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| 1 | Estrogen enhances the functions of CD4^(+)CD25^(+)Foxp3^(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro显示文摘Cross-talk has been shown to occur between the immune system and bone metabolism pathways.In the present study,we investigated the impact of CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells on osteoclastogenesis and bone resorption.Treg cells that were isolated and purified from peripheral blood mononuclear cells(PBMCs)of healthy adults inhibited both the differentiation of osteoclasts(OCs)from human embryo bone marrow cells(BMCs)and the pit formation in a dose-dependent manner.In cell cocultures,the production levels of both interleukin-10(IL-10)and transforming growth factor-beta 1(TGF-β1)were proportionally upregulated as the ratio of Treg cells to BMCs was increased,and the inhibition of OC differentiation and bone resorption by Treg cells was completely reversed by anti-IL-10 and anti-TGF-β1 antibodies.Treatment of BMC and Treg cell cocultures with 17β-estradiol(E2)at concentrations between 10^(-7) and 10^(-9) mol/l suppressed OC differentiation and bone resorption more efficiently than it did in cultures of BMCs alone;this enhanced suppression occurred via the stimulation of Treg cell IL-10 and TGF-b1 expression.These data suggest that Treg cells suppress OC differentiation and bone resorption by secreting IL-10 and TGF-β1.E2 enhances the suppressive effects of Treg cells on OC differentiation and bone resorption by stimulating IL-10 and TGF-β1 secretion from these cells.Therefore,Treg cell-derived IL-10 and TGF-b1 are likely involved in the regulation of E2 on bone metabolism and represent potential therapeutic targets for the treatment of postmenopausal osteoporosis(PMO). | CY Luo L Wang C Sun DJ Li | 2011 | Cellular & Molecular Immunology2011，8，1： | 33 |
| 2 | 杏仁核-海马环路参与抑郁症的发病机制显示文摘慢性应激常可引发抑郁症。临床资料显示,抑郁症病人的腹侧海马CA1区(vCA1)n体积减小。vCA1是否参与抑郁症的发病?vCA1通过什么环路起作用?其分子机制如何?是本文要回答的科学问题。研究者利用慢性不可预见性温和应激(CUMS),构建小鼠抑郁症模型。主要结果如下:(1)与对照组相比,CUMS组vCA1中表达c-Fos的兴奋性神经元的比例降低。采用化学遗传学方法激活vCA1内兴奋性神经元,可明显缓解抑郁样行为。因此,海马vCA1内兴奋性神经元的活性降低,介导抑郁症的发生。 | 刘风雨(译) Ma H Li CY Wang JP | 2021 | 中国疼痛医学杂志2021，27，2： | 9 |
| 3 | 慢性药物性肝损伤生化学未缓解的列线图预测模型的建立显示文摘【据Hepatology 2021年12月报道】题:慢性药物性肝损伤生化学未缓解的列线图预测模型的建立(作者Wang CY等)药物性肝损伤(DILI)已被公认为急性和慢性肝病的重要原因。虽然大多数经历DILI的患者在停用可疑药物后可获得临床和生化学的完全缓解,但仍有8%~20%的患者可进展为慢性DILI。反复出现生化学未缓解(BNR)的DILI患者可能进展至肝硬化甚至肝衰竭,生活质量差。目前慢性DILI的诊断仍然具有很大的挑战性,肝活检虽然有助于DILI诊断的正确性,但其临床应用受到了有创性及高成本的限制。此外,DILI的组织学及生化特征与预后的关系尚不明确。 | 纪冬 WANG CY DENG Y LI P | 2022 | 临床肝胆病杂志2022，38，1： | 8 |
| 4 | On abiogenic natural gas显示文摘NATURAL gases usually refer to the inflammable gases dominated by methane from the angle of research on energy gases. Three genetic types of natural gases can be recognized according to the process of methane generation: (ⅰ) biogenic (bacterial) gas, mainly the gas formed by the decomposition of organic matter in sediments under the action of anaerobic bacteria; (ⅱ) thermogenic gas, mainly the gas formed by the degradation of organic matter in sediments under the action of certain temperature and pressure; (ⅲ) abiogenic gas, mainly the | Wang, XB Li, CY Chen, JF Xia, XY Guo, ZQ Xie, HS | 1997 | Chinese Science Bulletin1997，42，16： | 5 |
