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| 1 | Downregulation of electroacupuncture at ST36 on TNF-α in rats with ulcerative colitis显示文摘AIM: To investigate the regulatory effect of electroacupuncture (EA) at Zusanli (ST36) on tumor necrosis factor-alpha (TNFα) in rats with ulcerative colitis (UC), and further elucidate the therapeutic mechanism of EA on UC.METHODS: Thirty-two male Sprague-Dawley (SD) rats were randomly divided into four groups (n=-8): normal control group, UC control group, UC+ST36 group and UC+nonacupoint group. A solution containing ethanol and 2,4,6-trinitrobenzenesulfonic acid (TNBS) was instilled into the distal colon in the rat (at a dose of 100 mg/kg) to set up UC rat model. Rats in wakefulness state of UC+ST36 group were stimulated at ST36 by EA once a day, while those of UC+nonacupoint group were done at 0.5 cm beside ST36. After 10d treatment, all rats were sacrificed simultaneously. Colon musocal inflammation and damage were assessed by measuring colon mass, morphologic damage score, colonic myeloperoxidase enzyme (MPO) activity, serum TNF-α and colonic TNF-α mRNA level. Morphologic damage score was examined under stereomicroscope. Colonic MPO activity was measured by spectrophotometer method. Serum TNF-αconcentration was determined by radioimmunoassay (RIA).Colonic TNF-α mRNA expression level was analyzed by semiquantitative reverse transcription polymerase chain reaction (RT-PCR).RESULTS: Ratio of colonic mass/body mass (mC/mB) and activity of colonic MPO (μkat/g tissue) markedly increased (8.5±2.6 vs 2.5±0.4; 145±25 vs 24±8, P<0.01 vs normal control group). Compared with normal control rats, serum TNF-α and colonic TNF-α mRNA level in UC control group were increased 2.5 fold (2 278±170 vs 894±248, P<0.01)and 4.3 fold (0.98±0.11 vs 0.23±0.11, P<0.01)respectively. After EA at ST36, mc/mB and MPO activity were reduced significantly (5.3±2.0 vs 8.5±2.6; 104±36 vs145±25, P<0.01, 0.05) compared with those of UC control group. Serum TNF-α and colonic TNF-α mRNA level were inhibited by EA stimulation at ST36 (P<0.01). The inhibitory rate was 16 % and 44 % respectively.Morphologic damage score was also increased markedly in rat with UC (P<0.01), whereas it was decreased by EA at ST36 (P<0.05). There was no significant difference between UC control group and UC+EA at non-acupoint (P>0.05). Furthermore, these parameters were highly correlated with each other (P<0.01).CONCLUSION: Serum TNF-α concentration and colonic TNF-α mRNA expression level are increased significantly in UC rats in correlation with the severity of disease. It indicates that TNF-α is closely involved in the immune abnormalities and inflammatory responses in UC. EA at ST36 has therapeutic effect on UC by downregulating serum TNF-r and colonic TNF-r mRNA expression. High levels of TNF-αand its corresponding mRNA expression seem to be implicated in the pathogenesis of UC. | LiTian Yu-XinHuang MinTian WeiGao QingChang | 2003 | World Journal of Gastroenterology2003，9，5： | 25 |
| 2 | PERIODIC SOLUTIONS FOR NEUTRAL LINARD EQUATION WITH A STATEMENT-DEPENDENT DEVIATION VARIABLE显示文摘Using the theroy of topological degree, the paper studies the periodic solutions to a type of neutral Lienard equation with state-dependent deviation variable. A sufficient condition for the existence of periodic solution is obtained. | Liu Xiping Jia Mei Yang Liu Ge Weigao | 2005 | Annals of Differential Equations2005，21，3： | 6 |
| 3 | On the periodic solutions of a type of differential-iterative equations显示文摘Sufficient conditions for the existence of periodic solutions to a type of nonautonomous differential_iterative equations are given. | GE Weigao 1, LIU Zhengrong 2 and YU Yuanhong 3 1. Department of Applied Mathematics, Beijing Institute of Technology, Beijing 100081, China 2. Department of Mathematics, Yunnan University, Kunming 650091, China 3. Institute of Applied Mathematics, C | 1998 | Chinese Science Bulletin1998，43，3： | 4 |
| 4 | Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis显示文摘A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel.The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis.This treatment also inhibited the expression of the cell cycle regulatory proteins,survivin,cyclinD1,c-Myc and CDK4 and enhanced the sensitivity of U-87MG cells to paclitaxel. | Yunliang Xie Yanbo Liu Weigao Shen Bo Zhang Qun Liu | 2012 | Neural Regeneration Research2012，7，13： | 3 |
