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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | Quality of life of patients with diabetes mellitus: An overview of research in primary health care in the Nordic countries 显示文摘 | Wandell PE | 2005 | Scand J Prim Health Care2005，23，2： | 1 |
| 3 | The role of tissue expansion in the treatment of atypical facial clefting显示文摘 | Toth BA Glafkides MC Wandel A | 1990 | Plast Reconstr Surg1990，86，1： | 1 |
| 4 | Effects of glucosamine,chon-droitin,or placebo in patients with osteoarthritis of hip or knee:net-work meta-analysis显示文摘 | Wandel S Jiini P Tendal B | 2010 | BMJ2010，，： | 1 |
| 5 | environmental concern in consumer evaluation food quality 显示文摘 | Margareta Wandel&Annechen Bugge | 1997 | Food Quality and Preference1997，8，： | 1 |
| 6 | Stray dog population demographics in Jodhpur, India following a population control/ra- bies vaccination program显示文摘 | Totton SC Wandeler AI Zinsstag J | 2010 | Prey Vet Med2010，97，1： | 1 |
| 7 | The drug transporter P-glycoprotein limits oral absorption andbrain entry of HIV- 1 protease inhibitors显示文摘 | Kim RB Fromm MF Wandel C | 1998 | J Clin Invest1998，101，2： | 1 |
| 8 | Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein显示文摘 | Kim RB Wandel C Leake B | 1999 | Pharm Res1999，16，： | 1 |
| 9 | Vulnerability to Climate Change in the Arctic:A Case Study from Arctic Bay Canada显示文摘 | James D Ford Barry Smit Johanna Wandel | 2006 | Global Environment Change2006，16，： | 1 |
| 10 | Diffusion properties of major white matter tracts in young, typically develo- ping children显示文摘 | Johnson R T Yeatman J D Wandell B A | 2014 | Neurolmage2014，88，： | 1 |
| 11 | Effects of glucosamine,chondroitin,or placebo in patients with osteoarthritis of hip or knee :network meta-analysis 显示文摘 | Wandel S J ii ni P Tendal B | 2010 | BMJ2010，341，： | 1 |
| 12 | Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network recta-analysis显示文摘 | Wandel S Juni P Tendal B | 2010 | BMJ2010，341，： | 1 |
| 13 | Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer显示文摘 | Church TR Wandell M Lofton-Day C | 2014 | Gut2014，63，2： | 1 |
| 14 | et al P-glycoprotein and cytochrome P-450 3A inhibition:dissociation of inhibitory potencies 显示文摘 | Wandel C Kim RB Kajiji S | 1999 | Cancer Res1999，59，： | 1 |
| 15 | Color Image Fidelity Metrics Evaluated Using Image Distortion Maps显示文摘 | ZHANG X M WANDELL B A | 1998 | Signal Processing1998，70，3： | 1 |
| 16 | Biolimus-eluting stent with biode- gredable polymer versus sirohmus-eluting stent with durable polymer for coro- nary revascularisation(LEADERS) :a randomized non-inferiority trial显示文摘 | Windecker S Serruys PW Wandel S | 2008 | Lan- cet2008，372，： | 1 |
| 17 | Third Party Logistics:Present and Future Prosperities显示文摘 | Sheffi and Wandel | 1990 | Journal of Business Logistics1990，9，： | 1 |
| 18 | Interrelationship between substrates and inhibitor of human CYP3A and P - glycoprotein显示文摘 | Kim RB Wandel C Leake B | 1999 | Pharm Res1999，16，： | 1 |
| 19 | Outcomes associated with drug-eluting and bare-metal stents : a collaborative network metaanalysis 显示文摘 | Stettler C Wandel S Allemann S | 2007 | Lancet2007，370，： | 1 |
| 20 | Acanthocyturiaacharacteristic marker for glomerular bleeding显示文摘 | Kohler H Wandel E Brunck B | 1991 | Kindey Int1991，40，： | 1 |
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