| 5 | TRH microinjection into DVC enhances motility of rabbits gallbladder via vagus nerve显示文摘TRHmicroinjectionintoDVCenhancesmotilityofrabbitsgalbladderviavagusnerveLIUChuanYong,LIUJingZhang,ZHOUJianHua,WANGHanRu,... | Liu, CY Liu, JZ Zhou, JH Wang, HR Li, ZY Li, AJ Liu, KJ | 1998 | World Journal of Gastroenterology1998，4，2： | 4 |
| 6 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 7 | Single oxygen is the major species participating in the induction of DNA strand breakage and 8-hydroxydeoxyguanosine adduct by lead acetate显示文摘 | Yang JL Wang LC Chang CY | 1999 | Environmental and molecular mutagenesis1999，33，： | 2 |
| 8 | Asymmetric membrane capsules for delivery of poorly water-soluble drugs by osmotic effects 显示文摘 | Wang CY Ho HO Lin LH | 2005 | IntJPharm2005，297，12： | 1 |
| 9 | Comparison of two types of alginate microcapsules on stability and biocompatibility in vitro and in vivo显示文摘 | Li HB Jiang H Wang CY | 2006 | Biomed Mater2006，，1： | 1 |
| 10 | Prophylactic vertebroplasty may reduce the risk of adjacent intact vertebra from fatigue injury:an ex vivo biomechanical study显示文摘 | Chiang CK Wang YH Yang CY | 2009 | Spine (Phila Pa 1976)2009，34，： | 1 |
| 11 | Time to positivity of blood cultures of different Candida species causing fungaemia显示文摘 | Lai CC Wang CY Liu WL | 2012 | J Med Microbio12012，61，5： | 1 |
| 12 | NF-κB antiapoptosis: induction of TRAF1, TRAF2, c-IAP1 and c-IAP2 to suppress caspase-8 activation显示文摘 | Wang CY Mayo MW Korneluk RG | 1998 | Science1998，281，： | 1 |
| 13 | Experimental study of cardiac muscle tissue engineering in bioreactor显示文摘 | Liu X Wang CY Guo XM | 2003 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao2003，25，1： | 1 |
| 14 | Determination of dioxopromethazine hydrochloride by capillary electrophoresis with electrochemiluminescence detection显示文摘 | Li YH Wang CY Sun JY | 2005 | Analytica Chimica Acta2005，550，12： | 1 |
| 15 | Cytokine regulation of IL 12 receptor β2 expression: differential effects on human T and NK cells显示文摘 | Wu CY Gadina M Wang K | 2000 | Eur J Immunol2000，30，5： | 1 |
| 16 | Singlet oxygen is the major species participating in the induction of DNA strand breakage and 8-hydroxydeoxyguanosine adduct by lead acetate 显示文摘 | YANG JL WANG LC CHANG CY | 1999 | Environ Mol Mutagen1999，33，3： | 1 |
| 17 | High frequency of linezolid-associated thrombocytopenia and anemia among patients with end- stage renal disease显示文摘 | Wu VC Wang YT Wang CY | 2006 | Clin Infect Dis2006，42，1： | 1 |
| 18 | Population alterations of L-arginase-and inducible nitric oxide synthase-expressed CD11b^+/CD14^+/CD15^+/CD33^+ myeloid-derived suppressor cells and CD8^+ T lymphocytes in patients with advanced- stage non-small cell lung cancer 显示文摘 | Liu CY Wang YM Wang CL | 2010 | J Cancer Res Clin Oncol2010，136，1： | 1 |
| 19 | Cesarean scar defect: correlation between Cesarean section number, defect size, clinical symptoms and uterine position 显示文摘 | Wang CB Chiu WW Lee CY | 2009 | Ultrasound Obstet Gyneeol2009，34，： | 1 |
| 20 | Matrix MMP-- 9 gene polymor- phisms in nasal Doly显示文摘 | Wang LF Chien CY Tai CF | 2010 | BMC Med Genet2010，11，9： | 1 |
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