| 5 | TWO EXISTENCE THEOREMS OF PERIODIC SOLUTIONS FOR DIFFERENTIAL DELAY EQUATIONS显示文摘TWOEXISTENCETHEOREMSOFPERIODICSOLUTIONSFORDIFFERENTIALDELAYEQUATIONS￥GEWEIGAOAbstract:Thispapercorrectsandimprovestwotheorems... | GE WEIGAO(Department of APPlied Matehematics, Beijing Institiue of Thechnology, Beijign 100081, China) | 1994 | Chinese Annals of Mathematics,Series B1994，15，2： | 3 |
| 6 | Pipe-assembly approach for ships using modified NSGA-Ⅱ algorithm显示文摘Pipe-routing for ship is formulated as searching for the near-optimal pipe paths while meeting certain objectives in an environment scattered with obstacles. Due to the complex construction in layout space, the great number of pipelines, numerous and diverse design constraints and large amount of obstacles, finding the optimum route of ship pipes is a complicated and time-consuming process. A modified NSGA-Ⅱ algorithm based approach is proposed to find the near-optimal solution to solve the problem. By simplified equipment models, the layout space is firstly divided into three dimensional(3D) grids to build its mathematical model. In the modified NSGA-Ⅱ algorithm, the concept of auxiliary point is introduced to improve the search range of maze algorithm(MA) as well as to guarantee the diversity of chromosomes in initial population. Then the fix-length coding mechanism is proposed, Fuzzy set theory is also adopted to select the optimal solution in Pareto solutions. Finally, the effectiveness and efficiency of the proposed approach is demonstrated by the contrast test and simulation. The merit of the proposed algorithm lies in that it can provide more appropriate solutions for the designers while subject certain constrains. | Sui Haiteng Niu Wentie Niu Yaxiao Zhou Chongkai Gao Weigao | 2016 | Computer Aided Drafting,Design and Manufacturing2016，26，2： | 2 |
| 7 | Mapping a mammalian adult adrenal gland hierarchy across species by microwell-seq显示文摘Recently,single-cell RNA-seq technologies have been rapidly updated,leading to a revolution in biology.We previously developed Microwell-seq,a cost-effective and high-throughput single cell RNA sequencing(scRNA-seq)method with a very simple device.Most cDNA libraries are sequenced using an expensive Illumina platform.Here,we present the first report showing combined Microwell-seq and BGI MGISEQ2000,a less expensive sequencing platform,to profile the whole transcriptome of 11,883 individual mouse adult adrenal gland cells and identify 18 transcriptionally distinct clusters.Moreover,we performed a single-cell comparative analysis of human and mouse adult adrenal glands to reveal the conserved genetic networks in these mammalian systems.These results provide new insights into the sophisticated adrenal gland hierarchy and provide a benchmark,low-cost strategy for highthroughput single-cell RNA study. | Shujing Lai Lifeng Ma Weigao E Fang Ye Haide Chen Xiaoping Han Guoji Guo | 2020 | Cell Regeneration2020，9，1： | 2 |
| 8 | ON THE EXISTENCE OF SOLUTIONS TO A TYPE OF NONLINEAR DIFFERENTIAL-ITERATIVE EQUATIONS显示文摘Under the assumption that h(z) is strictly monotone the existence of solutions to a type of nonlinear differential-iterative equations in the form of x’(t) = g(x(t)) -h(x(x(t))) is discussed according to the behavior of the quasi-isoclinic curve C: x=h^-1 (g(t)) | GE WEIGAO(Department of Applied Mathematics, Beijing Institute of Technology, Beijing 100081, China.) LI CUIZHE(Department of Applied Mathematics, Beijing Institute of Technology, Beijing 100081, China.) YU YUANHONG(Inditute of Applied Mathematics, Acad | 2000 | Chinese Annals of Mathematics,Series B2000，21，2： | 2 |
| 9 | Upper and lower solution method for a four-point boundary value problem at resonance显示文摘 | Bai Zhanbing Li Wenglin Ge Weigao | 2005 | Nonlinear Analysis2005，，60： | 1 |
| 10 | Positive solutions for fractional four-point boundary value problems 显示文摘 | ZHAO Xiangkui CHAI Chengwen GE Weigao | 2011 | Commun Nonlinear Sci Numer Simulat2011，16，9： | 1 |
| 11 | New existence results for higher-order nonlinear fractional differential equa- tion with integral boundary conditions 显示文摘 | FENG Meiqiang ZHANG Xuemei GE Weigao | 2011 | Boundary Value Problems2011，2011，： | 1 |
| 12 | Existence of periodic solutions for a prescribed mean curvature Liénard p-Laplaceian equation with two delays显示文摘 | LI Zhiyan AN Tianqing GE Weigao | 2014 | Adv Differ Equ2014，2014，： | 1 |
