然:场所营造显示文摘夏日凉亭通常提供至少三种设施:坐席、阴凉和避雨处.而藤本壮介为蛇形画廊设计的夏季展馆像一团离群的云朵,漂浮在肯辛顿花园的空地上,从远处观看,人们无从得知它是否具有以上任何一种功能.只有靠近观察,纤细的白色椅腿才能从两万六千多根白色细支柱的背景中凸显出来.台阶以及构成坐席的围栏和凸出的支架遍布整个网格结构,参观者被缠绕在纵横交错的线状阴影中.圆形的透明聚碳酸酯板可以遮风挡雨,亦可反射日光. | Shannon Werle 康康 | 2013 | 艺术界2013，，5： | 2 |
| 6 | Study of broadband emission of an ultraviolet preionized 20-atm CO2 laser显示文摘 | WAN C Y WERLING U RENK K F | 1985 | J Appl Phys1985，57，3： | 1 |
| 7 | Troposphere Mapping Functions for GPS and Very Long Baseline Interferometry from European Centre for Medium-Range Weather Forecasts Operational Analysis Data 显示文摘 | Boehm J Werl B Schuh H | 2006 | Journal of Geophysical Research2006，111，： | 1 |
| 8 | Signalprocessing and calibration procedures for in situ diode-laser absorption spectroscopy显示文摘 | Werle P W Mazzinghi P Amatoa F D | 2004 | Spectrochimica ActaPart A2004，，60： | 1 |
| 9 | Current trends in hospital mergers and acquisitions 显示文摘 | Brown TC Jr Werling KA Walker BC | 2012 | Healthc Financ Manage2012，66，11： | 1 |
| 10 | Pattern recognition receptors in companion and farm animals-the key to unlocking the door to animal disease显示文摘 | Werling D Coffey T J | 2007 | The Veterinary Journal2007，174，2： | 1 |
| 11 | Immunohistochemical distinction of invasive from noninvasive breast lesions: a comparative study of p63 versus calponin and smooth muscle myosin heavy chain显示文摘 | Werling RW Hwang H Yaziji H | 2003 | AmJ Surg Pathol2003，27，1： | 1 |
| 12 | T-cell clonality determination using polymerase chain reaction (PCR) amplication of the T-cell receptor gamma chain gene and capillary electrophoresis of fluorescently labeled PCR products显示文摘 | Sprouse JT Werling R Hanke D | 2000 | Am J Clin Pathol2000，113，： | 1 |
| 13 | Natural and synthetic polymers as inhibitors of drug efflux pumps显示文摘 | WERLE M | 2008 | Pharm Res2008，25，3： | 1 |
| 14 | Radiation hybrid mapping of all 10 characterized bovine Toll‐like receptors显示文摘 | Mc Guire K Jones M Werling D | 2006 | Animal genetics2006，37，1： | 1 |
| 15 | Chitosan-aprotinin coated liposomes for oral peptide delivery: Development, characterisation and in vivo evaluation显示文摘 | WERLE M TAKEUCHI H | 2009 | Inter J Pharm2009，370，12： | 1 |
| 16 | MCP- 1 induces activation of MAP-kinases ERK, JNK and p38 MAPK in human endothelial cells显示文摘 | WERLE M SCHMAL U HANNA K | 2002 | Cardiovasc Res2002，56，： | 1 |
| 17 | Immunohistochemical distinction of invasive from noninvasive breast lesions显示文摘 | Werling RW Hwang H Yaziji H | 2003 | Am J Surg Pathol2003，27，1： | 1 |
| 18 | Levels and molecular size distribution of serum laminin in adult type 1 diabetic patients with and without microangiopathy 显示文摘 | Werle E Diehl E Hassladher C | 1998 | Metabolism1998，47，： | 1 |
| 19 | TOLL-like receptors linking innate and adaptive immune response 显示文摘 | Werling D Jungi TW | 2003 | Vet Immunol Immuno-pathol2003，91，1： | 1 |
| 20 | MCP-1 induces activation of MAP-kinases ERK, JNK and p38 MAPK in human endothelial cells 显示文摘 | Werle M Schmal U Hanna K | 2002 | Cardiovasc Res2002，56，2： | 1 |
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