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| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | The Patatin-Containing Phospholipase A pPLAIIα Modulates Oxylipin Formation and Water Loss in Arabidopsis thaliana显示文摘patatin 相关的 phospholipase A (pPLA ) 水解膜 glycerolipids 将生产 monoacyl 混合物和免费的丰满的酸。Phospholipids 被 pPLAII 在 sn-1 和 sn-2 劈开包括那些包含的 oxophytodienoic 酸,位置,和 galactolipids 能也用作底层。pPLAII 的脱离减少了 lysophosphatidylcholine 和 lysophosphatidylethanolamine 层次,而是增加的免费的亚麻酸的酸。pPLAII 缺乏的植物显示了 jasmonic 酸和甲基的高水平 jasmonate,以及 oxylipin-biosynthetic 中介 13-hydroperoxylinolenic 酸和比酸的 12-oxophytodienoic 野类型(WT ) 植物。涉及 oxylipin 生产的基因的表示比在 WT 植物在 pPLAII 缺乏的异种也是更高的。变异的植物比 WT 植物更快速失去了水。WT 和变异的植物的 stomata 对 abscisic 酸同样作出回应。响应干燥,异种和 WT 叶子以一样的率生产了 abscisic 酸,,但是,在干燥的 4h 以后, jasmonic 酸水平比 WT 离开的在异种是高得多的。这些结果显示 pPLAII 否定地调整 oxylipin 生产并且从膜在氧化地修改的丰满的酸的移动建议一个角色。 | Wen-Yu Yang Yong Zheng Sung Chul Bahn Xiang-Qing Pan Mao-Yin Li Hieu Sy Vu Mary R.Roth Brad Scheu Ruth Welt Yue-Yun Hong Xue-Min Wang | 2012 | Molecular Plant2012，5，2： | 5 |
| 3 | CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes显示文摘AIM:To analyze the role of CYLD for receptor-mediated cell death of murine hepatocytes in acute liver injury models.METHODS:Hepatocyte cell death in CYLD knockout mice(CYLD-/-)was analyzed by application of liver injury models for CD95-(Jo2)and tumor necrosis factor(TNF)-α-[D-Gal N/lipopolysaccharide(LPS)]induced apoptosis.Liver injury was assessed by measurement of serum transaminases and histological analysis.Apoptosis induction was quantified by cleaved PARP staining and Western blotting of activated caspases.Nuclear factor(NF)-κB,ERK,Akt and jun amino-terminal kinases signaling were assessed.Primary Hepatocytes were isolated by two step-collagenase perfusion and treated with recombinant TNF-αand with the CD95-ligand Jo2.Cell viability was analyzed by MTT-assay.RESULTS:Livers of CYLD-/-mice showed increased anti-apoptotic NF-κB signaling.In both applied liver injury models CYLD-/-mice showed a significantly reduced apoptosis sensitivity.After D-Gal N/LPS treatment CYLD-/-mice exhibited significantly lower levels of alanine aminotransferase(ALT)(295 U/L vs 859 U/L,P<0.05)and aspartate aminotransferase(AST)(560 U/L vs 1025 U/L,P<0.01).After Jo injection CYLD-/-mice showed 2-fold lower ALT(50 U/L vs 110 U/L,P<0.01)and lower AST(250 U/L vs 435 U/L,P<0.01)serumlevels compared to WT mice.In addition,isolated CYLD-/-primary murine hepatocytes(PMH)were less sensitive towards death receptor-mediated apoptosis and showed increased levels of Bcl-2,XIAP,c IAP1/2,survivin and c-FLIP expression upon TNF-and CD95-receptor triggering,respectively.Inhibition of NF-κB activation by the inhibitor of NF-κB phosphorylation inhibitor BAY 11-7085 inhibited the expression of antiapoptotic proteins and re-sensitized CYLD-/-PMH towards TNF-and CD95-receptor mediated cell death.CONCLUSION:CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-κB dependent anti-apoptotic signaling. | Toni Urbanik Bruno Christian Koehler Laura Wolpert Christin Elbner Anna-Lena Scherr Thomas Longerich Nicole Kautz Stefan Welte Nadine Hovelmeyer Dirk Jager Ari Waisman Henning Schulze-Bergkamen | 2014 | World Journal of Gastroenterology2014，20，45： | 3 |
