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| 1 | 针刀联合痛点阻滞改善冈上肌腱炎肩关节痛和肩关节活动度的临床研究显示文摘目的观察针刀联合痛点阻滞疗法改善冈上肌腱炎肩关节痛和肩关节活动度的临床疗效。方法自2015年1月~2016年9月招募航天中心医院门诊及病房的冈上肌腱炎患者105例,采用随机数字表将其随机分为针刀组、痛点阻滞组和针刀联合痛点阻滞组,每组35例。取穴:冈上肌腱止点。针刀组于冈上肌腱止点针刀松解,痛点阻滞组于冈上肌腱止点注射消炎镇痛液,针刀联合痛点阻滞组于冈上肌腱止点注射消炎镇痛液后,再行针刀松解。三组患者每周治疗1次,共计3次,3周后随访。采用视觉模拟评分(VAS)评价疼痛度、肩关节功能CMS评分(C-M)评价肩关节活动度。结果针刀联合痛点阻滞组综合疗效最好(P<0.05)。三组治疗后第1、2、3周的VAS、C-M评分均较治疗前显著降低(P<0.01)。第3周时,针刀联合痛点阻滞组与其他两组比较,VAS评分降低最显著(P<0.01),且降低VAS评分的趋势最明显(P<0.05)。第2周和第3周时,针刀联合痛点阻滞组与其他两组比较,C-M评分升高均最显著(P<0.01、P<0.05),且提高C-M评分的趋势最明显(P<0.05)。结论针刀联合痛点阻滞缓解肩关节痛的疗效最好,且能更早地提高肩关节活动度。 | 张昶 王瑞红 徐耀 袁宝石 王婧 廖奕歆 Thomas Wardell | 2017 | 中国医药导报2017，14，9： | 8 |
| 2 | Classification of Short Time Series in Early Parkinson’s Disease With Deep Learning of Fuzzy Recurrence Plots显示文摘There are many techniques using sensors and wearable devices for detecting and monitoring patients with Parkinson’s disease(PD).A recent development is the utilization of human interaction with computer keyboards for analyzing and identifying motor signs in the early stages of the disease.Current designs for classification of time series of computer-key hold durations recorded from healthy control and PD subjects require the time series of length to be considerably long.With an attempt to avoid discomfort to participants in performing long physical tasks for data recording,this paper introduces the use of fuzzy recurrence plots of very short time series as input data for the machine training and classification with long short-term memory(LSTM)neural networks.Being an original approach that is able to both significantly increase the feature dimensions and provides the property of deterministic dynamical systems of very short time series for information processing carried out by an LSTM layer architecture,fuzzy recurrence plots provide promising results and outperform the direct input of the time series for the classification of healthy control and early PD subjects. | Tuan D.Pham Karin Wardell Anders Eklund Goran Salerud | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，6： | 8 |
| 3 | The IBI1 Receptor ofβ-Aminobutyric Acid Interacts with VOZ Transcription Factors to Regulate Abscisic Acid Signaling and Callose-Associated Defense显示文摘Extemal and internal signals can prime the plant immune system for a faster and/or stronger response to pathogen attack.β-aminobutyric acid(BABA)is an endogenous stress metabolite that induces broad-spectrum disease resistance in plants.BABA perception in Arabidopsis is mediated by the aspartyl tRNA synthetase IBI1,which activates priming of multiple immune responses,including callose-associated cell wall defenses that are under control by abscisic acid(ABA).However,the immediate signaling components after BABA perception by IBI1,as well as the regulatory role of ABA therein,remain unknown.Here,we have studied the early signaling events controlling IBI1-dependent BABA-induced resistance(BABAIR),using untargeted transcriptome and protein interaction analyses.Transcriptome analysis revealed that IBI1-dependent expression of BABA-IR against the biotrophic oomycete Hyaloperonospora arabidopsidis is associated with suppression of ABA-inducible abiotic stress genes.Protein interaction studies identified the VOZ1 and VOZ2 transcription factors(TFs)as IBI1-interacting partners,which are transcrip-tionally induced by ABA but suppress pathogen-induced expression of ABA-dependent genes.Furthermore,we show that VOZ TFs require nuclear localization for their contribution to BABA-IR by mediating augmented expression of callose-associated defense.Collectively,our study indicates that the IBI1-VOZ signaling module channels pathogen-induced ABA signaling toward cell wall defense while simultaneously suppressing abiotic stress-responsive genes. | Roland E.Schwarzenbacher Grace Wardell Joost Stassen Emily Guest Peijun Zhang Estrella Luna Jurriaan Ton | 2020 | Molecular Plant2020，13，10： | 4 |