| 13 | The existence of solutions of m-point boundary value problems at resonance显示文摘 | Ge Weigao | 2005 | Acta Math AppI Sin2005，28，： | 1 |
| 14 | Certain of second differential inequality of neutral type显示文摘 | WANG Peiguang GE Weigao | 2000 | Appl Math Letters2000，13，： | 1 |
| 15 | Periodic solutions to a second order nonlinear neutral functional differential equation in the critical case显示文摘 | Lu Shiping Gui Zhanji Ge Weigao | 2006 | Nonlinear Analysis2006，64，： | 1 |
| 16 | Predictably synthesizing a library of white-light-emitting perovskites显示文摘The low-dimensional organic-inorganic halide perovskites with self-trapped exciton emission have promising prospects for single-phase white-light emitters. However, so far, these broadband white-light-emitting(BWLE) perovskites were synthesized by trial-and-error testing spacing molecules. Here, we developed a steric hindrance regulation strategy to predictably synthesize BWLE perovskites. The molecules containing C–C(–NH_(2))–C groups were introduced into low-dimensional perovskites, which brings a large steric hindrance in-plane orientation. The bigger C–C(–NH_(2))–C bond angle would induce larger structural distortion in perovskites, which leads to the higher rate of self-trapping of excitons and the deeper self-trapping depth. The photoluminescence spectra of the synthesized perovskites can cover the cool-to-warm white light region. Overall, we fabricated a material library consisting of 40 kinds of BWLE compounds according to this strategy. Our findings develop a general strategy to synthesize BWLE perovskites and offer a material platform for optoelectronic applications. | Ludan Niu Lili Zhao Deyu Li Qian Chen Mingming Zhang Jing Luan Lei Wang Weigao Xu Jun Xing | 2023 | Science China Chemistry2023，66，3： | 1 |
| 17 | Sufficient conditions for the existence of periodic solutions to some second order differential equations with a deviating argument显示文摘 | LU Shiping GE Weigao | 2005 | Math Anal2005，308，2： | 1 |
| 18 | Some fixed point theorems and existence of positive solutions of two-point boundary-value problems显示文摘 | GE Weigao XUE Chunyan | 2009 | Nonlinear Analysis2009，70，1： | 1 |
| 19 | Periodic solutions of neutral differential equation with multiple deviating arguments显示文摘 | Lu Shiping Ge Weigao | 2004 | Applied Mathematics and Computation2004，156，： | 1 |
| 20 | Interface engineering in two-dimensional heterostructures towards novel emitters显示文摘Two-dimensional(2D) semiconductors have captured broad interest as light emitters, due to their unique excitonic effects. These layer-blocks can be integrated through van der Waals assembly, i.e., fabricating homo-or heterojunctions, which show novel emission properties caused by interface engineering. In this review, we will first give an overview of the basic strategies that have been employed in interface engineering, including changing components, adjusting interlayer gap, and tuning twist angle. By modifying the interfacial factors, novel emission properties of emerging excitons are unveiled and discussed. Generally, well-tailored interfacial energy transfer and charge transfer within a 2D heterostructure cause static modulation of the brightness of intralayer excitons. As a special case, dynamically correlated dual-color emission in weakly-coupled bilayers will be introduced, which originates from intermittent interlayer charge transfer. For homobilayers and type Ⅱ heterobilayers, interlayer excitons with electrons and holes residing in neighboring layers are another important topic in this review. Moreover, the overlap of two crystal lattices forms moiré patterns with a relatively large period, taking effect on intralayer and interlayer excitons. Particularly, theoretical and experimental progresses on spatially modulated moiré excitons with ultra-sharp linewidth and quantum emission properties will be highlighted. Moiré quantum emitter provides uniform and integratable arrays of single photon emitters that are previously inaccessible, which is essential in quantum many-body simulation and quantum information processing. Benefiting from the optically addressable spin and valley indices, 2D heterostructures have become an indispensable platform for investigating exciton physics, designing and integrating novel concept emitters. | Hua Li Jinyang Ling Jiamin Lin Xin Lu Weigao Xu | 2023 | Journal of Semiconductors2023，44，1： | 1 |
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