| 4 | A salt wasting syndrome associated with cerebral aisease显示文摘 | Peters JB Welt KG Sims EAH | 1950 | Tram Ass Am Physiol1950，，63： | 1 |
| 5 | Preparative hydrocarbon group type determination by automated medium pressure liquid chromatography 显示文摘 | Radke M Willsch H Welte D H | 1980 | Anal Chem1980，52，3： | 1 |
| 6 | Efficacy and tolerability of budesonide/formoterol added to tiotropium in patients with chron- ic obstructive pulmonary disease 显示文摘 | Welte T Miravitlles M Hernandez P | 2009 | Am J Respir Crit Care Med2009，180，： | 1 |
| 7 | Adenosinetriphosphate in rat renal papilla: effects of vasopressin and of ischemia 显示文摘 | Jones NF Welt LG | 1967 | Am J Phvsiol1967，212，4： | 1 |
| 8 | Leukocyte recruitment and expression of chemokines following different forms of vascular injury显示文摘 | Welt FG Tso C Edelman ER | 2003 | Vasc Med2003，8，1： | 1 |
| 9 | Mycoplasma pneumoniae pneumonia revisited within the German Competence Network for Community-acquired pneumonia显示文摘 | Baum H Welte T Marre R et aI | 2009 | BMC Infect Dis2009，9，5： | 1 |
| 10 | Goal-oriented treatment and combination therapy for pulmonary arterial hypertension 显示文摘 | Hoeper M M Markevych I Spiekerkoetter E Welte T Niedermeyer J | 2005 | Eur Respir J2005，26，： | 1 |
| 11 | A patient's guide: polycystic ovary syndrome(PCOS)显示文摘 | Hoeger K M Legro R S Welt C K | 2014 | J Clin Endocrinol Metab2014，99，1： | 1 |
| 12 | Inflammation and restenosis in the stent era 显示文摘 | Welt F G Rogers C | 2002 | Arterioscler Thromb Vasc Biol2002，22，11： | 1 |
| 13 | Rethinking the concepts of community-acquired and health-care-associated pneumonia 显示文摘 | Ewig S Welte T Chastre J | 2010 | Lancet Infect Dis2010，10，4： | 1 |
| 14 | A salt wasting syndrome associated with cerebral disease显示文摘 | Peters JP Welt LG Sims EA | 1950 | J Trans Assoc Am Physicians1950，63，6： | 1 |
| 15 | Theuseofnoninvasive positive pressure ventilation for severe respiratory insufficiency due to pulmonaryoedema显示文摘 | Hoffmannb Welte T | 1999 | Intensive Care Med1999，25，1： | 1 |
| 16 | Localization of TFF3, a new mucus-associated peptide of the human respiratory tract显示文摘 | Wiede A Jagla W Welte T | 1999 | Am J Respir Crit Car Med1999，159，4： | 1 |
| 17 | Patient derived cell culture and isolation of CD133+ putative cancer stem cells from melanoma显示文摘 | Welte Y Davies C Sch~fer R | 2013 | J Vis Exp2013，13，73： | 1 |
| 18 | DNA序列分析的若干新技术显示文摘DNA序列分析在基因工程和分子生物学研究中一直是一项重要的手段。近几年DNA序列分析有许多新的改进,特别是对于Sanger的酶法测序,因为该法一直被广泛采用。 我们知道,在酶法测序中,DNA聚合酶和DNA片段的标记是两大关键步骤。因此本文着重讨论与这两方面有关的新技术,并对若干测序用的重要新试剂也略加介绍。 | Marc Welt 沈孝宙 | 1992 | 生物工程进展1992，12，3： | 1 |
| 19 | Ertapenem : the new carbapenem 5 years after first FDA licensing for clinical practice 显示文摘 | Burkhardt O Derendorf H Welte T | 2007 | Expert Opin Pharmacother2007，8，2： | 1 |
| 20 | Accumulation of organic carbonrich sediments in the Late Jurassic and Cretaceous Atlantic Ocean- A synthesis 显示文摘 | Stein R RullkOtter J Welte D H | 1986 | Chem Geol1986，56，： | 1 |
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