| 4 | The barren stalk2 Gene Is Required for Axillary Meristem Development in Maize显示文摘The diversity of plant architecture is determined by axillary meristems (AMs). AMs are produced from small groups of stem cells in the axils of leaf primordia and generate vegetative branches and reproductive inflorescences . Previous studies identified genes critical for AM development that function in auxin biosynthesis, transport, and signaling. barren stalkl (ba1), a basic helix-loop-helix transcription factor, acts downstream of auxin to control AM formation. Here, we report the cloning and characterization of barren stalk2 (ba2), a mutant that fails to produce ears and has fewer branches and spikelets in the tassel, indicating that ba2 functions in reproductive AM development. Furthermore, the ba2 mutation suppresses tiller growth in the teosinte branchedl mutant, indicating that ba2 also plays an essential role in vegetative AM development. The ba2 gene encodes a protein that co-localizes and heterodimerizes with BA1 in the nucleus . Characterization of the genetic interaction between ba2 and ba1 demonstrates that ba1 shows a gene dosage effect in ba2 mutants, providing further evidence that BA1 and BA2 act together in the same pathway. Characterization of the molecular and genetic interaction between ba2 and additional genes required for the regulation of ba1 further supports this finding. The ba1 and ba2 genes are orthologs of rice genes, LAX PANICLE1 (LAX1) and LAX2, respectively, hence providing insights into pathways controlling AMs development in grasses. | Hong Yao Andrea Skirpan Brian Wardell Michaela S.Matthes Norman B.Best Tyler McCubbin Amanda Durbak Taylor Smith Simon Malcomber Paula McSteen | 2019 | Molecular Plant2019，12，3： | 4 |
| 5 | Effect of first myocardial infarction on left ventrieular systolic and diastolic function with the use of mitral annular velocity determined by pulse wave Doppler tissue imaging显示文摘 | Alam M Wardell J Andersson E | 2000 | J Am Soc Echocardiography2000，13，5： | 1 |
| 6 | Effects of first myocardial infarction on left ventricular systolic and diastolic function with the use of mitral annular velocity determined by pulsed wave Doppler tissue imaging显示文摘 | Alam M Wardell J Andersson E | 2000 | J Am Soc Echocardiogr2000，13，5： | 1 |
| 7 | An Intermodal Optimum Path Algorithm for Multimodal Networks with Dynamic Arc Travel Times and Switching Delays显示文摘 | Ziliaskopoulos A Wardell W | 2000 | European Journal of Operational Research2000，，125： | 1 |
| 8 | Run length distributions of special cause control charts for correlated process(with discussion)显示文摘 | Wardell D G Moskowitz H Plante R D | 1994 | Technometrics1994，36，： | 1 |
| 9 | Cancer whole-genome sequencing: present and future 显示文摘 | Nakagawa H Wardell CP Furuta M | 2015 | Oncogene2015，90，： | 1 |
| 10 | Effects of first myocardial infarcion on left ventricular systolic and diastolic function with the use of mitral annular velocity determined by pulsed wave Doppler tissue imaging显示文摘 | Alam M Wardell J Andersson E | 2000 | J Am Soc echocardiogr2000，13，5： | 1 |
| 11 | Right ventricular function inpatients with first inferior myocardial infarction:assessment by tricuspid annular motion and tricuspid annular velocity显示文摘 | ALAM M WARDELL J ANDERSSON E | 2000 | Am Heart J2000，139，： | 1 |
| 12 | Extraction of gallium and germanium from domestic resources 显示文摘 | JUDD J C WARDELL M P DAVIDSON C F | 1988 | Light Metals1988，，： | 1 |
| 13 | Spatial heterogeneity in normal skin perfusion recorded with laser Doppler imaging and flowmetry显示文摘 | Wardell K Braverman IM Silverman DG | 1994 | Microcir Res1994，48，： | 1 |
| 14 | Characteristics of mitral and tricuspid annular velocities determined by pulsed wave Doppler tissue imaging in healthy subject 显示文摘 | Alam M Wardell J Andersson E | 1999 | J Am Soc Echocardiogr1999，12，8： | 1 |
| 15 | Mitochondrial diabetes:investigation and identification of a novel mutation显示文摘 | Lynn S Wardell T Margaret A | 1998 | Diabetes1998，47，： | 1 |
| 16 | Effects of first myocardial infarction on left ventricular systolic and diastolic function with the use of mitral annular velocity determined by pulsed wave Doppler tissueimaging显示文摘 | ALAM M WARDELL J ANDERSSON E | 2000 | J Am Soc Echocardiography2000，13，： | 1 |
| 17 | MYC translocations in multiple myeloma involve recruitment of enhancer elements resulting in over-expression and decreased overall survival 显示文摘 | Walker BA Wardell CP Begum D | 2013 | Blood (ASH Annual Meeting Abstracts)2013，122，： | 1 |
| 18 | Effects of first myocardial infarction on left ventricular systolic and diastolic function with the use of mitral annular velocity determined by pulsed wave doppler tissue imaging显示文摘 | ALAM M WARDELL J ANDERSSON E | 2000 | J Am Soc Echocardiogr2000，13，5： | 1 |
| 19 | The decomposition kinetics of2(M=Ni,Pd)in a nitrogen atmosphere using thermogravimetry显示文摘 | Bemardo da Cruz A G Wardell J L Roeco A M | 2006 | Thermochimica Acta2006，443，2： | 1 |
| 20 | The potential con- sequences of pollinator declines on the conservation of hlodiversity and stability of food crop yields显示文摘 | Allen - Wardell G Bernhardt T Bitner R | 1998 | Conservation Biology1998，12，1： | 1 |
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