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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer显示文摘 | Marko NF Suh JH Chao ST Barnett GH Vogelbaum MA Toms S Well R J Angelov L | 2011 | 中国神经肿瘤杂志2011，9，1： | 4 |
| 3 | A Review on Thermal Decomposition and Combustion of Thermoplastic Polyesters 显示文摘 | SEGEI V EDWAD L WElL D | 2004 | Polym Adv Teehnol2004，15，： | 1 |
| 4 | Analysis of rotor-rotor and stator-stator interferences in multistage turbomachines显示文摘 | He L Chen T Wells G | 2002 | ASME Journal of Turbomachinery2002，124，4： | 1 |
| 5 | O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits显示文摘 | Wells L Kreppel LK Comer FI | 2004 | J Biol Chem2004，279，38： | 1 |
| 6 | Bargaining power of multinationals andhost governments 显示文摘 | N fAGRE l T WEllS | 1982 | Journal of Management Studies1982，，3： | 1 |
| 7 | The neuropsychoolygical effects of obstructive sleep apnea: a meta-analysis of normreferenced and case-controlled data显示文摘 | Beebe D W Groesz L Wells C | 2003 | Sleep2003，26，3： | 1 |
| 8 | Prediction of bile duct stones and complications in biliary pancreatitis using early laboratory trends 显示文摘 | Cohen ME Slezak L Wells CK | 2001 | Am J Gastroenterol2001，96，12： | 1 |
| 9 | Glycosylation of nucleocytoplasmic proteins:signal transduction and O-GlcNAc显示文摘 | Wells L Vosseller K Hart GW | 2001 | Science2001，291，5512： | 1 |
| 10 | Transport of genistein-7-glucoside by human intestinal Caco-2 cells: poteintial role for MRP2 显示文摘 | Wells U K French K L Walgren R A | 1999 | Res Comm Mole Pathol Pharm1999，103，1： | 1 |
| 11 | Coloured petri nets and CPN tools for modelling and validation of concurrent systems显示文摘 | Jensen K Kristensen L M Wells L | 2007 | International Journal on Software Tools for Technology Transfer2007，9，34： | 1 |
| 12 | Shallow-water imaging multibeam sonar:a new tool for investigating seafloor processes in the coastal zone and on the continental shelf显示文摘 | CLARKE J E H MAYER L A WELLS D E | | 0，，06： | 1 |
| 13 | Genomic ap- proaches in the identification of hypoxia biomarkers in model fish species显示文摘 | ZhangZP Ju Z L Wells MC | 2009 | Journal of Experimental Marine Biology and Ecology2009，381，1： | 1 |
| 14 | The Spatial Characteristics of Stand Structure in Pinus Torreyana 显示文摘 | Wells M L Getis A | 1999 | Plant Ecology1999，143，： | 1 |
| 15 | Correlation of time temperature indicator response with microbial growth in pasteurized milk 显示文摘 | GRISIUS R WELLS J H BARRET E L | 1987 | Journal of Food Processing and Preservation1987，11，： | 1 |
| 16 | Continuous peripheral nerve blockade for inpatient and outpatient postoperative analgesia in children显示文摘 | Ganesh A Rose JB Wells L | 2007 | Anesth Analg2007，105，5： | 1 |
| 17 | Efficacy of continuous passive motion following total knee arthroplasty: A meta - analysis显示文摘 | Brosseau L Milne S Wells G | 2004 | J Rheumatol2004，31，11： | 1 |
| 18 | The complexation of ‘dissolved' Cu, Zn, Cd and Pb by soluble and colloidal organic maatter in Narragansett Bay, RI 显示文摘 | WELLS M L KOZELKA P B BRULAND K W | 1998 | Marine Chemistry1998，62，34： | 1 |
| 19 | Colored Petri nets and CPN tools for modeling and validation of concurrent systems 显示文摘 | JENSEN K KRISTENSEN L M WELLS L | 2007 | In- ternational Journal on Software Tools for Technology Transfer2007，9，3： | 1 |
| 20 | Detoxifying toxicants: interactions between sulfide and irontoxicity in freshwater wetlands 显示文摘 | Van Der Welle MEW Cuppens M Lamers L P M | 2006 | Environ Toxicol Chem2006，25，： | 1 |
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